SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ixa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4ixa RESPONSE REGULATOR
SAER
(Staphylococcus
epidermidis) 		5 / 11 LEU A 178
LEU A 161
VAL A 172
GLY A 170
LYS A 181
 None
 1.05A 1y4lB-4ixaA:
undetectable		 1y4lB-4ixaA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4ixa RESPONSE REGULATOR
SAER
(Staphylococcus
epidermidis) 		5 / 10 LEU A 138
ALA A 166
ILE A 215
LEU A 165
ILE A 201
 None
 1.14A 1yi4A-4ixaA:
undetectable		 1yi4A-4ixaA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 4ixa RESPONSE REGULATOR
SAER
(Staphylococcus
epidermidis) 		4 / 6 SER A 167
ARG A 168
PHE A 225
ILE A 215
 None
 1.21A 2qeiA-4ixaA:
undetectable		 2qeiA-4ixaA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4ixa RESPONSE REGULATOR
SAER
(Staphylococcus
epidermidis) 		3 / 3 GLU A 206
HIS A 199
GLU A 203
 None
 0.62A 2x45B-4ixaA:
undetectable		 2x45B-4ixaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4ixa RESPONSE REGULATOR
SAER
(Staphylococcus
epidermidis) 		3 / 3 GLU A 206
HIS A 199
GLU A 203
 None
 0.59A 2x45C-4ixaA:
undetectable		 2x45C-4ixaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 4ixa RESPONSE REGULATOR
SAER
(Staphylococcus
epidermidis) 		5 / 12 ALA A 191
GLU A 180
LEU A 178
ASP A 186
TYR A 185
 None
 1.30A 5vlmF-4ixaA:
2.2		 5vlmF-4ixaA:
16.85