SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		5 / 11 GLY A 106
VAL A 145
SER A  82
ASP A 109
ILE A 110
 None
 1.23A 1pk9C-4iyjA:
5.7		 1pk9C-4iyjA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		4 / 7 SER A  82
VAL A 145
ILE A 126
ASP A 109
 None
 1.08A 2x45B-4iyjA:
undetectable		 2x45B-4iyjA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		4 / 7 SER A  82
VAL A 145
ILE A 126
ASP A 109
 None
 1.08A 2x45C-4iyjA:
undetectable		 2x45C-4iyjA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		4 / 7 SER A  82
VAL A 145
ILE A 126
ASP A 109
 None
 1.06A 3bu1A-4iyjA:
undetectable		 3bu1A-4iyjA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		6 / 12 ILE A 171
ALA A 169
GLN A 166
PHE A 123
LEU A 167
ILE A 180
 None
None
None
None
None
CL  A 302 ( 4.9A)
 1.46A 3oapA-4iyjA:
undetectable		 3oapA-4iyjA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		4 / 5 GLY A  78
GLY A  79
ASN A 113
GLU A  57
 None
 1.13A 4fglC-4iyjA:
3.6		 4fglC-4iyjA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		4 / 7 ILE A  55
THR A 107
VAL A  60
PHE A  85
 UNL  A 301 ( 4.8A)
UNL  A 301 ( 3.8A)
None
None
 1.02A 4iarA-4iyjA:
undetectable		 4iarA-4iyjA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		5 / 11 PHE A 123
ILE A 171
ASN A 168
TYR A 174
TYR A 121
 None
 1.41A 4rtrA-4iyjA:
4.2		 4rtrA-4iyjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		4 / 5 PHE A 151
PRO A 155
VAL A 157
ALA A 150
 None
 1.01A 4w5oA-4iyjA:
4.5		 4w5oA-4iyjA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		4 / 4 ASN A 194
SER A 199
ALA A 196
VAL A 190
 None
 1.40A 4x1kC-4iyjA:
undetectable		 4x1kC-4iyjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		3 / 3 LYS A  43
ARG A  75
VAL A  93
 None
 0.98A 4x3uA-4iyjA:
undetectable
4x3uB-4iyjA:
undetectable		 4x3uA-4iyjA:
21.14
4x3uB-4iyjA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		4 / 5 PHE A 151
PRO A 155
VAL A 157
ALA A 150
 None
 1.00A 4z4cA-4iyjA:
4.4		 4z4cA-4iyjA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		4 / 5 PHE A 151
PRO A 155
VAL A 157
ALA A 150
 None
 1.01A 4z4dA-4iyjA:
undetectable		 4z4dA-4iyjA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		4 / 5 PHE A 151
PRO A 155
VAL A 157
ALA A 150
 None
 1.00A 4z4eA-4iyjA:
4.4		 4z4eA-4iyjA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		5 / 12 ILE A 103
VAL A 102
GLY A  52
PHE A  50
LEU A  96
 None
 0.95A 5ergB-4iyjA:
undetectable		 5ergB-4iyjA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		5 / 12 GLY A  52
ASN A  53
GLU A 120
ALA A 111
ILE A 171
 None
UNL  A 301 ( 2.5A)
None
None
None
 1.10A 5igyA-4iyjA:
undetectable		 5igyA-4iyjA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4iyj GDSL-LIKE PROTEIN
(Bacteroides
uniformis) 		4 / 6 PHE A 151
PRO A 155
VAL A 157
ALA A 150
 None
 0.98A 5t7bA-4iyjA:
4.6		 5t7bA-4iyjA:
14.15