SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4j2g KLTH0A00704P
(Lachancea
thermotolerans) 		4 / 8 LEU A  82
ARG A 205
GLY A 204
PHE A 256
 None
 0.96A 1fapB-4j2gA:
undetectable		 1fapB-4j2gA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4j2g KLTH0A00704P
(Lachancea
thermotolerans) 		4 / 5 SER A 202
LEU A 208
GLY A 207
ARG A 118
 SO4  A 301 ( 4.5A)
SO4  A 301 (-4.0A)
SO4  A 301 (-3.6A)
SO4  A 301 (-2.6A)
 0.87A 2j2pA-4j2gA:
undetectable
2j2pB-4j2gA:
undetectable		 2j2pA-4j2gA:
22.18
2j2pB-4j2gA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 4j2g KLTH0A00704P
(Lachancea
thermotolerans) 		4 / 4 LEU A 225
PRO A 226
LEU A 229
ARG A 118
 None
None
None
SO4  A 301 (-2.6A)
 1.19A 2qd2A-4j2gA:
undetectable		 2qd2A-4j2gA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4j2g KLTH0A00704P
(Lachancea
thermotolerans) 		3 / 3 LEU A 225
PRO A 226
LEU A 229
 None
 0.50A 2qd5B-4j2gA:
undetectable		 2qd5B-4j2gA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4j2g KLTH0A00704P
(Lachancea
thermotolerans) 		4 / 6 LEU A 116
THR A  80
LEU A 165
ASP A 253
 None
 1.09A 2wm3A-4j2gA:
undetectable		 2wm3A-4j2gA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4j2g KLTH0A00704P
(Lachancea
thermotolerans) 		4 / 6 ARG A 232
TYR A 250
PRO A 166
LEU A 164
 None
 1.19A 3tgvB-4j2gA:
undetectable		 3tgvB-4j2gA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 4j2g KLTH0A00704P
(Lachancea
thermotolerans) 		4 / 5 ARG A 232
TYR A 250
PRO A 166
LEU A 164
 None
 1.06A 3tgvC-4j2gA:
undetectable		 3tgvC-4j2gA:
18.66