SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ixw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ixw HALOHYDRIN
DEHALOGENASE
(Agrobacterium
tumefaciens) 		4 / 6 GLY A 151
VAL A 101
ALA A 148
SER A 147
 None
 1.03A 1p6kA-4ixwA:
undetectable		 1p6kA-4ixwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 4ixw HALOHYDRIN
DEHALOGENASE
(Agrobacterium
tumefaciens) 		3 / 3 PRO A 196
THR A 194
PRO A 191
 None
 0.83A 2d55C-4ixwA:
undetectable		 2d55C-4ixwA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4ixw HALOHYDRIN
DEHALOGENASE
(Agrobacterium
tumefaciens) 		4 / 6 ALA A 150
ALA A 174
PRO A 175
THR A 131
 None
None
IXW  A 302 (-4.6A)
None
 0.71A 4dtzA-4ixwA:
undetectable		 4dtzA-4ixwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4ixw HALOHYDRIN
DEHALOGENASE
(Agrobacterium
tumefaciens) 		4 / 6 ALA A 150
ALA A 174
PRO A 175
THR A 131
 None
None
IXW  A 302 (-4.6A)
None
 0.71A 4dtzB-4ixwA:
undetectable		 4dtzB-4ixwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4ixw HALOHYDRIN
DEHALOGENASE
(Agrobacterium
tumefaciens) 		5 / 7 ALA A 134
ALA A 150
ALA A 174
PRO A 175
THR A 131
 IXW  A 302 (-3.5A)
None
None
IXW  A 302 (-4.6A)
None
 1.04A 4du2A-4ixwA:
undetectable		 4du2A-4ixwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4ixw HALOHYDRIN
DEHALOGENASE
(Agrobacterium
tumefaciens) 		5 / 7 ALA A 134
ALA A 150
ALA A 174
PRO A 175
THR A 131
 IXW  A 302 (-3.5A)
None
None
IXW  A 302 (-4.6A)
None
 1.06A 4du2B-4ixwA:
undetectable		 4du2B-4ixwA:
20.89