SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ixl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		5 / 12 ILE A  45
GLY A 184
LEU A  81
ASP A  98
VAL A  97
 None
 1.16A 1zq9A-4ixlA:
undetectable		 1zq9A-4ixlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		5 / 11 GLY A  25
SER A  26
PHE A  47
LEU A  46
ASP A  20
 None
 1.21A 2c2bE-4ixlA:
undetectable
2c2bF-4ixlA:
undetectable		 2c2bE-4ixlA:
17.54
2c2bF-4ixlA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		5 / 12 ILE A 200
LEU A  62
PHE A 162
PHE A  94
VAL A  83
 None
 1.00A 2ygpA-4ixlA:
undetectable		 2ygpA-4ixlA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		4 / 5 SER A 188
GLU A  38
THR A  40
TYR A  24
 None
 1.26A 3zs3A-4ixlA:
undetectable		 3zs3A-4ixlA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		4 / 8 GLU A 122
TYR A 121
ARG A 147
GLY A 118
 None
 0.92A 4fgzA-4ixlA:
undetectable
4fgzB-4ixlA:
undetectable		 4fgzA-4ixlA:
19.03
4fgzB-4ixlA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		3 / 3 TRP A 100
GLN A 186
THR A 102
 None
 1.03A 4m2xA-4ixlA:
undetectable		 4m2xA-4ixlA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		4 / 4 ILE A 134
ARG A  48
TYR A 176
GLU A 177
 None
 1.30A 4zzbD-4ixlA:
undetectable		 4zzbD-4ixlA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		4 / 8 TYR A 124
ARG A 128
GLN A 142
TRP A 144
 None
 0.90A 5tzoA-4ixlA:
24.6		 5tzoA-4ixlA:
41.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		4 / 8 TYR A 124
THR A 126
GLN A 142
TRP A 144
 None
 0.64A 5tzoA-4ixlA:
24.6		 5tzoA-4ixlA:
41.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		5 / 8 TYR A 124
THR A 126
ARG A 128
GLN A 142
TRP A 144
 None
 0.95A 5tzoB-4ixlA:
24.7		 5tzoB-4ixlA:
41.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		4 / 8 TYR A 124
ARG A 128
GLN A 142
TRP A 144
 None
 0.81A 5tzoC-4ixlA:
24.5		 5tzoC-4ixlA:
41.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		4 / 8 TYR A 124
THR A 126
GLN A 142
TRP A 144
 None
 0.62A 5tzoC-4ixlA:
24.5		 5tzoC-4ixlA:
41.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		4 / 5 GLY A 101
THR A 102
SER A 188
SER A 187
 None
 0.85A 6jmjA-4ixlA:
undetectable		 6jmjA-4ixlA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		4 / 7 GLY A 101
THR A 102
SER A 188
SER A 187
 None
 0.83A 6jnhA-4ixlA:
undetectable		 6jnhA-4ixlA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4ixl XYLANASE
(Bacillus
sp.
(in:
Bacteria)) 		4 / 6 GLY A 101
THR A 102
SER A 188
SER A 187
 None
 0.83A 6jogA-4ixlA:
undetectable		 6jogA-4ixlA:
17.74