SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		5 / 12 THR A 101
LEU A 166
ILE A 142
PHE A  96
LEU A  63
 None
 1.21A 1wsvA-4j38A:
0.8		 1wsvA-4j38A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		5 / 12 THR A 101
LEU A 166
ILE A 142
PHE A  96
LEU A  63
 None
 1.19A 1wsvB-4j38A:
undetectable		 1wsvB-4j38A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		4 / 8 PHE A  86
MET A 100
THR A 101
LEU A 166
 None
 0.76A 2eijN-4j38A:
undetectable
2eijW-4j38A:
undetectable		 2eijN-4j38A:
13.32
2eijW-4j38A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		4 / 7 PHE A  86
MET A 100
THR A 101
LEU A 166
 None
 0.77A 2eikA-4j38A:
undetectable
2eikJ-4j38A:
undetectable		 2eikA-4j38A:
13.32
2eikJ-4j38A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		4 / 8 PHE A  86
MET A 100
THR A 101
LEU A 166
 None
 0.75A 2eikN-4j38A:
undetectable
2eikW-4j38A:
undetectable		 2eikN-4j38A:
13.32
2eikW-4j38A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		4 / 8 PHE A  86
MET A 100
THR A 101
LEU A 166
 None
 0.74A 2eilN-4j38A:
undetectable
2eilW-4j38A:
undetectable		 2eilN-4j38A:
13.32
2eilW-4j38A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		4 / 8 PHE A  86
MET A 100
THR A 101
LEU A 166
 None
 0.73A 3ablN-4j38A:
undetectable
3ablW-4j38A:
undetectable		 3ablN-4j38A:
13.32
3ablW-4j38A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		4 / 6 ILE A  48
THR A 131
PHE A 106
PHE A  86
 None
 1.29A 3elzB-4j38A:
undetectable		 3elzB-4j38A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		5 / 12 THR A  74
LEU A 166
VAL A  46
PHE A 144
ALA A 160
 None
 1.46A 3u9fG-4j38A:
undetectable
3u9fH-4j38A:
undetectable		 3u9fG-4j38A:
21.76
3u9fH-4j38A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		5 / 12 VAL A  99
LEU A 170
PHE A 144
VAL A  65
LEU A  63
 None
 1.23A 3w68C-4j38A:
undetectable		 3w68C-4j38A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		3 / 3 GLU A 117
GLY A 146
SER A 119
 None
 0.31A 4b53B-4j38A:
undetectable		 4b53B-4j38A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		4 / 7 PHE A  86
MET A 100
THR A 101
LEU A 166
 None
 0.79A 5b1bN-4j38A:
undetectable
5b1bW-4j38A:
undetectable		 5b1bN-4j38A:
13.32
5b1bW-4j38A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		4 / 7 PHE A  86
MET A 100
THR A 101
LEU A 166
 None
 0.81A 5b3sN-4j38A:
undetectable
5b3sW-4j38A:
undetectable		 5b3sN-4j38A:
13.32
5b3sW-4j38A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		4 / 7 PHE A  86
MET A 100
THR A 101
LEU A 166
 None
 0.76A 5iy5N-4j38A:
undetectable
5iy5W-4j38A:
undetectable		 5iy5N-4j38A:
13.32
5iy5W-4j38A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 4j38 OUTER SURFACE
PROTEIN E
(Borreliella
burgdorferi) 		4 / 5 HIS A  81
TYR A 111
GLY A 113
TYR A 159
 None
 1.39A 5yodH-4j38A:
undetectable		 5yodH-4j38A:
22.83