SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		3 / 3 ASP A 290
LEU A 386
LEU A 332
 None
 0.66A 1ikeA-4j0wA:
undetectable		 1ikeA-4j0wA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		3 / 3 ASP A 290
LEU A 386
LEU A 332
 None
 0.72A 1np1B-4j0wA:
undetectable		 1np1B-4j0wA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 10 ILE A 225
ILE A 223
VAL A 244
GLY A 246
TYR A 257
 None
 1.08A 3em0A-4j0wA:
2.4		 3em0A-4j0wA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		4 / 5 ASN A 387
ARG A 251
HIS A 331
ALA A 384
 None
 1.21A 3frqA-4j0wA:
undetectable		 3frqA-4j0wA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		4 / 7 ASN A 387
ARG A 251
HIS A 331
ALA A 384
 None
 1.24A 3frqB-4j0wA:
undetectable		 3frqB-4j0wA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		4 / 7 ARG A 219
VAL A 183
LEU A 224
ILE A 171
 None
 0.83A 3gp0A-4j0wA:
2.4		 3gp0A-4j0wA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 HIS A 323
GLY A 322
ARG A 401
SER A 340
SER A 395
 None
 1.28A 3sueD-4j0wA:
undetectable		 3sueD-4j0wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_2
(NEURAMINIDASE)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		4 / 5 LEU A 415
ASP A 417
ARG A 401
TRP A 403
 None
 1.37A 4cpzA-4j0wA:
4.4		 4cpzA-4j0wA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.95A 4jksA-4j0wA:
undetectable		 4jksA-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.95A 4jksB-4j0wA:
undetectable		 4jksB-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.94A 4jkuA-4j0wA:
undetectable		 4jkuA-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.94A 4k8cA-4j0wA:
undetectable		 4k8cA-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.95A 4k8cB-4j0wA:
undetectable		 4k8cB-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.96A 4k8kA-4j0wA:
undetectable		 4k8kA-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.95A 4k8kB-4j0wA:
undetectable		 4k8kB-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.94A 4kahA-4j0wA:
undetectable		 4kahA-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.94A 4kahB-4j0wA:
undetectable		 4kahB-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.94A 4kalA-4j0wA:
undetectable		 4kalA-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.94A 4kalB-4j0wA:
undetectable		 4kalB-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.96A 4kanA-4j0wA:
undetectable		 4kanA-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.96A 4kanB-4j0wA:
undetectable		 4kanB-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.94A 4kbeA-4j0wA:
undetectable		 4kbeA-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.93A 4kbeB-4j0wA:
undetectable		 4kbeB-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL A 153
LYS A 212
SER A 208
ILE A 223
LEU A 256
 None
 1.10A 4ky8B-4j0wA:
undetectable		 4ky8B-4j0wA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.95A 4lbgA-4j0wA:
undetectable		 4lbgA-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.95A 4lbgB-4j0wA:
undetectable		 4lbgB-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.94A 4lcaA-4j0wA:
undetectable		 4lcaA-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASN A 457
ILE A 149
GLY A 439
SER A 163
ILE A 161
 None
 0.94A 4lcaB-4j0wA:
undetectable		 4lcaB-4j0wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ALA A 359
ARG A 362
ALA A 364
ALA A 342
GLY A 341
 None
 1.08A 4oaeA-4j0wA:
undetectable		 4oaeA-4j0wA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL A 153
LYS A 212
SER A 208
ILE A 223
LEU A 256
 None
 1.11A 4q0dA-4j0wA:
undetectable		 4q0dA-4j0wA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL A 153
LYS A 212
SER A 208
ILE A 223
LEU A 256
 None
 1.11A 4q0dB-4j0wA:
undetectable		 4q0dB-4j0wA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL A 153
LYS A 212
SER A 208
ILE A 223
LEU A 256
 None
 1.11A 4q0dE-4j0wA:
undetectable		 4q0dE-4j0wA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		4 / 7 LEU A 360
SER A 346
GLY A 325
ALA A 342
 None
 0.67A 4yjiA-4j0wA:
undetectable		 4yjiA-4j0wA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		3 / 3 PRO A 156
ILE A 462
SER A 208
 None
 0.79A 5fsaA-4j0wA:
undetectable		 5fsaA-4j0wA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		4 / 6 GLY A 341
SER A 395
THR A 393
VAL A 347
 None
 1.08A 5ysiA-4j0wA:
undetectable		 5ysiA-4j0wA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens) 		4 / 8 ASP A 343
HIS A 282
ARG A 303
ASP A 284
 None
 1.09A 6mn4A-4j0wA:
undetectable		 6mn4A-4j0wA:
23.25