SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 11 HIS B 215
SER B 190
LEU B 212
LEU B 261
THR B 260
 None
 1.28A 1dmyA-4iyoB:
undetectable		 1dmyA-4iyoB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 11 ILE B 379
GLY B 342
GLU B 344
HIS B 268
LEU B 385
 None
 1.42A 1i7qA-4iyoB:
undetectable		 1i7qA-4iyoB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 12 ILE B 222
LEU B 203
ALA B 223
PHE B  85
THR B 115
 None
 1.22A 1og5B-4iyoB:
undetectable		 1og5B-4iyoB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 4 GLY B 292
SER B 295
VAL B 313
LEU B 273
 None
 1.30A 1yajB-4iyoB:
undetectable		 1yajB-4iyoB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 12 LEU B 118
PHE B 133
VAL B 105
LEU B 129
ARG B 123
 None
 1.33A 2bxfB-4iyoB:
undetectable		 2bxfB-4iyoB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 12 GLY B 220
ALA B  91
THR B  92
ALA B  84
ALA B 208
 None
 1.02A 2gluB-4iyoB:
2.3		 2gluB-4iyoB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 6 PHE B 131
PHE B 133
GLY B 114
GLY B 113
 None
 0.99A 2qr2A-4iyoB:
undetectable
2qr2B-4iyoB:
2.2		 2qr2A-4iyoB:
20.78
2qr2B-4iyoB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 5 GLY B 114
GLY B 113
PHE B 131
PHE B 133
 None
 0.99A 2qr2A-4iyoB:
undetectable
2qr2B-4iyoB:
2.0		 2qr2A-4iyoB:
20.78
2qr2B-4iyoB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 9 ALA B  91
SER B 251
GLY B 247
SER B  87
ALA B  86
 None
None
None
LLP  B 210 ( 3.7A)
None
 1.38A 2vh3A-4iyoB:
undetectable		 2vh3A-4iyoB:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 5 VAL B 205
VAL B 204
THR B  94
THR B 187
 None
None
None
LLP  B 210 ( 3.8A)
 1.15A 3bjwA-4iyoB:
undetectable		 3bjwA-4iyoB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 5 VAL B 205
VAL B 204
THR B  94
THR B 187
 None
None
None
LLP  B 210 ( 3.8A)
 1.22A 3bjwG-4iyoB:
undetectable		 3bjwG-4iyoB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 5 VAL B 205
VAL B 204
THR B  94
THR B 187
 None
None
None
LLP  B 210 ( 3.8A)
 1.17A 3bjwC-4iyoB:
undetectable		 3bjwC-4iyoB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 5 VAL B 205
VAL B 204
THR B  94
THR B 187
 None
None
None
LLP  B 210 ( 3.8A)
 1.15A 3bjwD-4iyoB:
undetectable		 3bjwD-4iyoB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 4 THR B  94
VAL B 205
GLY B 220
THR B 209
 None
None
None
LLP  B 210 ( 3.5A)
 1.05A 3cflA-4iyoB:
undetectable		 3cflA-4iyoB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 7 GLN B 246
GLY B  88
GLY B 220
ALA B  91
 None
LLP  B 210 ( 3.3A)
None
None
 0.82A 3fpjB-4iyoB:
2.4		 3fpjB-4iyoB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 12 GLN B 246
GLY B  88
GLY B 220
LEU B 212
ALA B  91
 None
LLP  B 210 ( 3.3A)
None
None
None
 0.94A 3kkzA-4iyoB:
undetectable		 3kkzA-4iyoB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 12 GLN B 246
GLY B  88
GLY B 220
LEU B 212
ALA B  91
 None
LLP  B 210 ( 3.3A)
None
None
None
 0.98A 3kkzB-4iyoB:
2.4		 3kkzB-4iyoB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 10 LEU B 212
ALA B  21
ILE B  22
GLY B  25
LEU B 258
 None
 1.03A 3ogpA-4iyoB:
undetectable		 3ogpA-4iyoB:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 6 GLY B  88
VAL B 219
SER B  87
THR B 209
 LLP  B 210 ( 3.3A)
LLP  B 210 ( 4.8A)
LLP  B 210 ( 3.7A)
LLP  B 210 ( 3.5A)
 1.13A 3tj7A-4iyoB:
undetectable
3tj7B-4iyoB:
undetectable		 3tj7A-4iyoB:
18.23
3tj7B-4iyoB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 6 GLY B  88
VAL B 219
SER B  87
THR B 209
 LLP  B 210 ( 3.3A)
LLP  B 210 ( 4.8A)
LLP  B 210 ( 3.7A)
LLP  B 210 ( 3.5A)
 1.12A 3tj7C-4iyoB:
undetectable
3tj7D-4iyoB:
undetectable		 3tj7C-4iyoB:
18.23
3tj7D-4iyoB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 6 VAL B 219
SER B  87
THR B 209
GLY B  88
 LLP  B 210 ( 4.8A)
LLP  B 210 ( 3.7A)
LLP  B 210 ( 3.5A)
LLP  B 210 ( 3.3A)
 1.11A 3tj7C-4iyoB:
undetectable
3tj7D-4iyoB:
undetectable		 3tj7C-4iyoB:
18.23
3tj7D-4iyoB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 7 ALA B 356
ILE B 358
ARG B 121
GLY B 114
 None
 0.86A 3v4tH-4iyoB:
undetectable		 3v4tH-4iyoB:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 12 PRO B 262
LEU B  76
LEU B 255
ILE B  22
PHE B 252
 None
 1.42A 4a79A-4iyoB:
undetectable		 4a79A-4iyoB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 12 PRO B 262
LEU B  76
LEU B 255
ILE B  22
PHE B 252
 None
 1.39A 4a79B-4iyoB:
undetectable		 4a79B-4iyoB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 6 ASP B 109
GLY B 367
PRO B 350
THR B 354
 None
None
None
NAK  B 402 (-3.6A)
 1.04A 4l1aB-4iyoB:
undetectable		 4l1aB-4iyoB:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 5 ASN B 213
SER B 207
LEU B 340
ASN B 160
 None
LLP  B 210 ( 2.6A)
LLP  B 210 (-4.3A)
NAK  B 402 (-3.3A)
 1.12A 4n09C-4iyoB:
undetectable		 4n09C-4iyoB:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 12 LEU B 375
ILE B 285
LEU B 317
ALA B 392
LEU B 389
 None
 1.07A 4o1zB-4iyoB:
undetectable		 4o1zB-4iyoB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 5 GLY B 383
ARG B 386
GLY B 387
GLU B 390
 None
 1.24A 4z2eB-4iyoB:
undetectable
4z2eC-4iyoB:
undetectable		 4z2eB-4iyoB:
23.98
4z2eC-4iyoB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 6 PRO B 158
HIS B 268
GLU B 380
ALA B 274
 None
 1.08A 5igiA-4iyoB:
undetectable		 5igiA-4iyoB:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		3 / 3 HIS B 349
LYS B 325
PHE B 321
 None
 1.12A 5klaA-4iyoB:
undetectable		 5klaA-4iyoB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 4 SER B  87
ALA B  90
GLN B 239
THR B  94
 LLP  B 210 ( 3.7A)
None
None
None
 1.46A 5n0wA-4iyoB:
1.4		 5n0wA-4iyoB:
23.11