SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A28_B_STRB2_1 (PROGESTERONE RECEPTOR)	4j25	PUTATIVE UNCHARACTERIZED PROTEIN (Pseudomonas putida)	5 / 12	LEU A 140 LEU A 142 LEU A 193 LEU A 33 CYH A 83	None	1.29A	1a28B-4j25A: undetectable	1a28B-4j25A: 18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK3_A_T44A3001_1 (SERUM ALBUMIN)	4j25	PUTATIVE UNCHARACTERIZED PROTEIN (Pseudomonas putida)	5 / 11	PRO A 5 LEU A 33 LEU A 37 ARG A 44 ALA A 80	None	1.39A	1hk3A-4j25A: undetectable	1hk3A-4j25A: 16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQN_A_NDRA1001_0 (PROGESTERONE RECEPTOR)	4j25	PUTATIVE UNCHARACTERIZED PROTEIN (Pseudomonas putida)	5 / 12	LEU A 140 LEU A 142 LEU A 193 LEU A 33 CYH A 83	None	1.41A	1sqnA-4j25A: undetectable	1sqnA-4j25A: 19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UOB_A_PNNA1311_0 (DEACETOXYCEPHALOSPOR IN C SYNTHETASE)	4j25	PUTATIVE UNCHARACTERIZED PROTEIN (Pseudomonas putida)	5 / 12	HIS A 124 ASP A 126 HIS A 183 SER A 194 VAL A 139	MN A 401 ( 3.3A) MN A 401 ( 2.6A) MN A 401 ( 3.3A) OGA A 402 ( 3.7A) OGA A 402 ( 4.9A)	1.44A	1uobA-4j25A: 10.3	1uobA-4j25A: 21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UOB_A_PNNA1311_0 (DEACETOXYCEPHALOSPOR IN C SYNTHETASE)	4j25	PUTATIVE UNCHARACTERIZED PROTEIN (Pseudomonas putida)	5 / 12	HIS A 124 ASP A 126 LEU A 154 HIS A 183 SER A 194	MN A 401 ( 3.3A) MN A 401 ( 2.6A) OGA A 402 (-3.7A) MN A 401 ( 3.3A) OGA A 402 ( 3.7A)	0.61A	1uobA-4j25A: 10.3	1uobA-4j25A: 21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UOF_A_PNNA1312_0 (DEACETOXYCEPHALOSPOR IN C SYNTHETASE)	4j25	PUTATIVE UNCHARACTERIZED PROTEIN (Pseudomonas putida)	6 / 11	HIS A 124 ASP A 126 HIS A 183 VAL A 185 SER A 194 VAL A 139	MN A 401 ( 3.3A) MN A 401 ( 2.6A) MN A 401 ( 3.3A) None OGA A 402 ( 3.7A) OGA A 402 ( 4.9A)	1.36A	1uofA-4j25A: 9.4	1uofA-4j25A: 21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W8Y_B_NDRB1000_0 (PROGESTERONE RECEPTOR)	4j25	PUTATIVE UNCHARACTERIZED PROTEIN (Pseudomonas putida)	5 / 12	LEU A 140 LEU A 142 LEU A 193 LEU A 33 CYH A 83	None	1.38A	2w8yB-4j25A: undetectable	2w8yB-4j25A: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AV6_A_SAMA1_0 (DNA (CYTOSINE-5)-METHYLT RANSFERASE 1)	4j25	PUTATIVE UNCHARACTERIZED PROTEIN (Pseudomonas putida)	5 / 12	PHE A 28 GLY A 171 LEU A 33 PRO A 8 ALA A 31	None	0.97A	3av6A-4j25A: undetectable	3av6A-4j25A: 10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D90_A_NOGA1001_1 (PROGESTERONE RECEPTOR)	4j25	PUTATIVE UNCHARACTERIZED PROTEIN (Pseudomonas putida)	5 / 12	LEU A 140 LEU A 142 LEU A 193 LEU A 33 CYH A 83	None	1.42A	3d90A-4j25A: undetectable	3d90A-4j25A: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O0M_A_ACTA146_0 (HIT FAMILY PROTEIN)	4j25	PUTATIVE UNCHARACTERIZED PROTEIN (Pseudomonas putida)	4 / 4	ASP A 107 GLU A 109 GLU A 106 ARG A 133	None	1.03A	3o0mA-4j25A: undetectable	3o0mA-4j25A: 23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ICX_E_SC2E1_1 (CETUXIMAB FAB LIGHT CHAIN MEDITOPE)	4j25	PUTATIVE UNCHARACTERIZED PROTEIN (Pseudomonas putida)	3 / 3	VAL A 166 GLN A 25 CYH A 172	None	0.77A	5icxA-4j25A: undetectable 5icxE-4j25A: undetectable	5icxA-4j25A: 19.83 5icxE-4j25A: 5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ICX_F_SC2F1_1 (CETUXIMAB FAB LIGHT CHAIN MEDITOPE)	4j25	PUTATIVE UNCHARACTERIZED PROTEIN (Pseudomonas putida)	3 / 3	VAL A 166 GLN A 25 CYH A 172	None	0.84A	5icxC-4j25A: undetectable 5icxF-4j25A: undetectable	5icxC-4j25A: 19.83 5icxF-4j25A: 5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JVZ_B_FLPB601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4j25	PUTATIVE UNCHARACTERIZED PROTEIN (Pseudomonas putida)	5 / 12	VAL A 13 LEU A 17 LEU A 10 ALA A 138 LEU A 173	None	1.14A	5jvzB-4j25A: undetectable	5jvzB-4j25A: 15.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A28_B_STRB2_1","PROGESTERONE RECEPTOR","4j25","PUTATIVE UNCHARACTERIZED PROTEIN","Pseudomonas putida",5,"LEU A 140;LEU A 142;LEU A 193;LEU A  33;CYH A  83","None","1.29A","1a28B-4j25A:undetectable","1a28B-4j25A:18.59"],["1HK3_A_T44A3001_1","SERUM ALBUMIN","4j25","PUTATIVE UNCHARACTERIZED PROTEIN","Pseudomonas putida",5,"PRO A   5;LEU A  33;LEU A  37;ARG A  44;ALA A  80","None","1.39A","1hk3A-4j25A:undetectable","1hk3A-4j25A:16.82"],["1SQN_A_NDRA1001_0","PROGESTERONE RECEPTOR","4j25","PUTATIVE UNCHARACTERIZED PROTEIN","Pseudomonas putida",5,"LEU A 140;LEU A 142;LEU A 193;LEU A  33;CYH A  83","None","1.41A","1sqnA-4j25A:undetectable","1sqnA-4j25A:19.13"],["1UOB_A_PNNA1311_0","DEACETOXYCEPHALOSPORIN C SYNTHETASE","4j25","PUTATIVE UNCHARACTERIZED PROTEIN","Pseudomonas putida",5,"HIS A 124;ASP A 126;HIS A 183;SER A 194;VAL A 139"," MN A 401 ( 3.3A); MN A 401 ( 2.6A); MN A 401 ( 3.3A);OGA A 402 ( 3.7A);OGA A 402 ( 4.9A)","1.44A","1uobA-4j25A:10.3","1uobA-4j25A:21.54"],["1UOB_A_PNNA1311_0","DEACETOXYCEPHALOSPORIN C SYNTHETASE","4j25","PUTATIVE UNCHARACTERIZED PROTEIN","Pseudomonas putida",5,"HIS A 124;ASP A 126;LEU A 154;HIS A 183;SER A 194"," MN A 401 ( 3.3A); MN A 401 ( 2.6A);OGA A 402 (-3.7A); MN A 401 ( 3.3A);OGA A 402 ( 3.7A)","0.61A","1uobA-4j25A:10.3","1uobA-4j25A:21.54"],["1UOF_A_PNNA1312_0","DEACETOXYCEPHALOSPORIN C SYNTHETASE","4j25","PUTATIVE UNCHARACTERIZED PROTEIN","Pseudomonas putida",6,"HIS A 124;ASP A 126;HIS A 183;VAL A 185;SER A 194;VAL A 139"," MN A 401 ( 3.3A); MN A 401 ( 2.6A); MN A 401 ( 3.3A);None;OGA A 402 ( 3.7A);OGA A 402 ( 4.9A)","1.36A","1uofA-4j25A:9.4","1uofA-4j25A:21.54"],["2W8Y_B_NDRB1000_0","PROGESTERONE RECEPTOR","4j25","PUTATIVE UNCHARACTERIZED PROTEIN","Pseudomonas putida",5,"LEU A 140;LEU A 142;LEU A 193;LEU A  33;CYH A  83","None","1.38A","2w8yB-4j25A:undetectable","2w8yB-4j25A:19.93"],["3AV6_A_SAMA1_0","DNA (CYTOSINE-5)-METHYLTRANSFERASE 1","4j25","PUTATIVE UNCHARACTERIZED PROTEIN","Pseudomonas putida",5,"PHE A  28;GLY A 171;LEU A  33;PRO A   8;ALA A  31","None","0.97A","3av6A-4j25A:undetectable","3av6A-4j25A:10.88"],["3D90_A_NOGA1001_1","PROGESTERONE RECEPTOR","4j25","PUTATIVE UNCHARACTERIZED PROTEIN","Pseudomonas putida",5,"LEU A 140;LEU A 142;LEU A 193;LEU A  33;CYH A  83","None","1.42A","3d90A-4j25A:undetectable","3d90A-4j25A:19.57"],["3O0M_A_ACTA146_0","HIT FAMILY PROTEIN","4j25","PUTATIVE UNCHARACTERIZED PROTEIN","Pseudomonas putida",4,"ASP A 107;GLU A 109;GLU A 106;ARG A 133","None","1.03A","3o0mA-4j25A:undetectable","3o0mA-4j25A:23.56"],["5ICX_E_SC2E1_1","CETUXIMAB FAB LIGHT CHAIN;MEDITOPE","4j25","PUTATIVE UNCHARACTERIZED PROTEIN","Pseudomonas putida",3,"VAL A 166;GLN A  25;CYH A 172","None","0.77A","5icxA-4j25A:undetectable;5icxE-4j25A:undetectable","5icxA-4j25A:19.83;5icxE-4j25A:5.47"],["5ICX_F_SC2F1_1","CETUXIMAB FAB LIGHT CHAIN;MEDITOPE","4j25","PUTATIVE UNCHARACTERIZED PROTEIN","Pseudomonas putida",3,"VAL A 166;GLN A  25;CYH A 172","None","0.84A","5icxC-4j25A:undetectable;5icxF-4j25A:undetectable","5icxC-4j25A:19.83;5icxF-4j25A:5.47"],["5JVZ_B_FLPB601_1","PROSTAGLANDIN G\/H SYNTHASE 2","4j25","PUTATIVE UNCHARACTERIZED PROTEIN","Pseudomonas putida",5,"VAL A  13;LEU A  17;LEU A  10;ALA A 138;LEU A 173","None","1.14A","5jvzB-4j25A:undetectable","5jvzB-4j25A:15.36"]]