SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		4 / 8 TYR A  85
THR A 228
CYH A 169
LEU A 219
 None
 1.35A 1uw6A-4j3cA:
undetectable
1uw6B-4j3cA:
undetectable		 1uw6A-4j3cA:
19.35
1uw6B-4j3cA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		4 / 8 TYR A  85
THR A 228
CYH A 169
LEU A 219
 None
 1.35A 1uw6D-4j3cA:
undetectable
1uw6E-4j3cA:
undetectable		 1uw6D-4j3cA:
19.35
1uw6E-4j3cA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		4 / 8 TYR A  85
THR A 228
CYH A 169
LEU A 219
 None
 1.35A 1uw6G-4j3cA:
undetectable
1uw6H-4j3cA:
undetectable		 1uw6G-4j3cA:
19.35
1uw6H-4j3cA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		4 / 8 TYR A  85
THR A 228
CYH A 169
LEU A 219
 None
 1.36A 1uw6P-4j3cA:
undetectable
1uw6Q-4j3cA:
undetectable		 1uw6P-4j3cA:
19.35
1uw6Q-4j3cA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		5 / 11 GLY A 195
GLY A 199
LEU A 224
ALA A 226
ALA A 229
 None
 0.43A 1x7pA-4j3cA:
11.5
1x7pB-4j3cA:
10.7		 1x7pA-4j3cA:
28.85
1x7pB-4j3cA:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		5 / 12 GLY A 195
GLY A 199
LEU A 219
LEU A 224
ALA A 229
 None
 0.36A 2egvA-4j3cA:
20.7		 2egvA-4j3cA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		5 / 12 GLY A 195
GLY A 199
LEU A 219
LEU A 224
ALA A 229
 None
 0.36A 2egvB-4j3cA:
20.9		 2egvB-4j3cA:
26.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		6 / 9 GLY A 195
GLY A 199
LEU A 219
ILE A 223
LEU A 224
ALA A 229
 None
 0.72A 2z0yA-4j3cA:
16.5		 2z0yA-4j3cA:
33.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		6 / 9 GLY A 195
GLY A 199
LEU A 219
ILE A 223
LEU A 224
ALA A 229
 None
 0.64A 2z0yB-4j3cA:
16.6		 2z0yB-4j3cA:
33.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		5 / 12 GLY A 108
ASP A  82
ILE A 144
GLY A  49
LEU A 110
 None
 1.16A 3eeyH-4j3cA:
2.4		 3eeyH-4j3cA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		5 / 12 GLY A 108
ASP A  82
ILE A 144
GLY A  49
LEU A 110
 None
 1.15A 3eeyI-4j3cA:
undetectable		 3eeyI-4j3cA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		4 / 7 ARG A 188
GLN A 238
ARG A 245
ILE A 237
 None
 1.05A 3ln1C-4j3cA:
undetectable		 3ln1C-4j3cA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		4 / 7 ILE A 237
THR A 240
VAL A  84
ASP A 163
 None
 1.39A 4iarA-4j3cA:
undetectable		 4iarA-4j3cA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		4 / 6 GLY A 195
PRO A 196
GLU A 204
SER A 201
 None
 0.98A 5ny7A-4j3cA:
undetectable		 5ny7A-4j3cA:
24.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		6 / 9 ILE A 194
GLY A 195
GLY A 199
LEU A 219
LEU A 224
ALA A 229
 None
 0.54A 5o96A-4j3cA:
18.5
5o96B-4j3cA:
18.5		 5o96A-4j3cA:
31.27
5o96B-4j3cA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		5 / 10 ILE A 194
GLY A 195
GLY A 199
LEU A 224
ALA A 229
 None
 0.54A 5o96C-4j3cA:
17.4
5o96D-4j3cA:
23.0		 5o96C-4j3cA:
31.27
5o96D-4j3cA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		5 / 10 GLY A 195
GLY A 199
LEU A 224
ARG A 225
ALA A 229
 None
 0.91A 5o96E-4j3cA:
23.2
5o96F-4j3cA:
22.9		 5o96E-4j3cA:
31.27
5o96F-4j3cA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		5 / 11 GLY A 195
GLU A 197
GLY A 199
LEU A 219
ALA A 229
 None
 0.76A 5o96G-4j3cA:
18.0		 5o96G-4j3cA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		5 / 11 GLY A 195
GLY A 199
LEU A 219
ARG A 225
ALA A 229
 None
 0.99A 5o96G-4j3cA:
18.0		 5o96G-4j3cA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		5 / 10 GLY A 195
GLY A 199
LEU A 219
LEU A 224
ALA A 229
 None
 0.53A 5o96G-4j3cA:
18.0
5o96H-4j3cA:
18.6		 5o96G-4j3cA:
31.27
5o96H-4j3cA:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		4 / 6 GLU A 154
ALA A 203
LEU A 207
SER A 201
 None
 1.13A 5phhA-4j3cA:
undetectable		 5phhA-4j3cA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		5 / 12 ILE A 194
GLY A 195
GLY A 199
LEU A 219
LEU A 224
 None
 0.60A 5twjA-4j3cA:
7.9		 5twjA-4j3cA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		5 / 10 ILE A 194
GLY A 195
GLY A 199
LEU A 219
LEU A 224
 None
 0.56A 5twjB-4j3cA:
8.0		 5twjB-4j3cA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Sinorhizobium
meliloti) 		3 / 3 GLU A 204
LEU A 208
ARG A 209
 None
 0.82A 6d8fA-4j3cA:
undetectable		 6d8fA-4j3cA:
15.99