SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ixo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		4 / 8 SER A 348
ASN A 287
ILE A 258
GLY A 198
 None
 0.88A 1meiA-4ixoA:
undetectable		 1meiA-4ixoA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 9 ILE A 180
GLY A  56
TYR A  64
ILE A 182
ALA A 190
 None
 1.29A 1mrgA-4ixoA:
undetectable		 1mrgA-4ixoA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		4 / 7 PHE A 175
ALA A  54
ILE A 207
ILE A  57
 None
 0.88A 1oniD-4ixoA:
undetectable
1oniF-4ixoA:
undetectable		 1oniD-4ixoA:
19.15
1oniF-4ixoA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 ILE A 111
PHE A 167
ILE A 180
VAL A 119
ILE A 156
 None
 1.10A 1r5lA-4ixoA:
undetectable		 1r5lA-4ixoA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 GLY A 148
ASN A 144
LEU A   4
ARG A 344
ASP A 355
 None
 1.27A 2b9eA-4ixoA:
3.2		 2b9eA-4ixoA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 PHE A  19
LEU A  23
ILE A 237
ALA A 238
THR A  46
 None
 1.14A 2g78A-4ixoA:
undetectable		 2g78A-4ixoA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 LEU A 290
THR A 289
LEU A   4
ILE A 293
LEU A 269
 None
 1.00A 2ouzA-4ixoA:
undetectable		 2ouzA-4ixoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		3 / 3 ARG A 177
ASN A 264
THR A 289
 None
 0.83A 2q63A-4ixoA:
undetectable		 2q63A-4ixoA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		4 / 7 GLY A 203
GLY A 194
GLU A 224
ALA A 236
 None
LLP  A 196 ( 4.4A)
None
None
 0.82A 3fpjB-4ixoA:
2.6		 3fpjB-4ixoA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		3 / 3 ASP A  85
PHE A  83
SER A 134
 None
 0.90A 3i5uB-4ixoA:
undetectable		 3i5uB-4ixoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		3 / 3 SER A  71
GLY A  72
THR A  73
 LLP  A 196 ( 3.8A)
LLP  A 196 ( 3.5A)
LLP  A 196 ( 3.6A)
 0.18A 3k9wA-4ixoA:
undetectable		 3k9wA-4ixoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 PHE A 167
PHE A 240
PHE A 175
GLY A 241
ILE A  57
 None
 1.47A 3ld6B-4ixoA:
undetectable		 3ld6B-4ixoA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		4 / 6 VAL A 172
SER A 193
THR A 191
GLY A  72
 LLP  A 196 ( 4.3A)
LLP  A 196 ( 2.7A)
None
LLP  A 196 ( 3.5A)
 1.15A 3tj7C-4ixoA:
undetectable
3tj7D-4ixoA:
undetectable		 3tj7C-4ixoA:
20.17
3tj7D-4ixoA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 9 ILE A 293
ALA A 298
SER A 346
ILE A 345
ILE A 291
 None
 1.05A 3tq8A-4ixoA:
2.1		 3tq8A-4ixoA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		4 / 8 GLY A 241
ARG A  48
PHE A 175
ILE A 192
 None
 0.97A 4j4vC-4ixoA:
undetectable		 4j4vC-4ixoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 GLY A 241
GLY A 199
ILE A 237
ALA A 236
ARG A  48
 None
 1.09A 4kicB-4ixoA:
undetectable		 4kicB-4ixoA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 9 ILE A 197
GLY A 198
ILE A  12
ILE A 237
VAL A  47
 LLP  A 196 ( 4.0A)
None
None
None
None
 1.07A 4nptA-4ixoA:
undetectable		 4nptA-4ixoA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		6 / 11 GLY A 203
ALA A 236
ILE A  20
ILE A  12
GLY A 198
ILE A 197
 None
None
None
None
None
LLP  A 196 ( 4.0A)
 1.41A 4q1xA-4ixoA:
undetectable		 4q1xA-4ixoA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 LEU A  55
ILE A  51
ALA A 205
ILE A 197
PHE A 240
 None
None
None
LLP  A 196 ( 4.0A)
None
 1.25A 4rp8C-4ixoA:
undetectable		 4rp8C-4ixoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 GLY A 117
ILE A  93
GLU A  94
VAL A 149
ILE A 141
 None
 0.98A 4uw0A-4ixoA:
undetectable		 4uw0A-4ixoA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		3 / 5 GLY A 333
GLY A 335
GLU A 338
 None
 0.51A 4z2eA-4ixoA:
undetectable
4z2eD-4ixoA:
undetectable		 4z2eA-4ixoA:
22.74
4z2eD-4ixoA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		4 / 8 ALA A   8
HIS A  95
ASN A 145
ARG A 344
 None
LLP  A 196 ( 3.6A)
LLP  A 196 ( 4.2A)
None
 0.39A 5db5A-4ixoA:
40.4
5db5B-4ixoA:
40.1		 5db5A-4ixoA:
25.84
5db5B-4ixoA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 ILE A 197
GLY A 176
THR A 248
ALA A 243
VAL A  16
 LLP  A 196 ( 4.0A)
None
None
None
None
 1.13A 5hw4A-4ixoA:
1.5		 5hw4A-4ixoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 ILE A 197
GLY A 176
THR A 248
ALA A 243
VAL A  16
 LLP  A 196 ( 4.0A)
None
None
None
None
 1.07A 5hw4C-4ixoA:
1.1		 5hw4C-4ixoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 LEU A 302
PHE A 305
TYR A 367
LEU A 269
LEU A 265
 None
 1.24A 5ieoA-4ixoA:
undetectable		 5ieoA-4ixoA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 LEU A 302
PHE A 305
TYR A 367
LEU A 269
LEU A 265
 None
 1.23A 5iepA-4ixoA:
undetectable		 5iepA-4ixoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 10 VAL A 275
PHE A 363
LEU A 265
ILE A 345
THR A 289
 None
 1.41A 6d9hR-4ixoA:
undetectable		 6d9hR-4ixoA:
11.84