SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  45
PHE A  66
ILE A  11
LEU A 240
ASP A 241
 None
 1.15A 3ko0A-4iwmA:
undetectable
3ko0B-4iwmA:
undetectable
3ko0C-4iwmA:
1.2
3ko0D-4iwmA:
undetectable		 3ko0A-4iwmA:
17.05
3ko0B-4iwmA:
17.05
3ko0C-4iwmA:
17.05
3ko0D-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  45
PHE A  66
ILE A  11
LEU A 240
ASP A 241
 None
 1.14A 3ko0G-4iwmA:
undetectable
3ko0H-4iwmA:
undetectable
3ko0I-4iwmA:
undetectable
3ko0J-4iwmA:
1.2		 3ko0G-4iwmA:
17.05
3ko0H-4iwmA:
17.05
3ko0I-4iwmA:
17.05
3ko0J-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 240
ASP A 241
LEU A  45
PHE A  66
ILE A  11
 None
 1.15A 3ko0A-4iwmA:
undetectable
3ko0B-4iwmA:
undetectable
3ko0I-4iwmA:
undetectable
3ko0J-4iwmA:
1.2		 3ko0A-4iwmA:
17.05
3ko0B-4iwmA:
17.05
3ko0I-4iwmA:
17.05
3ko0J-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  45
PHE A  66
ILE A  11
LEU A 240
ASP A 241
 None
 1.11A 3ko0K-4iwmA:
undetectable
3ko0L-4iwmA:
undetectable
3ko0S-4iwmA:
1.2
3ko0T-4iwmA:
undetectable		 3ko0K-4iwmA:
17.05
3ko0L-4iwmA:
17.05
3ko0S-4iwmA:
17.05
3ko0T-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 240
ASP A 241
LEU A  45
PHE A  66
ILE A  11
 None
 1.13A 3ko0K-4iwmA:
undetectable
3ko0L-4iwmA:
undetectable
3ko0M-4iwmA:
undetectable
3ko0N-4iwmA:
undetectable		 3ko0K-4iwmA:
17.05
3ko0L-4iwmA:
17.05
3ko0M-4iwmA:
17.05
3ko0N-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  45
PHE A  66
ILE A  11
LEU A 240
ASP A 241
 None
 1.16A 3ko0M-4iwmA:
undetectable
3ko0N-4iwmA:
undetectable
3ko0O-4iwmA:
undetectable
3ko0P-4iwmA:
undetectable		 3ko0M-4iwmA:
17.05
3ko0N-4iwmA:
17.05
3ko0O-4iwmA:
17.05
3ko0P-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 240
ASP A 241
LEU A  45
PHE A  66
ILE A  11
 None
 1.12A 3ko0M-4iwmA:
undetectable
3ko0N-4iwmA:
undetectable
3ko0O-4iwmA:
undetectable
3ko0P-4iwmA:
undetectable		 3ko0M-4iwmA:
17.05
3ko0N-4iwmA:
17.05
3ko0O-4iwmA:
17.05
3ko0P-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A  70
HIS A 103
HIS A  71
 None
 0.66A 3mihA-4iwmA:
undetectable		 3mihA-4iwmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A  71
HIS A  70
HIS A 103
 None
 0.63A 3mihA-4iwmA:
undetectable		 3mihA-4iwmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A 103
HIS A  71
HIS A  70
 None
 0.58A 3mihA-4iwmA:
undetectable		 3mihA-4iwmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A  71
GLU A 225
ASP A 107
SER A 177
 None
 1.16A 4apjA-4iwmA:
undetectable
4apjP-4iwmA:
undetectable		 4apjA-4iwmA:
17.83
4apjP-4iwmA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A 180
ASP A 200
GLY A 199
VAL A 216
 None
 0.76A 4c5nC-4iwmA:
undetectable		 4c5nC-4iwmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A 103
LEU A  49
GLU A 225
LEU A 229
ASP A 107
 None
 1.14A 4r88B-4iwmA:
undetectable		 4r88B-4iwmA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A 103
LEU A  49
GLU A 225
LEU A 229
ASP A 107
 None
 1.15A 4r88C-4iwmA:
undetectable		 4r88C-4iwmA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A 103
LEU A  49
GLU A 225
LEU A 229
ASP A 107
 None
 1.15A 4r88D-4iwmA:
undetectable		 4r88D-4iwmA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A 103
LEU A  49
GLU A 225
LEU A 229
ASP A 107
 None
 1.12A 4r88E-4iwmA:
undetectable		 4r88E-4iwmA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A 103
LEU A  49
GLU A 225
LEU A 229
ASP A 107
 None
 1.15A 4r88F-4iwmA:
undetectable		 4r88F-4iwmA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 177
GLY A 178
HIS A  71
ASP A  50
LEU A  49
 None
 1.13A 5eeiA-4iwmA:
undetectable		 5eeiA-4iwmA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 177
GLY A 178
HIS A  71
ASP A  50
LEU A  49
 None
 1.13A 5eeiB-4iwmA:
undetectable		 5eeiB-4iwmA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
LEU A 247
ALA A  48
ILE A  56
LEU A  74
 None
 1.18A 5h8tA-4iwmA:
undetectable		 5h8tA-4iwmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		4 / 5 PHE A  68
LEU A 113
GLY A 112
ILE A  15
 None
 1.01A 5ik1A-4iwmA:
undetectable		 5ik1A-4iwmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A  18
ALA A  19
ALA A 219
LEU A 117
THR A 104
 None
 0.80A 5tl8A-4iwmA:
undetectable		 5tl8A-4iwmA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 4iwm UPF0135 PROTEIN
MJ0927
(Methanocaldococc
us
jannaschii) 		4 / 4 LYS A 206
LEU A 201
ALA A 209
LEU A 181
 None
 1.28A 6gnrB-4iwmA:
undetectable		 6gnrB-4iwmA:
20.08