SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iyp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 124
ILE A 201
PRO A 127
LEU A 113
 None
 0.74A 1hmyA-4iypA:
undetectable		 1hmyA-4iypA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 7 LEU A 113
ILE A 208
GLN A 213
ALA C 140
 None
 0.84A 2xkwA-4iypA:
undetectable		 2xkwA-4iypA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1
(Homo
sapiens) 		3 / 3 TYR A 193
VAL A 179
THR A  74
 None
 0.73A 2ygnA-4iypA:
undetectable		 2ygnA-4iypA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1
(Homo
sapiens) 		4 / 6 HIS A 196
GLN A 198
LEU A 172
LEU A 168
 None
 1.18A 3bgdA-4iypA:
undetectable		 3bgdA-4iypA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1
(Homo
sapiens) 		4 / 4 THR A  89
VAL A  26
GLY A  19
THR A  18
 None
 0.87A 3cflA-4iypA:
undetectable		 3cflA-4iypA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4iyp SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		3 / 3 LYS C   6
ARG C 106
LYS C  41
 None
 1.35A 3okxA-4iypC:
undetectable		 3okxA-4iypC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A  80
VAL A 121
TYR A 193
TYR A 112
 None
 1.02A 4b3qA-4iypA:
undetectable		 4b3qA-4iypA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1
(Homo
sapiens) 		5 / 10 ARG A 171
MET A 175
ALA A 178
GLU A 187
LEU A 195
 None
 1.19A 4la0A-4iypA:
2.6		 4la0A-4iypA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP C 131
ARG A 221
TYR C 130
 None
 0.96A 5a7mA-4iypC:
undetectable		 5a7mA-4iypC:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP C 131
ARG A 221
TYR C 130
 None
 0.98A 5a7mB-4iypC:
undetectable		 5a7mB-4iypC:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1
(Homo
sapiens) 		4 / 5 GLN A 198
HIS A 196
ILE A 201
ILE A 203
 None
 1.19A 5dnvA-4iypA:
undetectable		 5dnvA-4iypA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A  84
ALA A  87
HIS A 108
LEU A  46
 None
 1.25A 5dzkB-4iypA:
undetectable
5dzkP-4iypA:
undetectable		 5dzkB-4iypA:
22.76
5dzkP-4iypA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 199
LYS A 176
TYR A 192
 None
 1.21A 6gnaA-4iypA:
undetectable		 6gnaA-4iypA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 199
LYS A 176
TYR A 192
 None
 1.21A 6gnbA-4iypA:
undetectable		 6gnbA-4iypA:
20.41