SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4izd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		6 / 12 LEU A  71
GLY A 117
ILE A  40
LEU A 122
GLY A 119
GLY A 118
 None
 1.41A 1uakA-4izdA:
undetectable		 1uakA-4izdA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		5 / 11 ALA A 126
LEU A  35
LEU A  43
LEU A  60
LEU A 122
 None
 1.11A 2ceoA-4izdA:
undetectable		 2ceoA-4izdA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		5 / 10 ALA A 126
LEU A  35
LEU A  43
LEU A  60
LEU A 122
 None
 1.14A 2riwA-4izdA:
undetectable
2riwB-4izdA:
undetectable		 2riwA-4izdA:
22.47
2riwB-4izdA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		5 / 7 MET A 159
ALA A 125
ALA A 121
THR A 148
LEU A 139
 None
 1.43A 2wx2A-4izdA:
undetectable		 2wx2A-4izdA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		5 / 10 ALA A 126
LEU A  35
LEU A  43
LEU A  60
LEU A 122
 None
 1.14A 2xn6A-4izdA:
undetectable
2xn6B-4izdA:
undetectable		 2xn6A-4izdA:
22.10
2xn6B-4izdA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		5 / 10 ALA A 126
LEU A  35
LEU A  43
LEU A  60
LEU A 122
 None
 1.13A 2xn7A-4izdA:
undetectable
2xn7B-4izdA:
undetectable		 2xn7A-4izdA:
22.10
2xn7B-4izdA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		4 / 4 ARG A 155
ASP A 167
GLY A 172
THR A 148
 None
 1.27A 3k4vB-4izdA:
undetectable		 3k4vB-4izdA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		5 / 9 MET A 159
ALA A 125
ALA A 121
THR A 148
LEU A 139
 None
 1.46A 3l4dB-4izdA:
undetectable		 3l4dB-4izdA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		5 / 9 MET A 159
ALA A 125
ALA A 121
THR A 148
LEU A 139
 None
 1.46A 3l4dC-4izdA:
undetectable		 3l4dC-4izdA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 PHE A 195
THR A  25
ALA A 198
ALA A 110
 None
 1.08A 3ns1C-4izdA:
undetectable		 3ns1C-4izdA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 THR A  61
ILE A 205
ASP A 196
THR A  25
 None
 0.95A 3q70A-4izdA:
undetectable		 3q70A-4izdA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 THR A 135
GLY A 119
ALA A  63
GLY A  64
ASN A  27
 None
 1.13A 3v3oA-4izdA:
undetectable		 3v3oA-4izdA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		6 / 12 LEU A  71
GLY A 117
ILE A  40
LEU A 122
GLY A 119
GLY A 118
 None
 1.38A 5wyqB-4izdA:
undetectable		 5wyqB-4izdA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 PRO A 140
GLY A  70
LEU A 120
GLY A 119
GLY A 118
 None
1HE  A 301 ( 4.6A)
None
None
None
 0.97A 5wyqB-4izdA:
undetectable		 5wyqB-4izdA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		6 / 12 LEU A  71
GLY A 117
ILE A  40
LEU A 122
GLY A 119
GLY A 118
 None
 1.45A 5zhmB-4izdA:
undetectable		 5zhmB-4izdA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Ruegeria
pomeroyi) 		5 / 10 MET A 159
ALA A 125
ALA A 121
THR A 148
LEU A 139
 None
 1.42A 6ay4A-4izdA:
undetectable		 6ay4A-4izdA:
21.22