SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ixj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4ixj FIMBRIAL PROTEIN
(PILIN)
(Clostridioides
difficile) 		4 / 7 LEU A 131
ILE A 132
PHE A 135
PRO A 192
 None
None
None
GOL  A 305 ( 4.9A)
 0.86A 1oniB-4ixjA:
undetectable
1oniC-4ixjA:
undetectable		 1oniB-4ixjA:
18.82
1oniC-4ixjA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4ixj FIMBRIAL PROTEIN
(PILIN)
(Clostridioides
difficile) 		4 / 6 VAL A 201
TRP A 224
MET A 120
THR A 182
 None
 1.39A 2x2iA-4ixjA:
undetectable		 2x2iA-4ixjA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4ixj FIMBRIAL PROTEIN
(PILIN)
(Clostridioides
difficile) 		3 / 3 ASP A 138
PHE A 135
LEU A 131
 None
 0.66A 2zi9A-4ixjA:
undetectable		 2zi9A-4ixjA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4ixj FIMBRIAL PROTEIN
(PILIN)
(Clostridioides
difficile) 		4 / 7 TYR A 219
TYR A 217
ASP A 239
TYR A 108
 None
None
GOL  A 303 (-3.4A)
None
 1.48A 5ov9B-4ixjA:
undetectable		 5ov9B-4ixjA:
17.47