SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4izo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		4 / 8 SER A 286
SER A 201
ASN A 220
GLN A 219
 None
 1.08A 2cmlC-4izoA:
undetectable		 2cmlC-4izoA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		4 / 5 VAL A  20
THR A  81
VAL A 107
GLY A 104
 None
 1.01A 2p2fA-4izoA:
5.0		 2p2fA-4izoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		4 / 4 VAL A  20
THR A  81
VAL A 107
GLY A 104
 None
 0.98A 2p2fB-4izoA:
5.1		 2p2fB-4izoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		3 / 3 PRO A 281
LEU A 262
ARG A 206
 None
 0.85A 3aqiB-4izoA:
undetectable		 3aqiB-4izoA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		3 / 3 PRO A 342
PHE A 331
ALA A 363
 None
 0.64A 3itaD-4izoA:
undetectable		 3itaD-4izoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		3 / 3 GLN A 167
GLU A 191
LYS A 156
 None
 0.79A 3su9A-4izoA:
undetectable		 3su9A-4izoA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		5 / 12 HIS A  58
GLY A  52
GLY A  21
ALA A  61
ALA A  62
 None
 1.17A 3sueB-4izoA:
undetectable		 3sueB-4izoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		5 / 11 HIS A  58
GLY A  52
GLY A  21
ALA A  61
ALA A  62
 None
 1.16A 3sufC-4izoA:
undetectable		 3sufC-4izoA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		4 / 8 ARG A 282
PRO A 283
GLY A 260
SER A  80
 None
 1.02A 3tzfB-4izoA:
undetectable		 3tzfB-4izoA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		5 / 12 ILE A 120
ALA A 115
PRO A 102
LEU A 262
ILE A 252
 None
 1.01A 4m2xC-4izoA:
5.0		 4m2xC-4izoA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		5 / 12 GLY A 224
SER A 228
LEU A 229
ALA A 390
THR A 387
 None
 1.05A 4uckB-4izoA:
3.0		 4uckB-4izoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		5 / 12 VAL A 232
PRO A 233
ALA A 234
PHE A 266
GLN A 246
 None
 0.99A 5hgcA-4izoA:
undetectable		 5hgcA-4izoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		4 / 8 GLY A  18
ALA A  15
ASP A  56
PHE A  29
 None
 0.87A 5mvsB-4izoA:
4.3		 5mvsB-4izoA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		4 / 7 ALA A 353
THR A 352
GLN A 346
VAL A 347
 None
 0.78A 6cduA-4izoA:
undetectable
6cduE-4izoA:
undetectable		 6cduA-4izoA:
21.35
6cduE-4izoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		4 / 6 GLN A 346
VAL A 347
ALA A 353
THR A 352
 None
 0.96A 6cduB-4izoA:
undetectable
6cduC-4izoA:
undetectable		 6cduB-4izoA:
21.35
6cduC-4izoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		4 / 7 GLN A 346
VAL A 347
ALA A 353
THR A 352
 None
 0.83A 6cduC-4izoA:
undetectable
6cduD-4izoA:
undetectable		 6cduC-4izoA:
21.35
6cduD-4izoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		4 / 7 ALA A 353
THR A 352
GLN A 346
VAL A 347
 None
 0.79A 6cduF-4izoA:
undetectable
6cduJ-4izoA:
undetectable		 6cduF-4izoA:
21.35
6cduJ-4izoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
thailandensis) 		4 / 7 GLN A 346
VAL A 347
ALA A 353
THR A 352
 None
 0.78A 6cduH-4izoA:
undetectable
6cduI-4izoA:
undetectable		 6cduH-4izoA:
21.35
6cduI-4izoA:
21.35