SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		5 / 10 THR A  30
GLY A 188
THR A 185
ALA A 186
VAL A  14
 None
 1.38A 2coiA-4j0eA:
undetectable
2coiB-4j0eA:
undetectable		 2coiA-4j0eA:
24.31
2coiB-4j0eA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		5 / 10 VAL A  14
THR A  30
GLY A 188
THR A 185
ALA A 186
 None
 1.31A 2coiA-4j0eA:
undetectable
2coiB-4j0eA:
undetectable		 2coiA-4j0eA:
24.31
2coiB-4j0eA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		5 / 11 THR A  30
GLY A 188
THR A 185
ALA A 186
VAL A  14
 None
 1.38A 2cojA-4j0eA:
undetectable
2cojB-4j0eA:
undetectable		 2cojA-4j0eA:
24.31
2cojB-4j0eA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		5 / 11 ILE A  99
ILE A 113
PHE A 114
ALA A 103
VAL A  89
 None
 0.97A 3tmzA-4j0eA:
undetectable		 3tmzA-4j0eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		5 / 11 ILE A  99
ILE A 113
PHE A 114
ILE A 100
VAL A  89
 None
 0.96A 3tmzA-4j0eA:
undetectable		 3tmzA-4j0eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		5 / 10 ALA A  50
GLY A  20
LEU A  39
ASP A  41
ILE A  16
 None
 1.17A 3wdmD-4j0eA:
4.2		 3wdmD-4j0eA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		4 / 7 VAL A  17
ILE A  16
LEU A 180
LEU A 152
 None
 1.03A 4l1wA-4j0eA:
undetectable		 4l1wA-4j0eA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		5 / 12 GLY A  18
ALA A 102
ILE A  99
THR A  30
ILE A  26
 None
 1.09A 4njvA-4j0eA:
undetectable		 4njvA-4j0eA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		4 / 5 PHE A 211
PRO A 274
VAL A 276
ALA A 272
 None
 1.29A 4w5oA-4j0eA:
2.4		 4w5oA-4j0eA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		4 / 5 ASP A 291
VAL A 280
ASP A 251
GLY A 249
 None
 1.26A 4xp6A-4j0eA:
undetectable		 4xp6A-4j0eA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		4 / 5 PHE A 211
PRO A 274
VAL A 276
ALA A 272
 None
 1.28A 4z4cA-4j0eA:
3.3		 4z4cA-4j0eA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		4 / 5 PHE A 211
PRO A 274
VAL A 276
ALA A 272
 None
 1.28A 4z4dA-4j0eA:
undetectable		 4z4dA-4j0eA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		4 / 5 PHE A 211
PRO A 274
VAL A 276
ALA A 272
 None
 1.28A 4z4eA-4j0eA:
3.3		 4z4eA-4j0eA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		4 / 5 PHE A 293
PHE A 211
PHE A 210
VAL A 276
 None
 1.12A 5a1rA-4j0eA:
undetectable		 5a1rA-4j0eA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1
(Caenorhabditis
elegans) 		3 / 3 ASN A 203
SER A 132
SER A 133
 None
 0.54A 5gsnA-4j0eA:
4.0		 5gsnA-4j0eA:
20.56