SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4izk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
5 / 11 SER A 633
LEU A 636
THR A 655
ILE A 645
ILE A 563
MG  A 801 ( 4.4A)
None
None
None
None
1.15A 1pkvA-4izkA:
undetectable
1pkvB-4izkA:
undetectable
1pkvA-4izkA:
20.59
1pkvB-4izkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
5 / 11 ILE A 563
SER A 633
LEU A 636
THR A 655
ILE A 645
None
MG  A 801 ( 4.4A)
None
None
None
1.16A 1pkvA-4izkA:
undetectable
1pkvB-4izkA:
undetectable
1pkvA-4izkA:
20.59
1pkvB-4izkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
5 / 12 ARG A 515
LEU A 560
PRO A 544
VAL A 653
VAL A 546
None
1.17A 2qd4A-4izkA:
undetectable
2qd4A-4izkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
5 / 12 ARG A 515
LEU A 560
PRO A 544
VAL A 653
VAL A 546
None
1.23A 2qd4B-4izkA:
undetectable
2qd4B-4izkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
4 / 8 GLN A 635
VAL A 589
GLY A 593
GLY A 591
None
0.71A 2vinA-4izkA:
undetectable
2vinA-4izkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
5 / 12 ILE A 665
GLY A 656
GLY A 637
LEU A 640
PHE A 598
None
1.22A 2y7kD-4izkA:
undetectable
2y7kD-4izkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
5 / 12 ALA A 607
LEU A 561
LEU A 610
GLY A 637
LEU A 638
None
1.17A 2yjaB-4izkA:
undetectable
2yjaB-4izkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
4 / 8 ASP A 644
ILE A 563
PRO A 537
THR A 538
None
0.83A 3el9A-4izkA:
undetectable
3el9A-4izkA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
5 / 12 GLY A 687
ASP A 693
ILE A 543
PRO A 650
ILE A 706
None
1.06A 3s56A-4izkA:
undetectable
3s56A-4izkA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
4 / 8 PRO A 537
ILE A 619
ILE A 542
ARG A 651
None
1.10A 3sfeB-4izkA:
undetectable
3sfeC-4izkA:
undetectable
3sfeB-4izkA:
20.08
3sfeC-4izkA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
5 / 11 ALA A 607
LEU A 561
LEU A 610
GLY A 637
LEU A 638
None
1.14A 3uudA-4izkA:
undetectable
3uudA-4izkA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
5 / 11 ALA A 607
LEU A 561
LEU A 610
GLY A 637
LEU A 638
None
1.10A 5dxbB-4izkA:
undetectable
5dxbB-4izkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
5 / 11 ALA A 607
LEU A 561
LEU A 610
GLY A 637
LEU A 638
None
1.12A 5dxgB-4izkA:
undetectable
5dxgB-4izkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites
virus)
4 / 8 LEU A 638
ILE A 592
ALA A 629
PRO A 650
None
0.85A 5m0oC-4izkA:
undetectable
5m0oC-4izkA:
21.45