SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		5 / 11 ASN D 385
PHE D 252
LEU D 322
TYR D 366
ARG D 330
 None
 1.47A 1l5rA-4j3oD:
undetectable		 1l5rA-4j3oD:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		4 / 6 GLY D 633
GLN D 667
ALA D 635
SER D 653
 None
 1.03A 1p6kA-4j3oD:
undetectable		 1p6kA-4j3oD:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		4 / 8 SER D 319
GLN D 324
PHE D 252
ASN D 419
 None
 1.33A 1rs7B-4j3oD:
undetectable		 1rs7B-4j3oD:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		3 / 3 ARG D 697
TYR D 699
LYS D 677
 None
 1.06A 1uujB-4j3oD:
undetectable		 1uujB-4j3oD:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		5 / 11 SER D 653
LEU D 626
ILE D 637
SER D 603
LEU D 602
 None
 0.84A 2qmmA-4j3oD:
undetectable
2qmmB-4j3oD:
undetectable		 2qmmA-4j3oD:
12.35
2qmmB-4j3oD:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		4 / 7 LEU D 417
SER D 393
TYR D 366
VAL D 320
 None
 0.96A 2uz2A-4j3oD:
4.6		 2uz2A-4j3oD:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		4 / 8 TYR D 418
ASN D 419
LYS D 420
PRO D 254
 None
 1.41A 3bjwD-4j3oD:
undetectable		 3bjwD-4j3oD:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		4 / 8 VAL D 280
ILE D 256
VAL D 301
GLN D 311
 None
 0.71A 3fi0B-4j3oD:
undetectable		 3fi0B-4j3oD:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		4 / 7 VAL D 280
ILE D 256
VAL D 301
GLN D 311
 None
 0.70A 3fi0E-4j3oD:
undetectable		 3fi0E-4j3oD:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		4 / 8 VAL D 280
ILE D 256
VAL D 301
GLN D 311
 None
 0.76A 3fi0G-4j3oD:
undetectable		 3fi0G-4j3oD:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		4 / 4 GLY D 367
TYR D 366
GLY D 381
ASP D 395
 None
 0.99A 3kl3A-4j3oD:
undetectable		 3kl3A-4j3oD:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		5 / 12 PRO D  62
THR D  65
LEU D  64
GLN D  68
LEU D  39
 None
 1.41A 4ac0A-4j3oD:
undetectable		 4ac0A-4j3oD:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		4 / 5 VAL D  35
ILE D 115
TYR D  43
MET D  44
 None
 0.93A 4c8bA-4j3oD:
undetectable		 4c8bA-4j3oD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		3 / 3 TYR D  43
MET D  44
ILE D 115
 None
 0.75A 4c8bB-4j3oD:
undetectable		 4c8bB-4j3oD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		4 / 6 ASN D 379
ARG D 415
TYR D 366
LEU D 356
 None
 1.40A 4f8yA-4j3oD:
undetectable
4f8yB-4j3oD:
undetectable		 4f8yA-4j3oD:
11.63
4f8yB-4j3oD:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		4 / 7 LEU D 551
LEU D 532
THR D 523
SER D 496
 None
 0.60A 4iklA-4j3oD:
4.6
4iklB-4j3oD:
undetectable		 4iklA-4j3oD:
10.44
4iklB-4j3oD:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		3 / 3 ARG D 712
GLU D 687
ASN D 688
 None
 0.85A 4imaD-4j3oD:
undetectable		 4imaD-4j3oD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		3 / 3 ARG D 712
GLU D 687
ASN D 688
 None
 0.89A 4ip7D-4j3oD:
undetectable		 4ip7D-4j3oD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		5 / 12 VAL D 733
PHE D 745
LEU D 715
VAL D 674
LEU D 702
 None
 1.10A 4po0A-4j3oD:
undetectable		 4po0A-4j3oD:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		3 / 3 GLU D 131
TRP D 133
ASN D 122
 None
 1.13A 5dv4A-4j3oD:
undetectable		 5dv4A-4j3oD:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		4 / 8 ASP D 695
THR D 694
TYR D 699
THR D 664
 None
 0.94A 5ov9B-4j3oD:
undetectable		 5ov9B-4j3oD:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		5 / 12 GLY D 779
SER D 790
LEU D 789
VAL D 787
LEU D 753
 None
 1.24A 5ubbA-4j3oD:
undetectable		 5ubbA-4j3oD:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		5 / 12 VAL D 733
LEU D 675
ALA D 743
ARG D 693
LEU D 715
 None
 1.06A 6b0iB-4j3oD:
undetectable		 6b0iB-4j3oD:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		4 / 7 ASN D 670
GLY D 691
VAL D 676
LEU D 702
 None
 0.71A 6dwnB-4j3oD:
undetectable		 6dwnB-4j3oD:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4j3o OUTER MEMBRANE USHER
PROTEIN FIMD
(Escherichia
coli) 		5 / 9 ILE D 137
ALA D 139
GLY D 140
GLY D 655
ARG D 742
 None
 1.27A 6nm4B-4j3oD:
undetectable		 6nm4B-4j3oD:
13.23