SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 11 PHE A 314
ALA A 341
ALA A 339
VAL A  93
LEU A  95
 None
 1.33A 1hbpA-4j1sA:
undetectable		 1hbpA-4j1sA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 VAL A 243
ILE A 186
LEU A 185
GLY A 269
ALA A 270
 None
 0.94A 1r9oA-4j1sA:
undetectable		 1r9oA-4j1sA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 6 PHE A 314
PHE A 360
ASN A 361
ARG A 345
 None
 1.38A 1t9uA-4j1sA:
undetectable		 1t9uA-4j1sA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 MET A 132
ILE A  92
SER A  43
MET A  45
GLN A  90
 None
 1.17A 1xotB-4j1sA:
undetectable		 1xotB-4j1sA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 LEU A  82
LEU A 119
ILE A  87
ILE A  27
LEU A  74
 None
 0.86A 2bdmA-4j1sA:
undetectable		 2bdmA-4j1sA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 GLY A 188
ARG A 215
ASP A 242
SER A 244
ALA A 270
 None
 0.71A 2br4C-4j1sA:
4.8		 2br4C-4j1sA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 LEU A 193
GLY A 188
ASP A 242
SER A 244
ALA A 270
 None
 1.01A 2br4C-4j1sA:
4.8		 2br4C-4j1sA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		3 / 3 ASP A 306
PHE A 307
LEU A 309
 None
 0.74A 2zi9A-4j1sA:
2.4		 2zi9A-4j1sA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 4 GLY A 182
TYR A 184
GLY A 265
ASP A 310
 None
 1.33A 3kl3A-4j1sA:
undetectable		 3kl3A-4j1sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 6 ARG A 344
THR A 357
ALA A 349
ALA A 348
 None
 0.92A 3ns1C-4j1sA:
undetectable		 3ns1C-4j1sA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 8 ARG A 344
THR A 357
ALA A 349
ALA A 348
 None
 0.92A 3ns1L-4j1sA:
0.6		 3ns1L-4j1sA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 7 SER A 317
GLN A 327
TYR A 330
MET A 370
 None
 0.62A 4hxyB-4j1sA:
36.6		 4hxyB-4j1sA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 5 LEU A   3
GLU A   1
LEU A 416
LYS A 420
 None
 1.26A 4k4yA-4j1sA:
undetectable		 4k4yA-4j1sA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 5 LEU A   3
GLU A   1
LEU A 416
LYS A 420
 None
 1.26A 4k4yI-4j1sA:
undetectable		 4k4yI-4j1sA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 7 GLU A 258
GLU A 255
GLU A 254
ARG A 239
 None
 1.13A 4mi4B-4j1sA:
undetectable
4mi4C-4j1sA:
undetectable		 4mi4B-4j1sA:
18.52
4mi4C-4j1sA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 8 GLU A 258
GLU A 255
GLU A 254
ARG A 239
 None
 1.13A 4mj8B-4j1sA:
undetectable
4mj8C-4j1sA:
undetectable		 4mj8B-4j1sA:
17.72
4mj8C-4j1sA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 5 SER A 216
GLU A 288
SER A 273
GLN A 327
 None
 1.44A 5fhrB-4j1sA:
undetectable		 5fhrB-4j1sA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 ALA A  61
ASP A 338
PHE A 336
GLY A 104
SER A 106
 None
 1.32A 5hfjE-4j1sA:
2.4		 5hfjE-4j1sA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 ALA A 121
LEU A  74
VAL A 105
TYR A  67
PHE A  31
 None
 1.33A 5vlmE-4j1sA:
undetectable		 5vlmE-4j1sA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4j1s POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 GLY A 323
THR A 111
GLY A 107
ASN A 334
PHE A 410
 None
 1.05A 5ybbA-4j1sA:
undetectable		 5ybbA-4j1sA:
23.20