SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ixu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 167
VAL A 164
VAL A 295
ASP A 293
 None
 1.17A 1dz4B-4ixuA:
undetectable		 1dz4B-4ixuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLN A 215
ILE A 127
HIS A 247
 None
 0.74A 1fm9A-4ixuA:
undetectable		 1fm9A-4ixuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLN A 215
ILE A 127
HIS A 247
 None
 0.73A 1k74A-4ixuA:
undetectable		 1k74A-4ixuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 184
GLY A  93
ILE A 124
SER A 128
 None
 0.80A 1mrjA-4ixuA:
undetectable		 1mrjA-4ixuA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A  65
LEU A  54
LEU A  61
GLY A  62
 None
None
None
BME  A 404 ( 4.7A)
 0.86A 1n13D-4ixuA:
undetectable
1n13E-4ixuA:
undetectable		 1n13D-4ixuA:
17.71
1n13E-4ixuA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ASP A 256
GLY A 276
ILE A 279
ILE A 252
 None
 0.94A 1n49D-4ixuA:
undetectable		 1n49D-4ixuA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU A  43
ASP A  70
ILE A  49
GLY A 118
SER A  34
 None
 1.46A 1q8jA-4ixuA:
2.6		 1q8jA-4ixuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.29A 1v8bA-4ixuA:
2.1		 1v8bA-4ixuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.30A 1v8bB-4ixuA:
2.0		 1v8bB-4ixuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.28A 1v8bD-4ixuA:
undetectable		 1v8bD-4ixuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A  44
ASP A 119
ASN A 158
 None
 0.84A 1wg8B-4ixuA:
undetectable		 1wg8B-4ixuA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU A 171
LEU A 168
ILE A 193
LEU A 209
ILE A 208
 None
 1.28A 2f78B-4ixuA:
1.1		 2f78B-4ixuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU A 171
LEU A 168
ILE A 193
LEU A 209
ILE A 208
 None
 1.25A 2f7aA-4ixuA:
undetectable		 2f7aA-4ixuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ILE A 252
LEU A 248
VAL A 318
ALA A 315
VAL A 114
 None
 0.94A 2nnjA-4ixuA:
undetectable		 2nnjA-4ixuA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.95A 2v2gA-4ixuA:
undetectable
2v2gB-4ixuA:
undetectable		 2v2gA-4ixuA:
20.87
2v2gB-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.98A 2v2gA-4ixuA:
undetectable
2v2gB-4ixuA:
undetectable		 2v2gA-4ixuA:
20.87
2v2gB-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.99A 2v2gC-4ixuA:
undetectable
2v2gD-4ixuA:
undetectable		 2v2gC-4ixuA:
20.87
2v2gD-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.99A 2v2gC-4ixuA:
undetectable
2v2gD-4ixuA:
undetectable		 2v2gC-4ixuA:
20.87
2v2gD-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.99A 2v32A-4ixuA:
undetectable
2v32B-4ixuA:
undetectable		 2v32A-4ixuA:
20.87
2v32B-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.99A 2v32A-4ixuA:
undetectable
2v32B-4ixuA:
undetectable		 2v32A-4ixuA:
20.87
2v32B-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.95A 2v32C-4ixuA:
undetectable
2v32D-4ixuA:
undetectable		 2v32C-4ixuA:
20.87
2v32D-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.99A 2v41E-4ixuA:
undetectable
2v41F-4ixuA:
undetectable		 2v41E-4ixuA:
20.87
2v41F-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 9 ILE A  29
ALA A 100
VAL A 103
CYH A 113
 None
 0.98A 2vufB-4ixuA:
undetectable		 2vufB-4ixuA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.28A 3ce6D-4ixuA:
undetectable		 3ce6D-4ixuA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PRO A 151
VAL A 175
THR A 126
GLY A 125
 None
 1.17A 3elzB-4ixuA:
undetectable		 3elzB-4ixuA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A  86
PRO A 151
VAL A  92
GLY A  93
 None
 0.92A 3em0B-4ixuA:
undetectable		 3em0B-4ixuA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.28A 3g1uB-4ixuA:
2.0		 3g1uB-4ixuA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.33A 3g1uD-4ixuA:
undetectable		 3g1uD-4ixuA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_A_DMOA551_1
(ARGINASE-1)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 HIS A 145
ASN A 149
SER A 155
ASP A 202
GLU A 205
 MN  A 402 ( 3.3A)
38I  A 406 (-4.2A)
38I  A 406 ( 3.7A)
38I  A 406 (-3.1A)
38I  A 406 ( 4.0A)
 1.25A 3gn0A-4ixuA:
54.6		 3gn0A-4ixuA:
60.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_A_DMOA551_1
(ARGINASE-1)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		9 / 9 HIS A 145
ASP A 147
ASN A 149
SER A 156
HIS A 160
GLY A 161
ASP A 202
GLU A 205
THR A 265
 MN  A 402 ( 3.3A)
38I  A 406 ( 2.5A)
38I  A 406 (-4.2A)
38I  A 406 (-2.7A)
38I  A 406 (-3.5A)
38I  A 406 ( 3.7A)
38I  A 406 (-3.1A)
38I  A 406 ( 4.0A)
38I  A 406 (-3.7A)
 0.27A 3gn0A-4ixuA:
54.6		 3gn0A-4ixuA:
60.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_B_DMOB552_1
(ARGINASE-1)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 HIS A 145
ASN A 149
SER A 155
ASP A 202
GLU A 205
 MN  A 402 ( 3.3A)
38I  A 406 (-4.2A)
38I  A 406 ( 3.7A)
38I  A 406 (-3.1A)
38I  A 406 ( 4.0A)
 1.21A 3gn0B-4ixuA:
54.7		 3gn0B-4ixuA:
60.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_B_DMOB552_1
(ARGINASE-1)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		9 / 9 HIS A 145
ASP A 147
ASN A 149
SER A 156
HIS A 160
GLY A 161
ASP A 202
GLU A 205
THR A 265
 MN  A 402 ( 3.3A)
38I  A 406 ( 2.5A)
38I  A 406 (-4.2A)
38I  A 406 (-2.7A)
38I  A 406 (-3.5A)
38I  A 406 ( 3.7A)
38I  A 406 (-3.1A)
38I  A 406 ( 4.0A)
38I  A 406 (-3.7A)
 0.26A 3gn0B-4ixuA:
54.7		 3gn0B-4ixuA:
60.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.29A 3n58C-4ixuA:
2.4		 3n58C-4ixuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.30A 3ondA-4ixuA:
undetectable		 3ondA-4ixuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.30A 3ondB-4ixuA:
2.5		 3ondB-4ixuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 246
ALA A 291
ILE A 188
ARG A 169
ARG A 244
 None
 1.25A 3ql3A-4ixuA:
undetectable		 3ql3A-4ixuA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A 160
THR A 154
PHE A 166
SER A 156
VAL A  87
 38I  A 406 (-3.5A)
None
None
38I  A 406 (-2.7A)
None
 1.35A 3u9fM-4ixuA:
undetectable
3u9fO-4ixuA:
undetectable		 3u9fM-4ixuA:
22.92
3u9fO-4ixuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 275
GLY A 276
TYR A 278
GLU A 281
 None
 1.49A 3w9tA-4ixuA:
undetectable		 3w9tA-4ixuA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 275
GLY A 276
TYR A 278
GLU A 281
 None
 1.49A 3w9tC-4ixuA:
undetectable		 3w9tC-4ixuA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 275
GLY A 276
TYR A 278
GLU A 281
 None
 1.48A 3w9tD-4ixuA:
undetectable		 3w9tD-4ixuA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 275
GLY A 276
TYR A 278
GLU A 281
 None
 1.48A 3w9tG-4ixuA:
undetectable		 3w9tG-4ixuA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL A 164
CYH A 187
ILE A 193
ILE A 127
 None
 0.98A 4afgD-4ixuA:
undetectable
4afgE-4ixuA:
undetectable		 4afgD-4ixuA:
22.26
4afgE-4ixuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 238
GLY A 197
MET A 231
THR A 234
GLY A 276
 None
 0.90A 4dc3A-4ixuA:
3.9		 4dc3A-4ixuA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ASP A 202
ASP A 251
ASP A 147
GLU A 205
 38I  A 406 (-3.1A)
MN  A 402 (-2.8A)
38I  A 406 ( 2.5A)
38I  A 406 ( 4.0A)
 1.29A 4gkhJ-4ixuA:
undetectable		 4gkhJ-4ixuA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  61
GLY A 324
GLN A 325
VAL A 318
ARG A  57
 None
 1.25A 4olmA-4ixuA:
undetectable		 4olmA-4ixuA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 143
ASP A 147
ASN A 158
 MN  A 401 (-2.5A)
38I  A 406 ( 2.5A)
None
 0.82A 4q5mA-4ixuA:
undetectable		 4q5mA-4ixuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A  67
LEU A 116
GLY A  30
 None
 0.37A 4xmfA-4ixuA:
undetectable		 4xmfA-4ixuA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.30A 5axdA-4ixuA:
2.2		 5axdA-4ixuA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.30A 5axdC-4ixuA:
2.1		 5axdC-4ixuA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A 322
PHE A 323
GLY A 324
PHE A 250
 None
 0.92A 5flcB-4ixuA:
undetectable		 5flcB-4ixuA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A 322
PHE A 323
GLY A 324
PHE A 250
 None
 0.92A 5flcF-4ixuA:
undetectable		 5flcF-4ixuA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 VAL A 295
GLU A 296
GLY A 118
LEU A 122
 None
38I  A 406 (-3.8A)
None
None
 1.34A 5g5gC-4ixuA:
undetectable		 5g5gC-4ixuA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.26A 5m5kB-4ixuA:
undetectable		 5m5kB-4ixuA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.31A 5m66A-4ixuA:
undetectable		 5m66A-4ixuA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.29A 5m66C-4ixuA:
3.1		 5m66C-4ixuA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.29A 5utuF-4ixuA:
undetectable		 5utuF-4ixuA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LEU A  58
VAL A 316
ASP A 317
 BME  A 404 (-4.6A)
None
None
 0.62A 5x23A-4ixuA:
undetectable		 5x23A-4ixuA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 250
ILE A 252
LEU A 116
GLY A 117
ALA A  47
 None
 1.08A 5x66A-4ixuA:
undetectable
5x66B-4ixuA:
undetectable		 5x66A-4ixuA:
22.09
5x66B-4ixuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 250
ILE A 252
LEU A 116
GLY A 117
ALA A  47
 None
 1.15A 5x66F-4ixuA:
undetectable		 5x66F-4ixuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A  30
VAL A  28
GLY A 117
GLU A  43
ALA A  47
 None
 1.23A 5x7fA-4ixuA:
3.0		 5x7fA-4ixuA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 246
ALA A 291
ILE A 188
ARG A 169
ARG A 244
 None
 1.26A 5z6fA-4ixuA:
undetectable		 5z6fA-4ixuA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.26A 6f3nB-4ixuA:
2.6		 6f3nB-4ixuA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ASP A  79
ARG A  90
GLU A  98
ARG A 132
 None
 1.26A 6fbvD-4ixuA:
undetectable		 6fbvD-4ixuA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU A 137
VAL A 139
SER A 165
LEU A 168
ILE A 193
 None
 1.25A 6fdyU-4ixuA:
undetectable		 6fdyU-4ixuA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ASP A 253
PHE A 255
ILE A 252
LEU A 314
MET A 219
 MN  A 402 ( 2.0A)
None
None
None
None
 1.44A 6fgcA-4ixuA:
undetectable		 6fgcA-4ixuA:
15.71