SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 8 LEU A 260
SER A 223
GLN A 166
THR A 191
 None
 0.89A 1ig3A-4j35A:
undetectable
1ig3B-4j35A:
undetectable		 1ig3A-4j35A:
21.68
1ig3B-4j35A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		3 / 3 ASP A 264
HIS A 204
HIS A  21
 CO  A 402 (-2.7A)
CO  A 401 (-3.2A)
CO  A 402 (-3.3A)
 0.68A 1oe1A-4j35A:
undetectable		 1oe1A-4j35A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		3 / 3 ASP A 264
HIS A 204
HIS A  21
 CO  A 402 (-2.7A)
CO  A 401 (-3.2A)
CO  A 402 (-3.3A)
 0.68A 1oe3A-4j35A:
undetectable		 1oe3A-4j35A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 4 SER A 147
GLY A 100
HIS A  21
ASP A  66
 None
None
CO  A 402 (-3.3A)
None
 1.39A 2oxtC-4j35A:
undetectable		 2oxtC-4j35A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 8 LEU A 247
LEU A 218
PRO A  20
GLY A 203
 None
 0.84A 2po5A-4j35A:
undetectable		 2po5A-4j35A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 7 GLY A 183
ASP A 206
TYR A 213
ARG A 243
 None
 1.17A 3arrA-4j35A:
4.6		 3arrA-4j35A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		3 / 3 ALA A  11
VAL A  10
GLN A  89
 None
 0.59A 3of4B-4j35A:
undetectable		 3of4B-4j35A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 VAL A 128
GLY A 140
GLY A 170
ALA A 162
ALA A 163
 None
 1.00A 3sufB-4j35A:
undetectable		 3sufB-4j35A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		3 / 3 ARG A 243
PRO A 211
PHE A 226
 None
 1.02A 3thrC-4j35A:
1.3		 3thrC-4j35A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 8 HIS A 204
ASP A 206
ALA A 225
ASP A 264
 CO  A 401 (-3.2A)
None
None
CO  A 402 (-2.7A)
 1.02A 4k0bB-4j35A:
undetectable		 4k0bB-4j35A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 8 HIS A 204
ASP A 206
ALA A 225
ASP A 264
 CO  A 401 (-3.2A)
None
None
CO  A 402 (-2.7A)
 1.06A 4l7iB-4j35A:
undetectable		 4l7iB-4j35A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 LEU A 190
LEU A 193
GLY A 194
VAL A 165
MET A 124
 None
 1.28A 4oktA-4j35A:
undetectable		 4oktA-4j35A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 THR A 217
THR A 191
ALA A 195
GLY A 183
THR A 177
 None
 1.21A 4qvnV-4j35A:
undetectable
4qvnb-4j35A:
undetectable		 4qvnV-4j35A:
23.38
4qvnb-4j35A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 THR A 217
THR A 191
ALA A 195
GLY A 183
THR A 177
 None
 1.21A 4qvnH-4j35A:
undetectable
4qvnN-4j35A:
undetectable		 4qvnH-4j35A:
23.38
4qvnN-4j35A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 6 HIS A  21
HIS A  23
HIS A 176
HIS A 204
ASP A 264
 CO  A 402 (-3.3A)
CO  A 402 (-3.2A)
CO  A 401 (-3.2A)
CO  A 401 (-3.2A)
CO  A 402 (-2.7A)
 0.73A 4ubpC-4j35A:
13.6		 4ubpC-4j35A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		3 / 3 GLN A  62
ILE A 296
HIS A 291
 None
 0.68A 5z12B-4j35A:
undetectable		 5z12B-4j35A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 5 THR A  68
HIS A  21
ASP A 264
HIS A 204
 None
CO  A 402 (-3.3A)
CO  A 402 (-2.7A)
CO  A 401 (-3.2A)
 0.99A 6dchA-4j35A:
undetectable		 6dchA-4j35A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 5 THR A 177
ASP A 264
HIS A  21
ARG A 228
 None
CO  A 402 (-2.7A)
CO  A 402 (-3.3A)
None
 1.44A 6dchA-4j35A:
undetectable		 6dchA-4j35A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 5 LEU A 231
THR A 237
THR A 239
GLY A 233
 None
 1.22A 6gtqA-4j35A:
undetectable		 6gtqA-4j35A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 HIS A 204
SER A 146
HIS A  23
ASP A 264
ASP A 227
 CO  A 401 (-3.2A)
None
CO  A 402 (-3.2A)
CO  A 402 (-2.7A)
None
 1.16A 6n91A-4j35A:
15.0		 6n91A-4j35A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 4j35 PHOSPHOTRIESTERASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 HIS A 204
SER A 146
HIS A  23
ASP A 264
ASP A 227
 CO  A 401 (-3.2A)
None
CO  A 402 (-3.2A)
CO  A 402 (-2.7A)
None
 1.16A 6n91B-4j35A:
14.5		 6n91B-4j35A:
14.73