SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 ARG A 572
ALA A 585
GLY A 620
VAL A 653
ILE A 567
 None
 0.92A 2f8gA-4j1yA:
undetectable		 2f8gA-4j1yA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 ALA A 635
GLY A 462
LEU A 464
VAL A 653
GLY A 651
 None
 1.15A 2f8lA-4j1yA:
undetectable		 2f8lA-4j1yA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 ARG A 572
ALA A 585
GLY A 620
VAL A 653
ILE A 567
 None
 0.99A 2hs2B-4j1yA:
undetectable		 2hs2B-4j1yA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 ALA A 619
ALA A 584
GLY A 634
GLY A 630
TYR A 648
 None
 1.15A 2igtA-4j1yA:
undetectable		 2igtA-4j1yA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 ALA A 619
ALA A 584
GLY A 634
GLY A 630
TYR A 648
 None
 1.11A 2igtB-4j1yA:
undetectable		 2igtB-4j1yA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 TYR A 648
PHE A 647
ALA A 619
GLY A 565
TYR A 665
 None
 1.13A 2p16A-4j1yA:
26.3		 2p16A-4j1yA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7I_A_TESA205_1
(ANDROGEN RECEPTOR)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.43A 2q7iA-4j1yA:
undetectable		 2q7iA-4j1yA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.42A 2q7kA-4j1yA:
undetectable		 2q7kA-4j1yA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.42A 2q7lA-4j1yA:
undetectable		 2q7lA-4j1yA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.41A 2yloA-4j1yA:
undetectable		 2yloA-4j1yA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		4 / 8 ILE A 617
SER A 627
ARG A 572
SER A 654
 None
 1.14A 2zw9B-4j1yA:
undetectable		 2zw9B-4j1yA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 ARG A 572
ALA A 585
GLY A 620
VAL A 653
ILE A 567
 None
 0.98A 3d20A-4j1yA:
undetectable		 3d20A-4j1yA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 10 PRO A 373
SER A 380
ILE A 361
PRO A 362
GLY A 360
 None
 1.38A 3iluB-4j1yA:
undetectable
3iluE-4j1yA:
undetectable		 3iluB-4j1yA:
22.42
3iluE-4j1yA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 11 ILE A 361
PRO A 362
GLY A 360
PRO A 373
SER A 380
 None
 1.39A 3iluB-4j1yA:
undetectable
3iluE-4j1yA:
undetectable		 3iluB-4j1yA:
22.42
3iluE-4j1yA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 8 ILE A 361
PRO A 362
GLY A 360
PRO A 373
SER A 380
 None
 1.26A 3lslA-4j1yA:
undetectable
3lslD-4j1yA:
undetectable		 3lslA-4j1yA:
22.42
3lslD-4j1yA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 8 PRO A 373
SER A 380
ILE A 361
PRO A 362
GLY A 360
 None
 1.31A 3lslA-4j1yA:
undetectable
3lslD-4j1yA:
undetectable		 3lslA-4j1yA:
22.42
3lslD-4j1yA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 ARG A 572
ALA A 585
GLY A 620
VAL A 653
ILE A 567
 None
 0.98A 3mwsB-4j1yA:
undetectable		 3mwsB-4j1yA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 TYR A 665
LEU A 587
ARG A 586
GLY A 663
LEU A 566
 None
 1.11A 3okxB-4j1yA:
0.7		 3okxB-4j1yA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 11 ARG A 572
ALA A 585
GLY A 620
VAL A 653
ILE A 567
 None
 1.06A 3oxvD-4j1yA:
undetectable		 3oxvD-4j1yA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 ARG A 572
ALA A 585
GLY A 620
VAL A 653
ILE A 567
 None
 1.02A 3pwmA-4j1yA:
undetectable		 3pwmA-4j1yA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.42A 3zqtA-4j1yA:
undetectable		 3zqtA-4j1yA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		4 / 7 TYR A 468
ILE A 465
ASN A 466
GLU A 506
 None
 1.14A 4a97H-4j1yA:
undetectable		 4a97H-4j1yA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		3 / 3 TYR A 390
MET A 541
ILE A 465
 None
 0.91A 4c8bB-4j1yA:
undetectable		 4c8bB-4j1yA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 10 ARG A 572
ALA A 585
GLY A 620
VAL A 653
ILE A 567
 None
 1.04A 4dqcA-4j1yA:
undetectable		 4dqcA-4j1yA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		6 / 10 VAL A 487
LEU A 464
VAL A 453
LEU A 535
THR A 504
VAL A 470
 None
 1.20A 4e3hA-4j1yA:
undetectable		 4e3hA-4j1yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 10 VAL A 476
ALA A 474
ASP A 529
PHE A 526
ARG A 572
 None
 1.39A 4eilB-4j1yA:
undetectable		 4eilB-4j1yA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 11 VAL A 476
ALA A 474
ASP A 529
PHE A 526
ARG A 572
 None
 1.36A 4eilE-4j1yA:
undetectable		 4eilE-4j1yA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 10 VAL A 476
ALA A 474
ASP A 529
PHE A 526
ARG A 572
 None
 1.39A 4eilG-4j1yA:
undetectable		 4eilG-4j1yA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 10 ARG A 572
ALA A 585
GLY A 620
VAL A 653
ILE A 567
 None
 1.06A 4q1wB-4j1yA:
undetectable		 4q1wB-4j1yA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 VAL A 668
GLY A 462
ILE A 530
LEU A 532
LEU A 464
 None
 1.00A 4qdjA-4j1yA:
undetectable		 4qdjA-4j1yA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 SER A 632
ALA A 473
ASP A 529
PHE A 526
THR A 666
 None
 1.32A 4xt8A-4j1yA:
undetectable		 4xt8A-4j1yA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		4 / 7 ASN A 480
VAL A 477
ALA A 473
GLY A 462
 None
 0.93A 5fpdA-4j1yA:
undetectable		 5fpdA-4j1yA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		4 / 7 ILE A 548
VAL A 492
ILE A 446
PHE A 454
 None
 0.96A 5hieC-4j1yA:
0.4		 5hieC-4j1yA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 11 ILE A 548
ASP A 640
ALA A 649
LEU A 471
VAL A 668
 None
 1.31A 5hw4B-4j1yA:
undetectable		 5hw4B-4j1yA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 ILE A 567
ALA A 585
GLY A 462
GLY A 569
GLY A 651
 None
 1.13A 5i71A-4j1yA:
undetectable		 5i71A-4j1yA:
19.68