SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j0q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		5 / 9 TYR A  70
VAL A 192
ILE A 171
VAL A 132
ILE A 103
 None
 1.13A 1gebA-4j0qA:
undetectable		 1gebA-4j0qA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		4 / 7 ASP A  87
GLY A  16
ILE A 103
THR A 116
 None
 0.84A 1t7jB-4j0qA:
undetectable		 1t7jB-4j0qA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		4 / 5 ALA A  30
ALA A  78
TYR A  77
MET A  99
 None
 1.20A 3d91A-4j0qA:
undetectable		 3d91A-4j0qA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		5 / 11 LEU A 104
ASP A 162
GLY A 127
VAL A 126
ILE A 131
 None
 1.00A 3oxxD-4j0qA:
undetectable		 3oxxD-4j0qA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		4 / 8 GLU A  38
ILE A 103
VAL A 105
PHE A 134
 None
 1.02A 4dx7B-4j0qA:
undetectable		 4dx7B-4j0qA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		4 / 7 THR A  94
ILE A  61
THR A 386
GLY A 388
 None
 0.90A 4eq4A-4j0qA:
undetectable		 4eq4A-4j0qA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		4 / 7 THR A  94
ILE A  61
THR A 386
GLY A 388
 None
 0.91A 4eqlA-4j0qA:
1.6		 4eqlA-4j0qA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		4 / 7 THR A  94
ILE A  61
THR A 386
GLY A 388
 None
 0.94A 4eqlB-4j0qA:
undetectable		 4eqlB-4j0qA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		3 / 3 VAL A 302
GLY A 300
LYS A 298
 None
 0.63A 4k50A-4j0qA:
undetectable		 4k50A-4j0qA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		3 / 3 VAL A 302
GLY A 300
LYS A 298
 None
 0.64A 4k50E-4j0qA:
undetectable		 4k50E-4j0qA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		3 / 3 VAL A 302
GLY A 300
LYS A 298
 None
 0.66A 4k50I-4j0qA:
undetectable		 4k50I-4j0qA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		4 / 7 LEU A 315
THR A 386
THR A  94
GLY A 390
 None
 0.96A 4l39B-4j0qA:
1.5		 4l39B-4j0qA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_I_MTXI301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		5 / 9 PHE A 378
GLY A 321
GLY A 388
LEU A 315
GLU A 319
 None
 1.27A 4l8wI-4j0qA:
4.4		 4l8wI-4j0qA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		5 / 12 ARG A 252
GLY A 284
VAL A 230
ILE A 224
GLY A 226
 None
 1.02A 4njvD-4j0qA:
undetectable		 4njvD-4j0qA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		5 / 12 LEU A 122
LEU A 158
VAL A 133
VAL A 128
PHE A 163
 None
 1.22A 4wnwA-4j0qA:
undetectable		 4wnwA-4j0qA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		4 / 6 ASN A 136
ASP A  22
THR A  17
VAL A 105
 GDP  A 402 (-3.4A)
GDP  A 402 (-3.7A)
None
None
 1.07A 4yoaA-4j0qA:
undetectable		 4yoaA-4j0qA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		4 / 6 ASN A 136
ASP A 110
THR A  17
VAL A 105
 GDP  A 402 (-3.4A)
None
None
None
 1.12A 4yoaA-4j0qA:
undetectable		 4yoaA-4j0qA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		4 / 8 ILE A 218
THR A 285
LEU A 246
THR A 257
 None
 0.72A 5og9A-4j0qA:
undetectable		 5og9A-4j0qA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		4 / 6 GLY A  95
THR A  94
ASN A  91
LYS A  90
 None
 1.05A 5xxiA-4j0qA:
undetectable		 5xxiA-4j0qA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		3 / 3 GLY A 388
VAL A 364
MET A 362
 None
 0.66A 5ycpA-4j0qA:
undetectable		 5ycpA-4j0qA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4j0q ELONGATION FACTOR
TU-A
(Pseudomonas
putida) 		5 / 9 LEU A 135
PRO A 112
VAL A 133
SER A 159
LEU A 157
 None
 1.39A 6fdyU-4j0qA:
undetectable		 6fdyU-4j0qA:
22.09