SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 216
HIS A 220
HIS A 222
HIS A  86
 None
 0.98A 1ei6D-4j34A:
undetectable		 1ei6D-4j34A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 163
PHE A 352
GLY A 346
LEU A 337
PHE A  21
 None
 1.00A 1z11B-4j34A:
undetectable		 1z11B-4j34A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 232
TYR A 374
GLY A 324
LEU A 193
PHE A 246
 None
 0.99A 2azyA-4j34A:
undetectable		 2azyA-4j34A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 120
ALA A  17
ILE A   7
GLY A  11
PHE A 331
 None
None
None
FAD  A 401 (-3.6A)
None
 1.37A 2b17A-4j34A:
undetectable		 2b17A-4j34A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 282
GLN A 251
LEU A 255
LEU A 266
ASN A 269
 None
 1.27A 2ceoB-4j34A:
undetectable		 2ceoB-4j34A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 196
THR A 242
ILE A 200
PRO A 201
THR A 288
 None
 1.22A 2w3aA-4j34A:
undetectable		 2w3aA-4j34A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A   5
SER A  22
SER A 123
GLY A  14
ALA A  17
 None
 1.18A 2x2iC-4j34A:
undetectable		 2x2iC-4j34A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  16
GLY A  58
ASN A 328
GLN A 325
ILE A  59
 None
None
FAD  A 401 (-3.7A)
FAD  A 401 (-4.4A)
None
 1.32A 2ycjA-4j34A:
undetectable		 2ycjA-4j34A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YME_D_CWBD1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 161
TYR A  31
THR A 174
ILE A 165
ASP A 168
 None
 1.49A 2ymeD-4j34A:
0.0
2ymeE-4j34A:
0.0		 2ymeD-4j34A:
19.55
2ymeE-4j34A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 181
LYS A 308
VAL A 304
 None
 0.87A 3brfA-4j34A:
undetectable		 3brfA-4j34A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  19
ASP A 333
VAL A  13
GLY A  58
ILE A  59
 None
None
FAD  A 401 (-3.7A)
None
None
 1.07A 3el5A-4j34A:
undetectable		 3el5A-4j34A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 8 PHE A 245
SER A 243
LEU A 198
PHE A 270
LEU A 266
 None
 1.40A 3i45A-4j34A:
2.4		 3i45A-4j34A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 166
ALA A 316
ASP A 168
ILE A 310
ALA A 309
 None
 1.00A 3jb1A-4j34A:
undetectable		 3jb1A-4j34A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  86
HIS A 222
MET A  84
 None
 0.84A 3mihA-4j34A:
undetectable		 3mihA-4j34A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A 257
SER A 258
ARG A 261
 None
 0.78A 3phnA-4j34A:
undetectable		 3phnA-4j34A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 315
ASP A 314
GLY A  14
ILE A   7
LEU A 133
 None
FAD  A 401 (-3.0A)
None
None
FAD  A 401 (-4.6A)
 1.21A 3u7sB-4j34A:
undetectable		 3u7sB-4j34A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 315
ASP A 314
GLY A  14
ILE A   7
LEU A 133
 None
FAD  A 401 (-3.0A)
None
None
FAD  A 401 (-4.6A)
 1.13A 3u7sA-4j34A:
undetectable		 3u7sA-4j34A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  19
ALA A  20
LEU A  62
GLY A 330
LEU A 312
 None
 1.05A 4pxmA-4j34A:
undetectable		 4pxmA-4j34A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 286
SER A 243
ILE A 200
LEU A 266
LEU A 231
 None
 1.11A 4xumA-4j34A:
undetectable		 4xumA-4j34A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 123
GLY A   9
ASP A  32
GLY A  14
 None
FAD  A 401 (-3.2A)
FAD  A 401 (-2.8A)
None
 0.88A 5cdnR-4j34A:
undetectable
5cdnS-4j34A:
undetectable		 5cdnR-4j34A:
20.43
5cdnS-4j34A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  19
ALA A  20
LEU A  62
GLY A 330
LEU A 312
 None
 1.01A 5dxgB-4j34A:
undetectable		 5dxgB-4j34A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  19
ALA A  20
LEU A  62
GLY A 330
LEU A 312
 None
 1.10A 5gs4A-4j34A:
undetectable		 5gs4A-4j34A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  19
ALA A  20
LEU A  62
GLY A 330
LEU A 312
 None
 1.13A 5gtrA-4j34A:
undetectable		 5gtrA-4j34A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  34
PRO A  37
ASN A 114
 FAD  A 401 (-4.0A)
None
None
 1.02A 5jwaA-4j34A:
11.9
5jwaH-4j34A:
10.6		 5jwaA-4j34A:
20.71
5jwaH-4j34A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		5 / 10 SER A  64
LEU A 112
LEU A  19
ILE A  54
GLY A  58
 None
 1.24A 6dm0B-4j34A:
3.3
6dm0C-4j34A:
3.3		 6dm0B-4j34A:
17.61
6dm0C-4j34A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 325
GLY A 313
GLY A 330
VAL A  13
 FAD  A 401 (-4.4A)
FAD  A 401 (-3.6A)
None
FAD  A 401 (-3.7A)
 0.92A 6ekzA-4j34A:
undetectable		 6ekzA-4j34A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4j34 KYNURENINE
3-MONOOXYGENASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 231
ASN A  51
LEU A 221
 None
 0.74A 6exiD-4j34A:
2.6		 6exiD-4j34A:
14.20