SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 ALA A 172
VAL A 407
TRP A 411
 None
 0.93A 1jnoA-4j0kA:
undetectable		 1jnoA-4j0kA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 ALA A 172
VAL A 407
TRP A 411
 None
 0.93A 1jnoB-4j0kA:
undetectable		 1jnoB-4j0kA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 7 PRO A 130
ALA A 393
TYR A 180
ALA A 386
 None
 1.06A 1k5qA-4j0kA:
undetectable
1k5qB-4j0kA:
undetectable		 1k5qA-4j0kA:
19.21
1k5qB-4j0kA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 ALA A 172
VAL A 407
TRP A 411
 None
 0.94A 1magA-4j0kA:
undetectable		 1magA-4j0kA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 ALA A 172
VAL A 407
TRP A 411
 None
 0.94A 1magB-4j0kA:
undetectable		 1magB-4j0kA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 416
ASP A 456
GLY A 453
SER A 452
HIS A 451
 None
None
None
None
EGR  A 501 (-3.8A)
 1.13A 1nbiA-4j0kA:
2.0		 1nbiA-4j0kA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 416
ASP A 456
GLY A 453
SER A 452
HIS A 451
 None
None
None
None
EGR  A 501 (-3.8A)
 1.14A 1nbiB-4j0kA:
2.0		 1nbiB-4j0kA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 ALA A 172
VAL A 407
TRP A 411
 None
 0.91A 1nruA-4j0kA:
undetectable		 1nruA-4j0kA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 ALA A 172
VAL A 407
TRP A 411
 None
 0.91A 1nruB-4j0kA:
undetectable		 1nruB-4j0kA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 ALA A 172
PHE A 132
LEU A 360
ILE A 394
TYR A 399
 None
 1.13A 1rb2B-4j0kA:
undetectable		 1rb2B-4j0kA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 416
ASP A 421
ILE A 206
ILE A 413
ALA A 425
 None
EGR  A 501 (-3.5A)
EGR  A 501 (-4.0A)
None
None
 1.02A 1sguB-4j0kA:
undetectable		 1sguB-4j0kA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 10 GLY A 416
ASP A 421
ILE A 206
ILE A 413
ALA A 425
 None
EGR  A 501 (-3.5A)
EGR  A 501 (-4.0A)
None
None
 1.00A 1sh9B-4j0kA:
undetectable		 1sh9B-4j0kA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 LEU A 171
SER A 398
LEU A 400
MET A 433
THR A 422
 None
 1.40A 2aa5A-4j0kA:
undetectable		 2aa5A-4j0kA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 9 GLY A  76
GLY A  77
SER A 163
ALA A 164
HIS A 451
 EGR  A 501 (-3.3A)
EGR  A 501 (-3.3A)
EGR  A 501 (-2.6A)
EGR  A 501 (-3.7A)
EGR  A 501 (-3.8A)
 0.55A 2aceA-4j0kA:
19.1		 2aceA-4j0kA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 416
ASP A 421
ILE A 206
ILE A 413
ALA A 425
 None
EGR  A 501 (-3.5A)
EGR  A 501 (-4.0A)
None
None
 1.07A 2b7zA-4j0kA:
undetectable		 2b7zA-4j0kA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 416
ASP A 421
ILE A 206
ILE A 413
ALA A 425
 None
EGR  A 501 (-3.5A)
EGR  A 501 (-4.0A)
None
None
 1.04A 2b7zB-4j0kA:
undetectable		 2b7zB-4j0kA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 LEU A 400
LEU A 397
HIS A 207
ILE A 432
ALA A 431
 None
 1.04A 2bxcA-4j0kA:
undetectable		 2bxcA-4j0kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 11 ILE A 158
LEU A  70
ASP A  85
ILE A  24
VAL A 108
 None
 1.11A 2fxdA-4j0kA:
undetectable		 2fxdA-4j0kA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 8 GLY A  76
GLY A  77
ALA A 164
HIS A 451
 EGR  A 501 (-3.3A)
EGR  A 501 (-3.3A)
EGR  A 501 (-3.7A)
EGR  A 501 (-3.8A)
 0.51A 2ha4A-4j0kA:
19.1		 2ha4A-4j0kA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 7 GLY A  76
GLY A  77
ALA A 164
HIS A 451
 EGR  A 501 (-3.3A)
EGR  A 501 (-3.3A)
EGR  A 501 (-3.7A)
EGR  A 501 (-3.8A)
 0.49A 2ha4B-4j0kA:
19.0		 2ha4B-4j0kA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 6 TYR A 203
ILE A  98
ASN A 160
LEU A  70
 None
 1.37A 2wekB-4j0kA:
2.1		 2wekB-4j0kA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 7 GLY A 152
ILE A 157
GLN A 147
LEU A 150
 None
 0.98A 2xrhA-4j0kA:
undetectable		 2xrhA-4j0kA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 SER A 163
GLU A 357
ASP A 421
 EGR  A 501 (-2.6A)
EGR  A 501 (-2.9A)
EGR  A 501 (-3.5A)
 0.69A 2zthA-4j0kA:
2.4		 2zthA-4j0kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 SER A 163
GLU A 357
ASP A 421
 EGR  A 501 (-2.6A)
EGR  A 501 (-2.9A)
EGR  A 501 (-3.5A)
 0.86A 3bwmA-4j0kA:
2.5		 3bwmA-4j0kA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 SER A 163
GLU A 357
ASP A 421
 EGR  A 501 (-2.6A)
EGR  A 501 (-2.9A)
EGR  A 501 (-3.5A)
 0.76A 3bwyA-4j0kA:
2.2		 3bwyA-4j0kA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 GLU A 357
ASP A 213
ASP A 421
 EGR  A 501 (-2.9A)
None
EGR  A 501 (-3.5A)
 0.72A 3jb2A-4j0kA:
undetectable		 3jb2A-4j0kA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 10 ILE A 206
TRP A 447
ALA A 444
LEU A 445
ALA A 417
 EGR  A 501 (-4.0A)
None
None
None
None
 1.39A 3lw5B-4j0kA:
undetectable		 3lw5B-4j0kA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 7 GLY A  76
GLY A  77
SER A 163
HIS A 451
 EGR  A 501 (-3.3A)
EGR  A 501 (-3.3A)
EGR  A 501 (-2.6A)
EGR  A 501 (-3.8A)
 0.68A 3o9mA-4j0kA:
2.4		 3o9mA-4j0kA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 6 GLY A  76
GLY A  77
SER A 163
HIS A 451
 EGR  A 501 (-3.3A)
EGR  A 501 (-3.3A)
EGR  A 501 (-2.6A)
EGR  A 501 (-3.8A)
 0.76A 3o9mB-4j0kA:
19.2		 3o9mB-4j0kA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 8 ALA A 129
ILE A 394
LEU A 360
ALA A 386
 None
 0.69A 3r9tA-4j0kA:
2.6		 3r9tA-4j0kA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 GLN A  43
THR A 118
GLY A  81
GLY A 115
GLY A 112
 None
 1.13A 3tegA-4j0kA:
undetectable		 3tegA-4j0kA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 5 ILE A 428
ALA A 431
HIS A 415
ARG A 414
 None
 1.12A 4ac9B-4j0kA:
3.7
4ac9C-4j0kA:
3.4		 4ac9B-4j0kA:
20.58
4ac9C-4j0kA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 5 ILE A 428
ALA A 431
HIS A 415
ARG A 414
 None
 1.06A 4acaB-4j0kA:
3.6
4acaC-4j0kA:
3.2		 4acaB-4j0kA:
20.58
4acaC-4j0kA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 8 SER A 163
ILE A 428
VAL A 296
PHE A 424
 EGR  A 501 (-2.6A)
None
None
None
 1.01A 4dx7B-4j0kA:
undetectable		 4dx7B-4j0kA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 7 ASN A  94
GLY A  96
LEU A  70
PHE A 461
 None
 0.86A 4ejjD-4j0kA:
undetectable		 4ejjD-4j0kA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		6 / 12 ILE A 133
ALA A 172
PHE A 132
LEU A 360
ILE A 394
TYR A 399
 None
 1.42A 4kjkA-4j0kA:
undetectable		 4kjkA-4j0kA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 8 PHE A 132
TYR A  78
LEU A 209
ILE A 133
 None
EGR  A 501 (-4.5A)
None
None
 0.89A 4l4cB-4j0kA:
undetectable		 4l4cB-4j0kA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 5 ASN A  73
PRO A  72
GLY A 161
ASP A 153
 None
 1.06A 4n48B-4j0kA:
2.2		 4n48B-4j0kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 ALA A 172
PHE A 132
LEU A 360
ILE A 394
TYR A 399
 None
 1.13A 4nx6A-4j0kA:
undetectable		 4nx6A-4j0kA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 6 VAL A 296
LEU A 300
LEU A 336
PHE A 348
 None
None
PGE  A 502 (-4.7A)
EGR  A 501 ( 4.7A)
 1.09A 4o1zA-4j0kA:
undetectable		 4o1zA-4j0kA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 PHE A 443
TYR A 439
ALA A 202
ALA A 174
GLY A 173
 None
 1.06A 4oaeA-4j0kA:
1.3		 4oaeA-4j0kA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 SER A 163
GLU A 357
ASP A 421
 EGR  A 501 (-2.6A)
EGR  A 501 (-2.9A)
EGR  A 501 (-3.5A)
 0.83A 4xudA-4j0kA:
2.0		 4xudA-4j0kA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 HIS A 207
ILE A 426
LEU A 434
LEU A 400
LEU A 397
 None
 1.26A 4xumA-4j0kA:
undetectable		 4xumA-4j0kA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 PHE A 265
TYR A 268
LEU A 269
ILE A 206
ILE A 429
 None
None
None
EGR  A 501 (-4.0A)
None
 1.10A 5h8tA-4j0kA:
undetectable		 5h8tA-4j0kA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 VAL A 200
GLY A 165
ALA A 164
LEU A 360
LEU A 209
 None
None
EGR  A 501 (-3.7A)
None
None
 1.17A 5x23A-4j0kA:
undetectable		 5x23A-4j0kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 4j0k TANNASE
(Lactobacillus
plantarum) 		6 / 12 ALA A 174
VAL A 200
GLY A 165
ALA A 164
LEU A 360
LEU A 209
 None
None
None
EGR  A 501 (-3.7A)
None
None
 1.33A 5xxiA-4j0kA:
undetectable		 5xxiA-4j0kA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 PRO A 356
LEU A 360
VAL A  75
PRO A 396
LEU A 209
 None
 1.46A 6eliA-4j0kA:
undetectable		 6eliA-4j0kA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 10 VAL A  49
LEU A 102
GLY A 152
GLY A  56
ARG A  64
 None
 1.12A 6eu9B-4j0kA:
undetectable		 6eu9B-4j0kA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 ALA A 172
PHE A 132
LEU A 360
ILE A 394
TYR A 399
 None
 1.08A 7dfrA-4j0kA:
undetectable		 7dfrA-4j0kA:
17.54