SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iwh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 8 ALA A 224
GLY A 245
THR A 240
ILE A 126
 None
 0.72A 1gtnI-4iwhA:
undetectable
1gtnJ-4iwhA:
undetectable		 1gtnI-4iwhA:
12.67
1gtnJ-4iwhA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 VAL A  68
ASP A   9
LEU A  93
PRO A  48
GLY A  41
 None
 1.48A 1ia0B-4iwhA:
2.3		 1ia0B-4iwhA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 VAL A  68
ASP A   9
LEU A  93
PRO A  48
GLY A  41
 None
 1.48A 1tubB-4iwhA:
2.9		 1tubB-4iwhA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 11 ILE A 103
THR A 256
LEU A 262
VAL A 321
GLN A 107
 None
 1.48A 1tw4A-4iwhA:
undetectable		 1tw4A-4iwhA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 PRO A  13
VAL A  16
ASN A  17
VAL A   5
 None
 0.71A 1z2bC-4iwhA:
undetectable		 1z2bC-4iwhA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 8 GLY A 343
THR A 344
ALA A 345
ALA A 346
 None
 0.38A 2ej3A-4iwhA:
undetectable		 2ej3A-4iwhA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 325
GLN A 327
VAL A 351
MET A 261
THR A 331
 None
 1.33A 2q7kA-4iwhA:
undetectable		 2q7kA-4iwhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 328
GLN A 327
MET A 347
VAL A 351
MET A 261
 None
 1.11A 2q7lA-4iwhA:
undetectable		 2q7lA-4iwhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 328
GLN A 327
VAL A 351
MET A 261
THR A 331
 None
 1.38A 2q7lA-4iwhA:
undetectable		 2q7lA-4iwhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 8 LEU A  49
LEU A  93
LEU A   6
ARG A  90
 None
 0.94A 2xn3A-4iwhA:
undetectable
2xn3B-4iwhA:
undetectable		 2xn3A-4iwhA:
22.25
2xn3B-4iwhA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 245
LEU A 248
ARG A 100
ILE A 238
ALA A 252
 None
 0.97A 3gwvA-4iwhA:
undetectable		 3gwvA-4iwhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		6 / 12 ALA A   4
ALA A  57
ALA A  60
VAL A  68
ILE A  86
LEU A  49
 None
 1.48A 3h0aA-4iwhA:
undetectable		 3h0aA-4iwhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 8 TYR A 275
ALA A  57
ALA A  60
LEU A 308
 None
 0.98A 3l4dA-4iwhA:
undetectable		 3l4dA-4iwhA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ALA A  67
PRO A  82
GLY A  38
GLY A  39
PRO A 277
 None
 0.95A 3m6wA-4iwhA:
undetectable		 3m6wA-4iwhA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ALA A  40
GLY A  12
PRO A  13
GLY A  10
LEU A 274
 None
 1.02A 4n49A-4iwhA:
undetectable		 4n49A-4iwhA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 9 LEU A 294
LEU A  23
SER A 299
LEU A 298
ILE A 317
 None
 1.26A 4ubsA-4iwhA:
undetectable		 4ubsA-4iwhA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 6 GLU A  83
GLY A  38
GLY A  39
ASP A   9
 None
 1.03A 5a06D-4iwhA:
undetectable		 5a06D-4iwhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 7 GLY A  10
GLY A  12
ASP A 284
ASP A   9
 None
 0.76A 5ergB-4iwhA:
undetectable		 5ergB-4iwhA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5H_A_ACTA1229_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 4 VAL A  16
GLU A  14
THR A 344
GLU A  18
 None
 1.25A 5g5hA-4iwhA:
0.0		 5g5hA-4iwhA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ARG A  90
ASN A  98
ASP A 250
 None
None
MG  A 401 (-2.7A)
 0.81A 5gwxA-4iwhA:
undetectable		 5gwxA-4iwhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 259
GLY A 260
ASP A 333
LEU A 122
ALA A 102
 None
 1.05A 5h5fA-4iwhA:
2.1		 5h5fA-4iwhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 TYR A 135
ILE A 134
LEU A 248
GLY A 245
 None
 0.87A 5kmdC-4iwhA:
undetectable
5kmdD-4iwhA:
undetectable		 5kmdC-4iwhA:
19.33
5kmdD-4iwhA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 7 GLY A  12
ALA A  40
ASP A  70
ASN A  17
 None
 0.92A 5mvsA-4iwhA:
undetectable		 5mvsA-4iwhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 8 GLY A  12
ALA A  40
ASP A  70
ASN A  17
 None
 0.93A 5mvsB-4iwhA:
undetectable		 5mvsB-4iwhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 10 ALA A  55
LEU A  54
LEU A  93
GLU A  59
ILE A  63
 None
 0.77A 5v02B-4iwhA:
undetectable
5v02R-4iwhA:
undetectable		 5v02B-4iwhA:
11.78
5v02R-4iwhA:
18.93