SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4iys METAL TRANSPORTER
CNNM2
(Homo
sapiens) 		4 / 8 GLY A 461
GLU A 462
ALA A 463
ILE A 459
 None
 0.74A 2dtjA-4iysA:
undetectable
2dtjB-4iysA:
undetectable		 2dtjA-4iysA:
23.78
2dtjB-4iysA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4iys METAL TRANSPORTER
CNNM2
(Homo
sapiens) 		5 / 9 THR A 469
LEU A 465
THR A 515
VAL A 483
ILE A 481
 None
 1.24A 2l8mA-4iysA:
undetectable		 2l8mA-4iysA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4iys METAL TRANSPORTER
CNNM2
(Homo
sapiens) 		5 / 12 ILE A 566
THR A 568
ASP A 571
THR A 451
PRO A 482
 None
 0.99A 3kpbA-4iysA:
10.6		 3kpbA-4iysA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4iys METAL TRANSPORTER
CNNM2
(Homo
sapiens) 		5 / 12 ILE A 566
THR A 568
ASP A 571
THR A 451
PRO A 482
 None
 1.00A 3kpbC-4iysA:
10.4		 3kpbC-4iysA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4iys METAL TRANSPORTER
CNNM2
(Homo
sapiens) 		5 / 11 ILE A 566
THR A 568
ASP A 571
THR A 451
PRO A 482
 None
 0.83A 3kpcA-4iysA:
12.1		 3kpcA-4iysA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4iys METAL TRANSPORTER
CNNM2
(Homo
sapiens) 		5 / 12 ILE A 566
THR A 568
ASP A 571
THR A 451
PRO A 482
 None
 0.85A 3kpdB-4iysA:
10.9		 3kpdB-4iysA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4iys METAL TRANSPORTER
CNNM2
(Homo
sapiens) 		5 / 12 ILE A 566
THR A 568
ASP A 571
THR A 451
PRO A 482
 None
 0.80A 3kpdC-4iysA:
11.1		 3kpdC-4iysA:
20.75