SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 113
LEU A  26
GLY A 118
PHE A  60
VAL A   4
 None
 1.06A 1fduC-4j2uA:
undetectable		 1fduC-4j2uA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		4 / 7 THR A 110
LEU A  23
GLY A  63
LEU A  26
 None
 0.88A 1gtiD-4j2uA:
undetectable		 1gtiD-4j2uA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 145
ILE A  95
LEU A  38
ILE A  15
ILE A 102
 None
 1.02A 1oipA-4j2uA:
5.0		 1oipA-4j2uA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 156
GLN A 217
LEU A 213
MET A 169
THR A 148
 None
 1.48A 1p93B-4j2uA:
undetectable		 1p93B-4j2uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		4 / 6 ALA A  54
SER A  18
PHE A  60
ILE A  15
 None
 1.01A 1yc2A-4j2uA:
2.1		 1yc2A-4j2uA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		4 / 6 ALA A  54
SER A  18
PHE A  60
ILE A  34
 None
 0.95A 1yc2A-4j2uA:
2.1		 1yc2A-4j2uA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 162
GLY A 170
ASP A 173
ALA A 174
ALA A 180
 None
 1.04A 2br4A-4j2uA:
undetectable		 2br4A-4j2uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 162
GLY A 170
ASP A 173
ALA A 174
ALA A 180
 None
 1.12A 2br4C-4j2uA:
undetectable		 2br4C-4j2uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 162
GLY A 170
ASP A 173
ALA A 174
ALA A 180
 None
 1.05A 2br4E-4j2uA:
undetectable		 2br4E-4j2uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 162
GLY A 170
ASP A 173
ALA A 174
ALA A 180
 None
 1.05A 2br4F-4j2uA:
undetectable		 2br4F-4j2uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		4 / 8 HIS A 206
PRO A 204
SER A 130
ASP A 188
 None
 1.24A 2p02A-4j2uA:
undetectable		 2p02A-4j2uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 THR A 148
GLY A 146
ASN A  92
GLY A 269
LEU A 278
 None
 1.19A 3eeyE-4j2uA:
undetectable		 3eeyE-4j2uA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 PHE A 284
GLY A 290
ASP A  77
ASP A 293
LEU A 295
 None
 1.20A 3iv6B-4j2uA:
undetectable		 3iv6B-4j2uA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		4 / 4 LEU A 117
GLY A 116
GLY A 114
THR A 110
 None
 0.83A 3si7A-4j2uA:
undetectable		 3si7A-4j2uA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 9 GLY A 113
GLY A 114
GLU A 136
PHE A 179
ILE A 132
 None
 1.45A 4fgjA-4j2uA:
undetectable
4fgjB-4j2uA:
1.5		 4fgjA-4j2uA:
19.46
4fgjB-4j2uA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 11 PHE A 179
ILE A 132
GLY A 113
GLY A 114
GLU A 136
 None
 1.48A 4fglA-4j2uA:
undetectable
4fglB-4j2uA:
undetectable		 4fglA-4j2uA:
19.46
4fglB-4j2uA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		4 / 5 GLY A 113
GLY A 112
MET A 134
GLU A  88
 None
 1.30A 4fglC-4j2uA:
undetectable		 4fglC-4j2uA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		4 / 6 GLY A 147
GLY A 146
ASN A  92
ILE A 264
 None
 0.82A 4fglD-4j2uA:
undetectable		 4fglD-4j2uA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 277
ILE A  95
GLU A 281
GLY A 116
GLY A 114
 None
 1.19A 4hfpB-4j2uA:
undetectable		 4hfpB-4j2uA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		4 / 8 HIS A 206
PRO A 204
SER A 130
ASP A 188
 None
 1.09A 4kttA-4j2uA:
undetectable		 4kttA-4j2uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		4 / 8 HIS A 206
PRO A 204
SER A 130
ASP A 188
 None
 1.11A 4kttC-4j2uA:
undetectable		 4kttC-4j2uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 11 GLY A 116
GLY A 112
GLU A  88
TRP A  85
HIS A 120
 None
 1.16A 4l8fD-4j2uA:
undetectable		 4l8fD-4j2uA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		4 / 8 HIS A 206
PRO A 204
SER A 130
ASP A 188
 None
 1.14A 4ndnA-4j2uA:
undetectable		 4ndnA-4j2uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		4 / 7 HIS A 206
PRO A 204
SER A 130
ASP A 188
 None
 1.19A 4ndnC-4j2uA:
undetectable		 4ndnC-4j2uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 GLY A  63
GLY A 114
GLY A 116
LEU A 117
ALA A  22
 None
 0.94A 5c0oF-4j2uA:
undetectable		 5c0oF-4j2uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 105
ILE A 132
GLY A 170
ASP A 173
ARG A 182
 None
 1.12A 5h5fA-4j2uA:
undetectable		 5h5fA-4j2uA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 10 GLY A 113
GLY A 114
GLU A 136
PHE A 179
ILE A 132
 None
 1.46A 5lbtA-4j2uA:
undetectable
5lbtB-4j2uA:
undetectable		 5lbtA-4j2uA:
19.35
5lbtB-4j2uA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 147
GLY A 146
MET A 134
LEU A 162
MET A 169
 None
 1.16A 5uc1A-4j2uA:
undetectable		 5uc1A-4j2uA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 147
GLY A 146
MET A 134
LEU A 162
MET A 169
 None
 1.12A 5uc1B-4j2uA:
undetectable		 5uc1B-4j2uA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4j2u ENOYL-COA HYDRATASE
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 116
GLY A 146
SER A 133
GLY A 113
GLY A 114
 None
 0.90A 5wyqA-4j2uA:
undetectable		 5wyqA-4j2uA:
24.66