SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j1l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 10 MET A 245
LEU A 242
ALA A 114
LEU A 107
LEU A 350
 None
 1.14A 1gwrA-4j1lA:
undetectable		 1gwrA-4j1lA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 12 HIS A 233
GLU A 234
HIS A 237
GLU A 271
TYR A 375
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.1A)
ZN  A 501 (-3.3A)
ZN  A 501 (-1.9A)
None
 0.70A 1j36A-4j1lA:
undetectable		 1j36A-4j1lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 12 HIS A 233
GLU A 234
HIS A 237
GLU A 271
TYR A 375
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.1A)
ZN  A 501 (-3.3A)
ZN  A 501 (-1.9A)
None
 0.71A 1j36B-4j1lA:
2.0		 1j36B-4j1lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 11 HIS A 233
GLU A 234
HIS A 237
GLU A 271
TYR A 375
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.1A)
ZN  A 501 (-3.3A)
ZN  A 501 (-1.9A)
None
 0.68A 1j37A-4j1lA:
2.7		 1j37A-4j1lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 11 HIS A 233
GLU A 234
HIS A 237
GLU A 271
TYR A 375
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.1A)
ZN  A 501 (-3.3A)
ZN  A 501 (-1.9A)
None
 0.69A 1j37B-4j1lA:
2.5		 1j37B-4j1lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 12 HIS A 233
GLU A 234
HIS A 237
GLU A 271
TYR A 375
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.1A)
ZN  A 501 (-3.3A)
ZN  A 501 (-1.9A)
None
 0.74A 1o86A-4j1lA:
2.5		 1o86A-4j1lA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 GLU A 271
HIS A 233
HIS A 237
GLU A 234
 ZN  A 501 (-1.9A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.1A)
 0.82A 1v7zA-4j1lA:
undetectable		 1v7zA-4j1lA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 GLU A 271
HIS A 233
HIS A 237
GLU A 234
 ZN  A 501 (-1.9A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.1A)
 0.82A 1v7zB-4j1lA:
undetectable		 1v7zB-4j1lA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 GLU A 271
HIS A 233
HIS A 237
GLU A 234
 ZN  A 501 (-1.9A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.1A)
 0.83A 1v7zC-4j1lA:
undetectable		 1v7zC-4j1lA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 GLU A 271
HIS A 233
HIS A 237
GLU A 234
 ZN  A 501 (-1.9A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.1A)
 0.84A 1v7zD-4j1lA:
undetectable		 1v7zD-4j1lA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 GLU A 271
HIS A 233
HIS A 237
GLU A 234
 ZN  A 501 (-1.9A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.1A)
 0.84A 1v7zE-4j1lA:
undetectable		 1v7zE-4j1lA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 GLU A 271
HIS A 233
HIS A 237
GLU A 234
 ZN  A 501 (-1.9A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.1A)
 0.84A 1v7zF-4j1lA:
undetectable		 1v7zF-4j1lA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 GLY A 173
THR A 155
ILE A 174
SER A 192
 None
 1.06A 2a8tB-4j1lA:
undetectable		 2a8tB-4j1lA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 12 HIS A 233
GLU A 234
HIS A 237
GLU A 271
TYR A 375
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.1A)
ZN  A 501 (-3.3A)
ZN  A 501 (-1.9A)
None
 0.66A 2c6nA-4j1lA:
2.9		 2c6nA-4j1lA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 12 HIS A 233
GLU A 234
HIS A 237
GLU A 271
TYR A 375
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.1A)
ZN  A 501 (-3.3A)
ZN  A 501 (-1.9A)
None
 0.72A 2c6nB-4j1lA:
undetectable		 2c6nB-4j1lA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 11 HIS A 233
GLU A 234
HIS A 237
GLU A 271
TYR A 375
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.1A)
ZN  A 501 (-3.3A)
ZN  A 501 (-1.9A)
None
 0.67A 2x8zA-4j1lA:
2.2		 2x8zA-4j1lA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 12 HIS A 233
GLU A 234
HIS A 237
GLU A 271
TYR A 375
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.1A)
ZN  A 501 (-3.3A)
ZN  A 501 (-1.9A)
None
 0.69A 2x91A-4j1lA:
undetectable		 2x91A-4j1lA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 GLU A 271
HIS A 233
HIS A 237
GLU A 234
 ZN  A 501 (-1.9A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.1A)
 0.82A 3a6jA-4j1lA:
undetectable		 3a6jA-4j1lA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 7 GLU A 271
HIS A 233
HIS A 237
GLU A 234
 ZN  A 501 (-1.9A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.1A)
 0.80A 3a6jB-4j1lA:
undetectable		 3a6jB-4j1lA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 GLU A 271
HIS A 233
HIS A 237
GLU A 234
 ZN  A 501 (-1.9A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.1A)
 0.82A 3a6jC-4j1lA:
undetectable		 3a6jC-4j1lA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 GLU A 271
HIS A 233
HIS A 237
GLU A 234
 ZN  A 501 (-1.9A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.1A)
 0.83A 3a6jE-4j1lA:
undetectable		 3a6jE-4j1lA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 GLU A 271
HIS A 233
HIS A 237
GLU A 234
 ZN  A 501 (-1.9A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.1A)
 0.82A 3a6jF-4j1lA:
undetectable		 3a6jF-4j1lA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		3 / 3 HIS A 233
GLU A 234
HIS A 237
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.1A)
ZN  A 501 (-3.3A)
 0.19A 3kecB-4j1lA:
undetectable		 3kecB-4j1lA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 12 LEU A 235
ILE A  98
LEU A 108
ASP A 109
SER A 353
 None
 0.92A 3ko0A-4j1lA:
undetectable
3ko0B-4j1lA:
undetectable
3ko0C-4j1lA:
undetectable
3ko0D-4j1lA:
undetectable		 3ko0A-4j1lA:
14.29
3ko0B-4j1lA:
14.29
3ko0C-4j1lA:
14.29
3ko0D-4j1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 12 SER A 353
LEU A 235
ILE A  98
LEU A 108
ASP A 109
 None
 0.91A 3ko0G-4j1lA:
undetectable
3ko0H-4j1lA:
undetectable
3ko0I-4j1lA:
undetectable
3ko0J-4j1lA:
undetectable		 3ko0G-4j1lA:
14.29
3ko0H-4j1lA:
14.29
3ko0I-4j1lA:
14.29
3ko0J-4j1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 12 LEU A 235
ILE A  98
LEU A 108
ASP A 109
SER A 353
 None
 0.95A 3ko0K-4j1lA:
undetectable
3ko0L-4j1lA:
undetectable
3ko0S-4j1lA:
undetectable
3ko0T-4j1lA:
undetectable		 3ko0K-4j1lA:
14.29
3ko0L-4j1lA:
14.29
3ko0S-4j1lA:
14.29
3ko0T-4j1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 12 LEU A 108
ASP A 109
LEU A 235
ILE A  98
SER A 353
 None
 0.95A 3ko0K-4j1lA:
undetectable
3ko0L-4j1lA:
undetectable
3ko0M-4j1lA:
undetectable
3ko0N-4j1lA:
undetectable		 3ko0K-4j1lA:
14.29
3ko0L-4j1lA:
14.29
3ko0M-4j1lA:
14.29
3ko0N-4j1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 12 LEU A 235
ILE A  98
LEU A 108
ASP A 109
SER A 353
 None
 0.86A 3ko0M-4j1lA:
undetectable
3ko0N-4j1lA:
undetectable
3ko0O-4j1lA:
undetectable
3ko0P-4j1lA:
undetectable		 3ko0M-4j1lA:
14.29
3ko0N-4j1lA:
14.29
3ko0O-4j1lA:
14.29
3ko0P-4j1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 12 SER A 353
LEU A 108
ASP A 109
LEU A 235
ILE A  98
 None
 0.84A 3ko0M-4j1lA:
undetectable
3ko0N-4j1lA:
undetectable
3ko0O-4j1lA:
undetectable
3ko0P-4j1lA:
undetectable		 3ko0M-4j1lA:
14.29
3ko0N-4j1lA:
14.29
3ko0O-4j1lA:
14.29
3ko0P-4j1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 ILE A 369
TYR A 394
LEU A 388
PHE A 400
 None
 1.04A 3rqwI-4j1lA:
undetectable
3rqwJ-4j1lA:
undetectable		 3rqwI-4j1lA:
18.64
3rqwJ-4j1lA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 11 ILE A  43
ILE A  98
PHE A 198
ILE A 159
VAL A 238
 None
 0.91A 3tmzA-4j1lA:
1.5		 3tmzA-4j1lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 11 ILE A  98
PHE A 198
ILE A 159
ALA A 228
VAL A 238
 None
 0.93A 3tmzA-4j1lA:
1.5		 3tmzA-4j1lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		3 / 3 HIS A 237
HIS A 240
ILE A 236
 ZN  A 501 (-3.3A)
None
None
 0.86A 3u52A-4j1lA:
undetectable
3u52C-4j1lA:
undetectable		 3u52A-4j1lA:
23.80
3u52C-4j1lA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 11 HIS A 233
GLU A 234
HIS A 237
GLU A 271
TYR A 375
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.1A)
ZN  A 501 (-3.3A)
ZN  A 501 (-1.9A)
None
 0.72A 4c2pA-4j1lA:
2.1		 4c2pA-4j1lA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 PHE A 275
ASP A 279
SER A 377
ARG A 372
 None
 1.17A 4lv9A-4j1lA:
undetectable
4lv9B-4j1lA:
undetectable		 4lv9A-4j1lA:
21.89
4lv9B-4j1lA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 7 PHE A 275
ASP A 279
SER A 377
ARG A 372
 None
 1.18A 4lv9A-4j1lA:
undetectable
4lv9B-4j1lA:
undetectable		 4lv9A-4j1lA:
21.89
4lv9B-4j1lA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 5 GLY A 161
LEU A 157
ILE A  45
LEU A 231
 None
 0.83A 4o8fA-4j1lA:
undetectable		 4o8fA-4j1lA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		5 / 12 HIS A 233
GLU A 234
HIS A 237
GLU A 271
TYR A 375
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.1A)
ZN  A 501 (-3.3A)
ZN  A 501 (-1.9A)
None
 0.54A 4r7lA-4j1lA:
3.2		 4r7lA-4j1lA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 8 TYR A 299
GLY A 189
ILE A 193
GLY A 241
 None
 0.83A 5alcL-4j1lA:
undetectable		 5alcL-4j1lA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		3 / 3 ASN A 138
TYR A  33
CYH A  27
 None
 1.04A 5lsuB-4j1lA:
undetectable		 5lsuB-4j1lA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		4 / 4 HIS A 237
HIS A 233
TYR A 375
GLU A 271
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.5A)
None
ZN  A 501 (-1.9A)
 1.24A 5pahA-4j1lA:
undetectable		 5pahA-4j1lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4j1l TETANUS TOXIN
(Clostridium
tetani) 		3 / 3 ALA A  36
PHE A 160
GLN A 195
 None
 0.81A 6eceA-4j1lA:
undetectable		 6eceA-4j1lA:
19.58