SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j3q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 12 ASP A 305
GLY A 287
VAL A 157
LEU A 310
MET A 237
 None
 1.41A 1e3vA-4j3qA:
undetectable		 1e3vA-4j3qA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EVE_A_E20A2001_1
(ACETYLCHOLINESTERASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 GLY A 304
TYR A  95
LEU A 130
PHE A 122
HIS A 102
 None
None
None
None
CU  A1001 (-3.2A)
 1.49A 1eveA-4j3qA:
undetectable		 1eveA-4j3qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 12 PHE A 126
THR A 114
ILE A 365
GLN A 105
ALA A 360
 None
 1.45A 1fm4A-4j3qA:
undetectable		 1fm4A-4j3qA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 4 VAL A 157
TRP A 309
TRP A 143
 None
 1.41A 1gmkC-4j3qA:
undetectable
1gmkD-4j3qA:
undetectable		 1gmkC-4j3qA:
4.87
1gmkD-4j3qA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 LEU A 351
ILE A 109
THR A 114
GLN A 105
 None
 1.20A 1kglA-4j3qA:
undetectable		 1kglA-4j3qA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 12 GLY A 287
GLY A 285
GLY A 282
GLY A 146
ASN A 151
 None
 0.88A 1n2xB-4j3qA:
undetectable		 1n2xB-4j3qA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 ARG A 239
TRP A  58
TRP A 143
PHE A 158
 None
 1.32A 1om5A-4j3qA:
undetectable
1om5B-4j3qA:
undetectable		 1om5A-4j3qA:
20.32
1om5B-4j3qA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.28A 1rs6A-4j3qA:
undetectable
1rs6B-4j3qA:
undetectable		 1rs6A-4j3qA:
20.32
1rs6B-4j3qA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 ASP A 139
PHE A  61
ARG A  56
 None
 0.86A 2a3aA-4j3qA:
undetectable		 2a3aA-4j3qA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 ARG A 239
TRP A  58
TRP A 143
PHE A 158
 None
 1.33A 2g6hA-4j3qA:
undetectable
2g6hB-4j3qA:
undetectable		 2g6hA-4j3qA:
20.14
2g6hB-4j3qA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 THR A  93
TYR A  69
PHE A 204
LEU A 130
 None
 1.17A 2hzqA-4j3qA:
undetectable		 2hzqA-4j3qA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 SER A  62
ASP A 139
ASP A  68
 None
 0.81A 2plwA-4j3qA:
undetectable		 2plwA-4j3qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 4 HIS A 119
HIS A 284
HIS A 312
HIS A 110
 CU  A1001 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
 1.11A 2wkoA-4j3qA:
undetectable		 2wkoA-4j3qA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 6 SER A  81
ARG A  92
PRO A  89
GLY A  90
 None
 1.03A 2y7pA-4j3qA:
undetectable		 2y7pA-4j3qA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.60A 2zweA-4j3qA:
27.5
2zweB-4j3qA:
undetectable		 2zweA-4j3qA:
27.42
2zweB-4j3qA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 102
HIS A 288
HIS A 284
ASP A 316
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.47A 2zweA-4j3qA:
27.5
2zweB-4j3qA:
undetectable		 2zweA-4j3qA:
27.42
2zweB-4j3qA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 119
HIS A 288
HIS A 284
VAL A 283
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.43A 2zweA-4j3qA:
27.5
2zweB-4j3qA:
undetectable		 2zweA-4j3qA:
27.42
2zweB-4j3qA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.29A 2zweA-4j3qA:
27.5
2zweB-4j3qA:
undetectable		 2zweA-4j3qA:
27.42
2zweB-4j3qA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 312
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.49A 2zweA-4j3qA:
27.5
2zweB-4j3qA:
undetectable		 2zweA-4j3qA:
27.42
2zweB-4j3qA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.63A 2zwfA-4j3qA:
27.5
2zwfB-4j3qA:
undetectable		 2zwfA-4j3qA:
27.42
2zwfB-4j3qA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 102
HIS A 288
HIS A 284
ASP A 316
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.44A 2zwfA-4j3qA:
27.5
2zwfB-4j3qA:
undetectable		 2zwfA-4j3qA:
27.42
2zwfB-4j3qA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 119
HIS A 288
HIS A 284
VAL A 283
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.49A 2zwfA-4j3qA:
27.5
2zwfB-4j3qA:
undetectable		 2zwfA-4j3qA:
27.42
2zwfB-4j3qA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.24A 2zwfA-4j3qA:
27.5
2zwfB-4j3qA:
undetectable		 2zwfA-4j3qA:
27.42
2zwfB-4j3qA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.63A 2zwgA-4j3qA:
27.6
2zwgB-4j3qA:
undetectable		 2zwgA-4j3qA:
27.42
2zwgB-4j3qA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 119
HIS A 288
HIS A 284
VAL A 283
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.49A 2zwgA-4j3qA:
27.6
2zwgB-4j3qA:
undetectable		 2zwgA-4j3qA:
27.42
2zwgB-4j3qA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.21A 2zwgA-4j3qA:
27.6
2zwgB-4j3qA:
undetectable		 2zwgA-4j3qA:
27.42
2zwgB-4j3qA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 GLN A 273
HIS A 284
HIS A 312
HIS A 288
PHE A 340
 None
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.50A 3dcsA-4j3qA:
undetectable		 3dcsA-4j3qA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.34A 3e7gC-4j3qA:
0.5
3e7gD-4j3qA:
0.6		 3e7gC-4j3qA:
22.43
3e7gD-4j3qA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_D_H4BD4902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.35A 3ej8C-4j3qA:
0.0
3ej8D-4j3qA:
0.6		 3ej8C-4j3qA:
22.20
3ej8D-4j3qA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 311
HIS A 110
HIS A 119
HIS A 102
 None
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 (-3.2A)
 1.07A 3likA-4j3qA:
undetectable		 3likA-4j3qA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 ILE A 109
HIS A 284
HIS A 288
HIS A 312
 None
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
 1.01A 3ljgA-4j3qA:
undetectable		 3ljgA-4j3qA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 HIS A 110
HIS A 119
HIS A 102
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 (-3.2A)
 0.39A 3qpkA-4j3qA:
undetectable		 3qpkA-4j3qA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 HIS A 110
HIS A 119
HIS A 102
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 (-3.2A)
 0.38A 3qpkB-4j3qA:
undetectable		 3qpkB-4j3qA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 THR A 231
GLY A  90
GLY A 212
PRO A 213
ASP A  96
 None
 1.31A 3t8nD-4j3qA:
undetectable
3t8nF-4j3qA:
undetectable		 3t8nD-4j3qA:
18.28
3t8nF-4j3qA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 ARG A 239
TRP A  58
TRP A 143
PHE A 158
 None
 1.37A 4cwyA-4j3qA:
undetectable
4cwyB-4j3qA:
undetectable		 4cwyA-4j3qA:
21.69
4cwyB-4j3qA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 12 GLN A 175
GLY A 292
ILE A 245
LYS A 238
PRO A 219
 None
 0.90A 4gc9A-4j3qA:
undetectable		 4gc9A-4j3qA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 LEU A 190
LEU A 180
LEU A 182
ILE A 245
HIS A 284
 None
None
None
None
CU  A1002 (-3.2A)
 1.31A 4mk4A-4j3qA:
undetectable		 4mk4A-4j3qA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 102
HIS A 110
HIS A 284
HIS A 288
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
 0.41A 4p6sA-4j3qA:
29.0		 4p6sA-4j3qA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 110
HIS A 284
HIS A 288
VAL A 299
 CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 0.79A 4p6sA-4j3qA:
29.0		 4p6sA-4j3qA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 102
HIS A 110
HIS A 284
HIS A 288
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
 0.47A 4p6sB-4j3qA:
29.0		 4p6sB-4j3qA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 110
HIS A 284
HIS A 288
VAL A 299
 CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 0.80A 4p6sB-4j3qA:
29.0		 4p6sB-4j3qA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 LEU A 258
MET A 314
TYR A 249
 None
 0.93A 4p6xG-4j3qA:
undetectable		 4p6xG-4j3qA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.26A 4uchA-4j3qA:
0.4
4uchB-4j3qA:
undetectable		 4uchA-4j3qA:
21.03
4uchB-4j3qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.36A 4v3wA-4j3qA:
undetectable
4v3wB-4j3qA:
undetectable		 4v3wA-4j3qA:
20.32
4v3wB-4j3qA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 9 HIS A 284
TYR A 249
GLY A 286
GLY A 287
HIS A 311
 CU  A1002 (-3.2A)
None
None
None
None
 1.48A 5f8yA-4j3qA:
undetectable		 5f8yA-4j3qA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 9 HIS A 284
TYR A 249
GLY A 286
GLY A 287
HIS A 311
 CU  A1002 (-3.2A)
None
None
None
None
 1.46A 5f8yB-4j3qA:
undetectable		 5f8yB-4j3qA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 7 HIS A 102
HIS A 110
HIS A 284
HIS A 288
VAL A 299
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 0.79A 5i3aA-4j3qA:
28.6		 5i3aA-4j3qA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 7 HIS A 102
HIS A 110
HIS A 284
HIS A 288
VAL A 299
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 0.74A 5i3aB-4j3qA:
28.9		 5i3aB-4j3qA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 102
HIS A 110
HIS A 284
HIS A 288
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
 0.40A 5i3bA-4j3qA:
28.8		 5i3bA-4j3qA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 110
HIS A 284
HIS A 288
VAL A 299
 CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 0.77A 5i3bA-4j3qA:
28.8		 5i3bA-4j3qA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.43A 5m8nA-4j3qA:
26.8		 5m8nA-4j3qA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 HIS A 102
TYR A 111
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
None
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 1.24A 5m8nA-4j3qA:
26.8		 5m8nA-4j3qA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 HIS A 288
HIS A 312
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.42A 5m8nA-4j3qA:
26.8		 5m8nA-4j3qA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.48A 5m8nB-4j3qA:
26.8		 5m8nB-4j3qA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 HIS A 102
TYR A 111
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
None
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 1.29A 5m8nB-4j3qA:
26.8		 5m8nB-4j3qA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 9 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.44A 5m8nC-4j3qA:
26.7		 5m8nC-4j3qA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 9 HIS A 102
TYR A 111
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
None
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 1.25A 5m8nC-4j3qA:
26.7		 5m8nC-4j3qA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 9 HIS A 288
HIS A 312
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.40A 5m8nC-4j3qA:
26.7		 5m8nC-4j3qA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 7 HIS A 110
HIS A 284
HIS A 288
VAL A 299
SER A 302
 CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
CU  A1001 ( 4.9A)
 0.76A 5m8rA-4j3qA:
15.9		 5m8rA-4j3qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 7 HIS A 110
HIS A 312
HIS A 288
VAL A 299
SER A 302
 CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
CU  A1001 ( 4.9A)
 1.32A 5m8rA-4j3qA:
15.9		 5m8rA-4j3qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 8 HIS A 110
HIS A 284
HIS A 288
VAL A 299
SER A 302
 CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
CU  A1001 ( 4.9A)
 0.76A 5m8rB-4j3qA:
26.8		 5m8rB-4j3qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 8 HIS A 110
HIS A 312
HIS A 288
VAL A 299
SER A 302
 CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
CU  A1001 ( 4.9A)
 1.35A 5m8rB-4j3qA:
26.8		 5m8rB-4j3qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 HIS A 288
HIS A 110
HIS A 119
LEU A 116
 CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
None
 0.96A 5m8rB-4j3qA:
26.8		 5m8rB-4j3qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 8 HIS A 110
HIS A 284
HIS A 288
VAL A 299
SER A 302
 CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
CU  A1001 ( 4.9A)
 0.79A 5m8rC-4j3qA:
26.8		 5m8rC-4j3qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 8 HIS A 110
HIS A 284
HIS A 288
VAL A 299
SER A 302
 CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
CU  A1001 ( 4.9A)
 0.79A 5m8rD-4j3qA:
26.8		 5m8rD-4j3qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 HIS A 110
HIS A 312
VAL A 299
SER A 302
 CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
None
CU  A1001 ( 4.9A)
 0.97A 5m8rD-4j3qA:
26.8		 5m8rD-4j3qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 HIS A 288
HIS A 110
HIS A 119
LEU A 116
 CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
None
 0.96A 5m8rD-4j3qA:
26.8		 5m8rD-4j3qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 HIS A 110
HIS A 119
HIS A 102
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 (-3.2A)
 0.39A 5migA-4j3qA:
undetectable		 5migA-4j3qA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 PHE A 308
GLY A 304
GLY A 296
HIS A 288
 CU  A1002 ( 4.9A)
None
None
CU  A1002 (-3.2A)
 0.96A 5n9xA-4j3qA:
undetectable		 5n9xA-4j3qA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.28A 5uo9C-4j3qA:
undetectable
5uo9D-4j3qA:
undetectable		 5uo9C-4j3qA:
21.05
5uo9D-4j3qA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 ARG A 239
TRP A  58
TRP A 143
PHE A 158
 None
 1.35A 5vv9A-4j3qA:
undetectable
5vv9B-4j3qA:
undetectable		 5vv9A-4j3qA:
21.69
5vv9B-4j3qA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 ARG A 239
TRP A  58
TRP A 143
PHE A 158
 None
 1.41A 5vvaA-4j3qA:
undetectable
5vvaB-4j3qA:
undetectable		 5vvaA-4j3qA:
21.69
5vvaB-4j3qA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.66A 5z0fA-4j3qA:
27.6
5z0fB-4j3qA:
undetectable		 5z0fA-4j3qA:
27.69
5z0fB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.26A 5z0fA-4j3qA:
27.6
5z0fB-4j3qA:
undetectable		 5z0fA-4j3qA:
27.69
5z0fB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.62A 5z0gA-4j3qA:
27.6
5z0gB-4j3qA:
undetectable		 5z0gA-4j3qA:
27.69
5z0gB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.28A 5z0gA-4j3qA:
27.6
5z0gB-4j3qA:
undetectable		 5z0gA-4j3qA:
27.69
5z0gB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.63A 5z0hA-4j3qA:
27.7
5z0hB-4j3qA:
undetectable		 5z0hA-4j3qA:
27.69
5z0hB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.24A 5z0hA-4j3qA:
27.7
5z0hB-4j3qA:
undetectable		 5z0hA-4j3qA:
27.69
5z0hB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.64A 5z0iA-4j3qA:
27.7
5z0iB-4j3qA:
undetectable		 5z0iA-4j3qA:
27.69
5z0iB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.25A 5z0iA-4j3qA:
27.7
5z0iB-4j3qA:
undetectable		 5z0iA-4j3qA:
27.69
5z0iB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.62A 5z0jA-4j3qA:
27.6
5z0jB-4j3qA:
undetectable		 5z0jA-4j3qA:
27.69
5z0jB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 102
HIS A 288
HIS A 284
ASP A 316
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.46A 5z0jA-4j3qA:
27.6
5z0jB-4j3qA:
undetectable		 5z0jA-4j3qA:
27.69
5z0jB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 119
HIS A 288
HIS A 284
VAL A 283
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.47A 5z0jA-4j3qA:
27.6
5z0jB-4j3qA:
undetectable		 5z0jA-4j3qA:
27.69
5z0jB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.27A 5z0jA-4j3qA:
27.6
5z0jB-4j3qA:
undetectable		 5z0jA-4j3qA:
27.69
5z0jB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.61A 5z0kA-4j3qA:
27.6
5z0kB-4j3qA:
undetectable		 5z0kA-4j3qA:
27.69
5z0kB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 312
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 1.44A 5z0kA-4j3qA:
27.6
5z0kB-4j3qA:
undetectable		 5z0kA-4j3qA:
27.69
5z0kB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 102
HIS A 288
HIS A 284
ASP A 316
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.44A 5z0kA-4j3qA:
27.6
5z0kB-4j3qA:
undetectable		 5z0kA-4j3qA:
27.69
5z0kB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 119
HIS A 288
HIS A 284
VAL A 283
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.46A 5z0kA-4j3qA:
27.6
5z0kB-4j3qA:
undetectable		 5z0kA-4j3qA:
27.69
5z0kB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.28A 5z0kA-4j3qA:
27.6
5z0kB-4j3qA:
undetectable		 5z0kA-4j3qA:
27.69
5z0kB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.65A 5z0lA-4j3qA:
27.6
5z0lB-4j3qA:
undetectable		 5z0lA-4j3qA:
27.69
5z0lB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 119
HIS A 288
HIS A 284
VAL A 283
 CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.50A 5z0lA-4j3qA:
27.6
5z0lB-4j3qA:
undetectable		 5z0lA-4j3qA:
27.69
5z0lB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.25A 5z0lA-4j3qA:
27.6
5z0lB-4j3qA:
undetectable		 5z0lA-4j3qA:
27.69
5z0lB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 0.66A 5z0mA-4j3qA:
27.6
5z0mB-4j3qA:
undetectable		 5z0mA-4j3qA:
26.92
5z0mB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 119
HIS A 284
HIS A 288
SER A 302
 CU  A1001 (-3.2A)
CU  A1001 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 ( 4.9A)
 1.47A 5z0mA-4j3qA:
27.6
5z0mB-4j3qA:
undetectable		 5z0mA-4j3qA:
26.92
5z0mB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1001 ( 4.9A)
 1.17A 5z0mA-4j3qA:
27.6
5z0mB-4j3qA:
undetectable		 5z0mA-4j3qA:
26.92
5z0mB-4j3qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 HIS A 284
HIS A 288
HIS A 312
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
 0.24A 5zrdA-4j3qA:
3.1		 5zrdA-4j3qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 5 HIS A 284
HIS A 288
PHE A 308
HIS A 311
HIS A 312
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 ( 4.9A)
None
CU  A1002 (-3.2A)
 0.36A 5zrdB-4j3qA:
3.9		 5zrdB-4j3qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 102
HIS A 110
HIS A 119
PHE A 308
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 ( 4.9A)
 0.44A 5zrdB-4j3qA:
3.9		 5zrdB-4j3qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 284
HIS A 288
HIS A 312
PHE A 115
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.06A 5zrdB-4j3qA:
3.9		 5zrdB-4j3qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 4 HIS A 284
HIS A 288
HIS A 311
HIS A 312
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
CU  A1002 (-3.2A)
 0.38A 5zrdC-4j3qA:
3.6		 5zrdC-4j3qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 102
HIS A 110
HIS A 119
PHE A 308
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 ( 4.9A)
 0.49A 5zrdC-4j3qA:
3.6		 5zrdC-4j3qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 284
HIS A 288
HIS A 312
PHE A 115
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.10A 5zrdC-4j3qA:
3.6		 5zrdC-4j3qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 102
HIS A 110
HIS A 119
PHE A 308
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 ( 4.9A)
 0.46A 5zrdD-4j3qA:
18.3		 5zrdD-4j3qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 4 HIS A 284
HIS A 288
HIS A 311
HIS A 312
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
CU  A1002 (-3.2A)
 0.41A 5zrdD-4j3qA:
18.2		 5zrdD-4j3qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 ARG A 239
TRP A  58
TRP A 143
PHE A 158
 None
 1.32A 6auuA-4j3qA:
undetectable
6auuB-4j3qA:
undetectable		 6auuA-4j3qA:
12.81
6auuB-4j3qA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.33A 6av6A-4j3qA:
undetectable
6av6B-4j3qA:
undetectable		 6av6A-4j3qA:
12.50
6av6B-4j3qA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4j3q CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.36A 6cieA-4j3qA:
undetectable
6cieB-4j3qA:
undetectable		 6cieA-4j3qA:
12.50
6cieB-4j3qA:
12.50