SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ix3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		4 / 4 THR A 277
LEU A 280
VAL A 269
LEU A 324
 None
 1.11A 1fbmB-4ix3A:
undetectable		 1fbmB-4ix3A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		4 / 7 GLY A 184
PRO A 177
PHE A 187
ASN A 201
 None
 0.93A 1oniG-4ix3A:
undetectable
1oniI-4ix3A:
undetectable		 1oniG-4ix3A:
20.68
1oniI-4ix3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		4 / 6 ARG A 416
LEU A 454
PHE A 451
ALA A 452
 None
 0.78A 1ukbA-4ix3A:
undetectable		 1ukbA-4ix3A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		3 / 3 SER A 402
ASP A 396
CYH A 345
 None
 0.95A 2br4E-4ix3A:
undetectable		 2br4E-4ix3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		7 / 12 GLY A 179
VAL A 186
ASP A 318
LYS A 320
ALA A 322
ASN A 323
ASP A 338
 None
None
MG  A 601 (-3.1A)
MG  A 601 ( 4.6A)
None
MG  A 601 ( 4.4A)
MG  A 601 (-2.6A)
 0.93A 2fumA-4ix3A:
22.3		 2fumA-4ix3A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		7 / 12 LEU A 178
GLY A 179
VAL A 186
LYS A 320
ALA A 322
ASN A 323
ASP A 338
 None
None
None
MG  A 601 ( 4.6A)
None
MG  A 601 ( 4.4A)
MG  A 601 (-2.6A)
 0.90A 2fumA-4ix3A:
22.3		 2fumA-4ix3A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		5 / 12 THR A 295
ALA A 298
GLU A 301
LEU A 302
LEU A 334
 None
 0.83A 2jfaA-4ix3A:
undetectable		 2jfaA-4ix3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		4 / 4 ARG A 364
ASP A 318
ASP A 362
PRO A 363
 None
MG  A 601 (-3.1A)
None
None
 1.43A 3fgrB-4ix3A:
undetectable		 3fgrB-4ix3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		5 / 12 ASP A 338
GLY A 359
ALA A 342
ALA A 343
CYH A 345
 MG  A 601 (-2.6A)
None
None
None
None
 0.96A 3keeA-4ix3A:
undetectable		 3keeA-4ix3A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		5 / 12 ASP A 338
GLY A 359
ALA A 342
ALA A 343
CYH A 345
 MG  A 601 (-2.6A)
None
None
None
None
 0.99A 3sufD-4ix3A:
undetectable		 3sufD-4ix3A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		4 / 5 LEU A 373
ARG A 317
PRO A 360
ALA A 361
 None
 1.34A 3vm4A-4ix3A:
undetectable		 3vm4A-4ix3A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		4 / 8 VAL A 186
VAL A 198
ILE A 337
ASP A 338
 None
None
None
MG  A 601 (-2.6A)
 0.47A 3warA-4ix3A:
15.3		 3warA-4ix3A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		5 / 9 SER A 180
GLY A 181
ASP A 205
GLY A 184
THR A 185
 None
 1.11A 4lb0A-4ix3A:
undetectable		 4lb0A-4ix3A:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		5 / 12 LEU A 336
ALA A 361
GLY A 404
ALA A 403
LEU A 302
 None
 1.06A 5jw1A-4ix3A:
undetectable		 5jw1A-4ix3A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		4 / 8 VAL A 186
VAL A 198
ILE A 337
ASP A 338
 None
None
None
MG  A 601 (-2.6A)
 0.48A 5y9mX-4ix3A:
4.1		 5y9mX-4ix3A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		5 / 7 VAL A 186
VAL A 198
LYS A 200
ILE A 337
ASP A 338
 None
None
None
None
MG  A 601 (-2.6A)
 1.09A 5yf9B-4ix3A:
20.7		 5yf9B-4ix3A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		5 / 9 LEU A 178
VAL A 186
VAL A 198
ILE A 337
ASP A 338
 None
None
None
None
MG  A 601 (-2.6A)
 0.87A 5yf9X-4ix3A:
21.1		 5yf9X-4ix3A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		4 / 7 VAL A 186
VAL A 198
ILE A 337
ASP A 338
 None
None
None
MG  A 601 (-2.6A)
 0.36A 5ywmX-4ix3A:
21.2		 5ywmX-4ix3A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		4 / 6 LEU A 306
LEU A 302
TYR A 365
LEU A 468
 None
 1.06A 6f6sA-4ix3A:
undetectable
6f6sB-4ix3A:
0.1		 6f6sA-4ix3A:
13.62
6f6sB-4ix3A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		5 / 11 GLY A 420
GLY A 414
LEU A 408
VAL A 412
ASP A 427
 None
 1.21A 6i5zD-4ix3A:
undetectable		 6i5zD-4ix3A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4ix3 MSSTT7D PROTEIN
(Micromonas
commoda) 		4 / 7 ASP A 474
ARG A 397
ASP A 396
CYH A 345
 None
 1.31A 6mn5E-4ix3A:
undetectable		 6mn5E-4ix3A:
14.29