SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ix8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		4 / 8 THR A 424
VAL A 431
ASN A 433
ALA A 353
 None
 0.97A 2ij7C-4ix8A:
undetectable		 2ij7C-4ix8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		4 / 6 PHE A 266
PHE A 129
GLY A 282
GLY A 283
 None
 0.87A 2qr2A-4ix8A:
undetectable
2qr2B-4ix8A:
2.3		 2qr2A-4ix8A:
18.49
2qr2B-4ix8A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		4 / 5 GLY A 282
GLY A 283
PHE A 266
PHE A 129
 None
 0.90A 2qr2A-4ix8A:
undetectable
2qr2B-4ix8A:
2.3		 2qr2A-4ix8A:
18.49
2qr2B-4ix8A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		4 / 7 ASN A  86
LEU A  87
THR A  82
VAL A 289
 None
None
None
LLP  A 286 ( 3.7A)
 1.17A 2uz2A-4ix8A:
undetectable		 2uz2A-4ix8A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		4 / 7 ILE A 239
VAL A 219
CYH A 202
TYR A 192
 None
 1.32A 2xz5D-4ix8A:
undetectable
2xz5E-4ix8A:
undetectable		 2xz5D-4ix8A:
19.63
2xz5E-4ix8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		5 / 9 VAL A 150
ILE A 255
ILE A 220
ALA A 157
ILE A 154
 LLP  A 286 ( 3.3A)
LLP  A 286 ( 3.8A)
None
None
None
 1.03A 3el0B-4ix8A:
undetectable		 3el0B-4ix8A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		4 / 6 ILE A 255
PHE A 266
ALA A 257
ASN A 222
 LLP  A 286 ( 3.8A)
None
None
None
 1.14A 3pgyA-4ix8A:
22.9
3pgyB-4ix8A:
23.4		 3pgyA-4ix8A:
22.08
3pgyB-4ix8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		4 / 8 TYR A 125
TRP A 126
TYR A 287
TRP A 297
 None
 1.42A 3wipD-4ix8A:
undetectable
3wipE-4ix8A:
undetectable		 3wipD-4ix8A:
19.55
3wipE-4ix8A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		4 / 4 ALA A 333
VAL A 122
GLY A 283
THR A 284
 None
 1.07A 4ubeA-4ix8A:
2.6		 4ubeA-4ix8A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		5 / 12 GLY A 282
GLY A 283
THR A 284
PHE A 266
PHE A 129
 None
 1.23A 4zvmA-4ix8A:
2.4
4zvmB-4ix8A:
2.6		 4zvmA-4ix8A:
18.49
4zvmB-4ix8A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		5 / 12 ILE A 280
GLY A 282
VAL A 181
CYH A 182
LEU A 158
 None
 1.19A 5ergB-4ix8A:
undetectable		 5ergB-4ix8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		5 / 12 ILE A 154
VAL A 170
ALA A 172
GLY A 412
PHE A 378
 None
 1.23A 5igiA-4ix8A:
undetectable		 5igiA-4ix8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		5 / 12 GLY A 282
VAL A 122
ALA A 257
PHE A 129
VAL A 269
 None
 1.03A 5n0tB-4ix8A:
1.2		 5n0tB-4ix8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		4 / 5 ASN A  59
TYR A 398
VAL A 409
LEU A 421
 None
 1.16A 6a7pA-4ix8A:
undetectable		 6a7pA-4ix8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		5 / 12 VAL A 407
VAL A 409
PHE A 397
HIS A 446
ILE A 366
 None
 1.31A 6mxtA-4ix8A:
undetectable		 6mxtA-4ix8A:
21.11