SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j07'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4j07 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Mycobacterium
leprae) 		4 / 8 SER A  25
HIS A  28
ILE A  83
VAL A  93
 None
 1.15A 1kb9A-4j07A:
undetectable
1kb9C-4j07A:
undetectable
1kb9D-4j07A:
undetectable
1kb9E-4j07A:
undetectable		 1kb9A-4j07A:
19.17
1kb9C-4j07A:
21.08
1kb9D-4j07A:
22.54
1kb9E-4j07A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 4j07 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Mycobacterium
leprae) 		5 / 10 ASP A  45
GLY A  12
ILE A  48
LEU A 147
ALA A  15
 None
 1.09A 1x7pA-4j07A:
2.5
1x7pB-4j07A:
undetectable		 1x7pA-4j07A:
20.42
1x7pB-4j07A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 4j07 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Mycobacterium
leprae) 		5 / 11 VAL A  77
GLY A 113
ALA A  75
LEU A  20
SER A  46
 None
 1.23A 2bxgA-4j07A:
2.1		 2bxgA-4j07A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 4j07 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Mycobacterium
leprae) 		4 / 5 LEU A  36
ARG A  40
PRO A  51
ALA A  43
 None
 1.45A 3vm4A-4j07A:
undetectable		 3vm4A-4j07A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4j07 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Mycobacterium
leprae) 		5 / 9 LEU A 101
GLY A 115
VAL A 112
VAL A  66
LEU A  69
 None
 1.05A 4qd3A-4j07A:
undetectable		 4qd3A-4j07A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4j07 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Mycobacterium
leprae) 		5 / 9 ALA A 146
ALA A 143
ALA A  43
SER A  46
ALA A  75
 None
 1.18A 4twdA-4j07A:
undetectable
4twdB-4j07A:
undetectable
4twdC-4j07A:
undetectable
4twdD-4j07A:
undetectable
4twdE-4j07A:
undetectable		 4twdA-4j07A:
21.09
4twdB-4j07A:
21.09
4twdC-4j07A:
21.09
4twdD-4j07A:
21.09
4twdE-4j07A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4j07 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Mycobacterium
leprae) 		4 / 6 SER A 158
ASP A  74
ARG A  19
GLY A  17
 None
 1.08A 5cdqA-4j07A:
undetectable
5cdqC-4j07A:
undetectable
5cdqD-4j07A:
undetectable		 5cdqA-4j07A:
19.70
5cdqC-4j07A:
19.70
5cdqD-4j07A:
25.93