SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1B2I_A_AMHA84_1 (PROTEIN (PLASMINOGEN))	4iwt	LYTIC AMIDASE (Streptococcus pneumoniae)	4 / 7	TYR A 230 ASP A 232 GLU A 236 PHE A 251	None	1.12A	1b2iA-4iwtA: undetectable	1b2iA-4iwtA: 19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X8O_A_OINA1317_1 (CHOLINE-BINDING PROTEIN F)	4iwt	LYTIC AMIDASE (Streptococcus pneumoniae)	4 / 4	TRP A 220 TRP A 228 TYR A 249 MET A 257	CHT A 401 (-3.5A) CHT A 401 (-3.9A) None CHT A 401 ( 4.4A)	0.38A	2x8oA-4iwtA: 7.2	2x8oA-4iwtA: 24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X8O_A_OINA1317_1 (CHOLINE-BINDING PROTEIN F)	4iwt	LYTIC AMIDASE (Streptococcus pneumoniae)	4 / 4	TRP A 241 TRP A 248 TYR A 269 MET A 278	CHT A 402 (-3.5A) CHT A 402 (-3.7A) CHT A 402 (-4.2A) CHT A 402 ( 3.8A)	0.74A	2x8oA-4iwtA: 7.2	2x8oA-4iwtA: 24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X8P_A_OINA1313_1 (CHOLINE-BINDING PROTEIN F)	4iwt	LYTIC AMIDASE (Streptococcus pneumoniae)	4 / 4	TRP A 220 LYS A 222 TRP A 228 TYR A 249	CHT A 401 (-3.5A) None CHT A 401 (-3.9A) None	0.38A	2x8pA-4iwtA: 7.4	2x8pA-4iwtA: 24.76

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1B2I_A_AMHA84_1","PROTEIN (PLASMINOGEN)","4iwt","LYTIC AMIDASE","Streptococcus pneumoniae",4,"TYR A 230;ASP A 232;GLU A 236;PHE A 251","None","1.12A","1b2iA-4iwtA:undetectable","1b2iA-4iwtA:19.12"],["2X8O_A_OINA1317_1","CHOLINE-BINDING PROTEIN F","4iwt","LYTIC AMIDASE","Streptococcus pneumoniae",4,"TRP A 220;TRP A 228;TYR A 249;MET A 257","CHT A 401 (-3.5A);CHT A 401 (-3.9A);None;CHT A 401 ( 4.4A)","0.38A","2x8oA-4iwtA:7.2","2x8oA-4iwtA:24.76"],["2X8O_A_OINA1317_1","CHOLINE-BINDING PROTEIN F","4iwt","LYTIC AMIDASE","Streptococcus pneumoniae",4,"TRP A 241;TRP A 248;TYR A 269;MET A 278","CHT A 402 (-3.5A);CHT A 402 (-3.7A);CHT A 402 (-4.2A);CHT A 402 ( 3.8A)","0.74A","2x8oA-4iwtA:7.2","2x8oA-4iwtA:24.76"],["2X8P_A_OINA1313_1","CHOLINE-BINDING PROTEIN F","4iwt","LYTIC AMIDASE","Streptococcus pneumoniae",4,"TRP A 220;LYS A 222;TRP A 228;TYR A 249","CHT A 401 (-3.5A);None;CHT A 401 (-3.9A);None","0.38A","2x8pA-4iwtA:7.4","2x8pA-4iwtA:24.76"]]