SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  81
TYR A 348
GLY A 323
VAL A 391
LEU A 330
 None
 0.86A 1vptA-4iwsA:
undetectable		 1vptA-4iwsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4iws PA0254
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 152
PRO A  67
ALA A  68
ILE A 321
 None
 0.84A 2aofA-4iwsA:
undetectable		 2aofA-4iwsA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4iws PA0254
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 193
GLN A 290
PRO A 291
 None
 0.87A 2qhfA-4iwsA:
undetectable		 2qhfA-4iwsA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4iws PA0254
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 144
GLY A 287
GLY A 274
 None
 0.41A 3bogC-4iwsA:
undetectable		 3bogC-4iwsA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 364
ALA A 334
THR A 381
VAL A 378
ARG A 377
 None
 1.18A 3cwkA-4iwsA:
undetectable		 3cwkA-4iwsA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 4iws PA0254
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 316
VAL A 310
CYH A 309
 None
 0.95A 3fbxA-4iwsA:
undetectable		 3fbxA-4iwsA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 209
GLY A 210
LEU A 306
ALA A  61
PHE A 134
 None
 1.07A 3gwwA-4iwsA:
undetectable		 3gwwA-4iwsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 12 SER A 165
ILE A 192
LEU A 199
ASP A 160
GLY A 161
 None
 1.11A 3k2hA-4iwsA:
undetectable		 3k2hA-4iwsA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 12 SER A 165
ILE A 192
LEU A 199
ASP A 160
GLY A 161
 None
 1.15A 3k2hB-4iwsA:
undetectable		 3k2hB-4iwsA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4iws PA0254
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  13
ARG A  17
ARG A 301
 None
 1.02A 3k37A-4iwsA:
undetectable		 3k37A-4iwsA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 11 ILE A  54
ILE A  37
ALA A  30
ILE A 308
VAL A  63
 None
 0.85A 3kw4A-4iwsA:
undetectable		 3kw4A-4iwsA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 155
VAL A 243
VAL A 233
GLY A 231
ALA A 230
 None
 0.99A 3pghC-4iwsA:
undetectable		 3pghC-4iwsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 155
VAL A 243
VAL A 233
GLY A 231
ALA A 230
 None
 0.89A 3rr3A-4iwsA:
undetectable		 3rr3A-4iwsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 155
VAL A 243
VAL A 233
GLY A 231
ALA A 230
 None
 0.89A 3rr3B-4iwsA:
undetectable		 3rr3B-4iwsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 155
VAL A 243
VAL A 233
GLY A 231
ALA A 230
 None
 0.89A 3rr3C-4iwsA:
undetectable		 3rr3C-4iwsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 155
VAL A 243
VAL A 233
GLY A 231
ALA A 230
 None
 0.89A 3rr3D-4iwsA:
undetectable		 3rr3D-4iwsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 11 SER A 165
ILE A 192
LEU A 199
ASP A 160
GLY A 161
 None
 1.22A 4fogC-4iwsA:
undetectable		 4fogC-4iwsA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 11 ILE A  54
ILE A  37
ALA A  30
ILE A 308
VAL A  63
 None
 0.77A 4h1nA-4iwsA:
undetectable		 4h1nA-4iwsA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iws PA0254
(Pseudomonas
aeruginosa) 		3 / 3 SER A   4
ASP A  20
ASP A  73
 None
 0.80A 4mwzA-4iwsA:
undetectable		 4mwzA-4iwsA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 4iws PA0254
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 429
GLY A 449
VAL A 435
HIS A 389
 None
 0.98A 4oltA-4iwsA:
undetectable		 4oltA-4iwsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 4iws PA0254
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 429
GLY A 449
VAL A 435
HIS A 389
 None
 0.96A 4oltB-4iwsA:
undetectable		 4oltB-4iwsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4iws PA0254
(Pseudomonas
aeruginosa) 		3 / 3 PRO A  47
VAL A  24
HIS A  25
 None
 0.84A 4pevC-4iwsA:
undetectable		 4pevC-4iwsA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4iws PA0254
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  15
ARG A  17
ARG A  16
 None
 0.96A 4yiaB-4iwsA:
undetectable		 4yiaB-4iwsA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 155
VAL A 243
VAL A 233
GLY A 231
ALA A 230
 None
 0.96A 5iktA-4iwsA:
undetectable		 5iktA-4iwsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 243
ALA A   5
VAL A 233
GLY A 231
ALA A 230
 None
 1.11A 5kirB-4iwsA:
undetectable		 5kirB-4iwsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4iws PA0254
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 189
ILE A 191
VAL A 156
ILE A 192
PRO A 111
 None
 1.15A 6hlpA-4iwsA:
undetectable		 6hlpA-4iwsA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4iws PA0254
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 259
LEU A 209
ARG A 133
THR A 132
 None
 1.14A 6nmfN-4iwsA:
undetectable
6nmfW-4iwsA:
undetectable		 6nmfN-4iwsA:
21.72
6nmfW-4iwsA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4iws PA0254
(Pseudomonas
aeruginosa) 		6 / 12 PRO A  67
LEU A  64
ILE A 305
LEU A 209
PHE A   8
ILE A 259
 None
 1.48A 6qxsB-4iwsA:
undetectable		 6qxsB-4iwsA:
18.94