SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		4 / 8 LEU A 193
ALA A 136
PHE A 138
VAL A 127
 None
 0.80A 1epbB-4iykA:
undetectable		 1epbB-4iykA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 9 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.47A 1q6iA-4iykA:
undetectable		 1q6iA-4iykA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 10 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.45A 1q6iB-4iykA:
undetectable		 1q6iB-4iykA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 10 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.37A 3kz7A-4iykA:
undetectable		 3kz7A-4iykA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 11 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.42A 3o5rA-4iykA:
undetectable		 3o5rA-4iykA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 10 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.38A 3uf8A-4iykA:
undetectable		 3uf8A-4iykA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 10 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.40A 3uqaA-4iykA:
undetectable		 3uqaA-4iykA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 11 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.37A 3vawA-4iykA:
undetectable		 3vawA-4iykA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 10 ALA A 201
LEU A 197
LEU A 170
ASN A 171
ILE A 134
 None
 1.14A 3wdmB-4iykA:
undetectable		 3wdmB-4iykA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 11 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.36A 4dz2A-4iykA:
undetectable
4dz2B-4iykA:
undetectable		 4dz2A-4iykA:
21.83
4dz2B-4iykA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 11 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.38A 4dz2A-4iykA:
undetectable
4dz2B-4iykA:
undetectable		 4dz2A-4iykA:
21.83
4dz2B-4iykA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 10 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.38A 4dz3A-4iykA:
undetectable		 4dz3A-4iykA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 10 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.38A 4dz3B-4iykA:
undetectable		 4dz3B-4iykA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 10 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.43A 4laxA-4iykA:
undetectable		 4laxA-4iykA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 10 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.39A 4nnrB-4iykA:
undetectable		 4nnrB-4iykA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 12 LEU A 140
ALA A 216
ILE A 214
ALA A 231
ILE A 152
 None
 0.97A 4o2bD-4iykA:
undetectable		 4o2bD-4iykA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 10 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.37A 4qt2A-4iykA:
undetectable		 4qt2A-4iykA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 11 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.31A 5hwcA-4iykA:
undetectable		 5hwcA-4iykA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 10 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.42A 6mkeC-4iykA:
undetectable		 6mkeC-4iykA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4iyk UNCHARACTERIZED
PROTEIN
(Bacteroides
uniformis) 		5 / 10 VAL A 111
ILE A  30
TYR A  76
ILE A  53
PHE A 103
 None
 1.39A 6mkeD-4iykA:
undetectable		 6mkeD-4iykA:
15.11