SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 9 ASN A 185
ILE A 187
PRO A 189
ALA A 247
ILE A 245
 None
 1.47A 1aj6A-4j2hA:
undetectable		 1aj6A-4j2hA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 TYR A 150
LEU A 232
VAL A 142
VAL A 228
HIS A 243
 EDO  A 302 ( 4.2A)
None
None
None
EDO  A 304 ( 3.9A)
 1.18A 1q23H-4j2hA:
undetectable
1q23I-4j2hA:
undetectable		 1q23H-4j2hA:
23.36
1q23I-4j2hA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 GLY A 190
ALA A 247
LEU A 252
PRO A 246
 EDO  A 303 (-3.9A)
None
None
None
 0.93A 3bgdA-4j2hA:
6.7		 3bgdA-4j2hA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 11 ASP A 248
GLY A 249
ASP A 224
ILE A 187
VAL A 228
 None
 0.99A 3ebzB-4j2hA:
undetectable		 3ebzB-4j2hA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 TYR A 159
ILE A 114
SER A 149
SER A 146
 1PE  A 307 (-3.6A)
None
None
EDO  A 303 (-2.7A)
 1.23A 3pmzD-4j2hA:
undetectable		 3pmzD-4j2hA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A 229
ILE A 187
THR A 170
LEU A 166
ILE A 141
 None
 1.21A 3qfxB-4j2hA:
2.5		 3qfxB-4j2hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 TYR A 150
LEU A 232
VAL A 142
VAL A 228
HIS A 243
 EDO  A 302 ( 4.2A)
None
None
None
EDO  A 304 ( 3.9A)
 1.09A 3u9fB-4j2hA:
undetectable
3u9fC-4j2hA:
undetectable		 3u9fB-4j2hA:
23.36
3u9fC-4j2hA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 TYR A 150
LEU A 232
VAL A 142
VAL A 228
HIS A 243
 EDO  A 302 ( 4.2A)
None
None
None
EDO  A 304 ( 3.9A)
 1.15A 3u9fH-4j2hA:
undetectable
3u9fI-4j2hA:
undetectable		 3u9fH-4j2hA:
23.36
3u9fI-4j2hA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 TYR A 150
LEU A 232
VAL A 142
VAL A 228
HIS A 243
 EDO  A 302 ( 4.2A)
None
None
None
EDO  A 304 ( 3.9A)
 1.13A 3u9fJ-4j2hA:
undetectable
3u9fK-4j2hA:
undetectable		 3u9fJ-4j2hA:
23.36
3u9fK-4j2hA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 11 TYR A 150
LEU A 232
VAL A 142
VAL A 228
HIS A 243
 EDO  A 302 ( 4.2A)
None
None
None
EDO  A 304 ( 3.9A)
 1.17A 3u9fN-4j2hA:
undetectable
3u9fO-4j2hA:
undetectable		 3u9fN-4j2hA:
23.36
3u9fO-4j2hA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 HIS A 243
TYR A 150
LEU A 232
VAL A 142
VAL A 228
 EDO  A 304 ( 3.9A)
EDO  A 302 ( 4.2A)
None
None
None
 1.11A 3u9fP-4j2hA:
undetectable
3u9fS-4j2hA:
undetectable		 3u9fP-4j2hA:
23.36
3u9fS-4j2hA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 5 SER A 146
ILE A  22
TYR A 159
GLY A 190
 EDO  A 303 (-2.7A)
None
1PE  A 307 (-3.6A)
EDO  A 303 (-3.9A)
 0.96A 3uboB-4j2hA:
6.7		 3uboB-4j2hA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A 229
ILE A 187
THR A 170
LEU A 166
ILE A 141
 None
 1.07A 4km0B-4j2hA:
2.3		 4km0B-4j2hA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 GLU A  98
ILE A 153
THR A 148
TYR A 201
 1PE  A 307 (-3.8A)
1PE  A 307 ( 4.2A)
EDO  A 303 ( 4.2A)
None
 1.45A 4qwpA-4j2hA:
undetectable		 4qwpA-4j2hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 4 LEU A 167
TYR A 251
PRO A 189
ILE A 187
 None
NA  A 306 (-4.0A)
None
None
 1.27A 5esgA-4j2hA:
undetectable		 5esgA-4j2hA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 4 CYH A 233
LEU A  30
LEU A   8
ALA A  35
 None
 1.13A 5hpuA-4j2hA:
undetectable
5hpuB-4j2hA:
undetectable		 5hpuA-4j2hA:
7.56
5hpuB-4j2hA:
8.33