SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ix1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 12 TYR A 146
GLU A 121
VAL A 120
ILE A 155
ILE A 204
 None
 1.11A 1fkbA-4ix1A:
undetectable		 1fkbA-4ix1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 12 TYR A 146
GLU A 121
VAL A 120
ILE A 155
ILE A 204
 None
 1.08A 1fklA-4ix1A:
undetectable		 1fklA-4ix1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 12 ILE A 217
ILE A 119
LEU A 150
VAL A 157
ILE A 133
 None
 1.07A 1oipA-4ix1A:
undetectable		 1oipA-4ix1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		4 / 6 SER A 233
ILE A 229
ALA A 122
ALA A 113
 None
 0.99A 1w0gA-4ix1A:
undetectable		 1w0gA-4ix1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		4 / 5 LEU A  30
GLY A 244
PRO A  35
ALA A  34
 None
 0.96A 2aohA-4ix1A:
undetectable		 2aohA-4ix1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 11 TYR A 146
GLU A 121
VAL A 120
ILE A 155
ILE A 204
 None
 1.03A 2dg3A-4ix1A:
undetectable		 2dg3A-4ix1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 11 TYR A 146
GLU A 121
VAL A 120
ILE A 155
ILE A 204
 None
 1.10A 2dg4A-4ix1A:
undetectable		 2dg4A-4ix1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		6 / 10 THR A  20
LEU A  30
VAL A  15
GLY A  16
GLY A  80
GLN A  81
 None
 1.42A 2wd9C-4ix1A:
3.4		 2wd9C-4ix1A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		4 / 5 ARG A  32
ASP A 215
ILE A 216
GLU A  29
 None
 1.05A 2xrzA-4ix1A:
undetectable
2xrzB-4ix1A:
undetectable		 2xrzA-4ix1A:
19.42
2xrzB-4ix1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 9 GLY A  75
ASP A  77
ILE A  78
GLY A  39
LEU A  71
 None
 0.95A 3ogpA-4ix1A:
undetectable		 3ogpA-4ix1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		4 / 7 LEU A  30
VAL A  33
PRO A  35
TYR A   9
 None
 0.95A 4lb2A-4ix1A:
undetectable		 4lb2A-4ix1A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 12 ALA A 234
SER A 118
GLY A 116
ALA A 210
GLY A 208
 None
 1.09A 4r29A-4ix1A:
undetectable		 4r29A-4ix1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 12 ALA A 234
SER A 118
GLY A 116
ALA A 210
GLY A 208
 None
 1.10A 4r29B-4ix1A:
undetectable		 4r29B-4ix1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 12 ALA A 234
SER A 118
GLY A 116
ALA A 210
GLY A 208
 None
 1.09A 4r29C-4ix1A:
undetectable		 4r29C-4ix1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 12 ALA A 234
SER A 118
GLY A 116
ALA A 210
GLY A 208
 None
 1.10A 4r29D-4ix1A:
undetectable		 4r29D-4ix1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 12 GLY A 153
VAL A 157
LEU A  94
VAL A 120
LEU A 117
 None
 0.97A 5ubbA-4ix1A:
undetectable		 5ubbA-4ix1A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 12 ASP A 232
LEU A  71
VAL A  76
GLU A  24
PHE A  44
 None
 1.08A 5uxdB-4ix1A:
undetectable		 5uxdB-4ix1A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGB_B_PQNB844_1
(PSAB)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 9 ILE A  78
MET A 214
TRP A 252
ALA A  34
LEU A  30
 None
 1.33A 5zgbB-4ix1A:
undetectable		 5zgbB-4ix1A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGH_B_PQNB843_1
(PSAB)		 4ix1 HYPOTHETICAL PROTEIN
(Rhodococcus
opacus) 		5 / 9 ILE A  78
MET A 214
TRP A 252
ALA A  34
LEU A  30
 None
 1.33A 5zghB-4ix1A:
0.0		 5zghB-4ix1A:
11.49