SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j0x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae)
3 / 3 TRP A 492
ALA A 559
VAL A 520
None
0.98A 1av2C-4j0xA:
undetectable
1av2D-4j0xA:
undetectable
1av2C-4j0xA:
4.73
1av2D-4j0xA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae)
3 / 3 ALA A 517
VAL A 520
TRP A 492
None
1.02A 1gmkC-4j0xA:
undetectable
1gmkD-4j0xA:
undetectable
1gmkC-4j0xA:
4.73
1gmkD-4j0xA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae)
3 / 3 ASP A 323
ARG A 344
ARG A 342
None
0.93A 2j9dA-4j0xA:
undetectable
2j9dC-4j0xA:
undetectable
2j9dA-4j0xA:
14.86
2j9dC-4j0xA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae)
4 / 5 ILE A 402
THR A 435
PHE A 508
PHE A 487
None
1.37A 3em0A-4j0xA:
2.3
3em0A-4j0xA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae)
4 / 6 VAL A 273
HIS A 235
ILE A 261
LEU A 260
None
0.77A 3hegA-4j0xA:
undetectable
3hegA-4j0xA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae)
3 / 3 ARG A 151
THR A 522
THR A 197
None
0.79A 3k2hB-4j0xA:
undetectable
3k2hB-4j0xA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae)
3 / 3 ASP A 403
SER A 401
ARG A 551
None
0.96A 3loqA-4j0xA:
undetectable
3loqA-4j0xA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae)
4 / 6 VAL A 486
LEU A 140
ILE A 142
VAL A 526
None
0.90A 4a9kA-4j0xA:
undetectable
4a9kA-4j0xA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae)
3 / 3 PRO A 246
ILE A 524
SER A 292
None
0.78A 5fsaA-4j0xA:
undetectable
5fsaA-4j0xA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae)
4 / 4 GLY A 362
ASP A 363
ARG A 360
MET A 407
None
1.07A 5gwkB-4j0xA:
undetectable
5gwkB-4j0xA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae)
4 / 4 GLY A 562
LEU A 157
VAL A 152
GLU A 154
None
1.50A 5yw0A-4j0xA:
undetectable
5yw0A-4j0xA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae)
5 / 12 LEU A 268
VAL A 251
GLU A 154
THR A 150
GLY A 562
None
1.29A 6mn8A-4j0xA:
undetectable
6mn8A-4j0xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae)
5 / 12 LEU A 478
LEU A 140
LEU A 496
ILE A 539
ALA A 566
None
1.35A 6qxsD-4j0xA:
undetectable
6qxsD-4j0xA:
20.57