SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		5 / 12 ILE A 290
GLY A  39
GLY A  97
SER A  96
VAL A 346
 None
 1.07A 1i9gA-4j3zA:
undetectable		 1i9gA-4j3zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		3 / 3 ALA A 358
VAL A 352
TRP A 318
 None
 0.89A 1kqeB-4j3zA:
undetectable
1kqeD-4j3zA:
undetectable		 1kqeB-4j3zA:
2.42
1kqeD-4j3zA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		3 / 3 TRP A 318
ALA A 358
VAL A 352
 None
 0.87A 1kqeA-4j3zA:
undetectable
1kqeE-4j3zA:
undetectable		 1kqeA-4j3zA:
2.42
1kqeE-4j3zA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		6 / 12 PHE A 341
GLY A  21
GLY A  18
ILE A 337
GLU A 387
ALA A  13
 None
 1.47A 1nv8B-4j3zA:
undetectable		 1nv8B-4j3zA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		4 / 6 PRO A 360
HIS A 323
LEU A  38
ILE A 367
 None
 1.13A 1sbrA-4j3zA:
undetectable
1sbrB-4j3zA:
undetectable		 1sbrA-4j3zA:
18.44
1sbrB-4j3zA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		6 / 12 PHE A 341
GLY A  21
GLY A  18
ILE A 337
GLU A 387
ALA A  13
 None
 1.46A 1sg9B-4j3zA:
undetectable		 1sg9B-4j3zA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		6 / 12 PHE A 341
GLY A  21
GLY A  18
ILE A 337
GLU A 387
ALA A  13
 None
 1.46A 1vq1B-4j3zA:
undetectable		 1vq1B-4j3zA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		3 / 3 TRP A 318
THR A 130
TYR A 162
 None
 0.97A 2a3aA-4j3zA:
7.1		 2a3aA-4j3zA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		3 / 3 TRP A 318
THR A 130
TYR A 162
 None
 0.97A 2a3aB-4j3zA:
6.5		 2a3aB-4j3zA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		4 / 8 ALA A 258
ALA A 308
GLU A 335
LEU A 263
 None
 0.71A 2bxgA-4j3zA:
undetectable		 2bxgA-4j3zA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		5 / 12 ASP A 104
LEU A  38
GLY A  37
VAL A 316
ALA A 319
 None
 1.14A 2kceB-4j3zA:
undetectable		 2kceB-4j3zA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		5 / 12 PHE A 143
GLU A 135
LEU A 132
ARG A 157
GLU A 160
 None
 1.46A 3apxA-4j3zA:
undetectable		 3apxA-4j3zA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		5 / 12 GLY A  93
GLY A 285
PHE A  95
VAL A  58
HIS A  62
 None
 1.30A 3dlcA-4j3zA:
undetectable		 3dlcA-4j3zA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		4 / 8 GLU A 235
TYR A 173
GLU A 261
ILE A 226
 None
 0.79A 3jz0B-4j3zA:
undetectable		 3jz0B-4j3zA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		5 / 9 ASP A 104
ILE A 105
GLY A  37
THR A  31
GLY A  34
 None
 1.25A 4acaB-4j3zA:
undetectable
4acaC-4j3zA:
2.4		 4acaB-4j3zA:
18.25
4acaC-4j3zA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		5 / 12 ASP A 104
LEU A  38
GLY A  37
VAL A 316
ALA A 319
 None
 1.21A 4foxD-4j3zA:
undetectable		 4foxD-4j3zA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		5 / 12 ASP A 104
LEU A  38
GLY A  37
VAL A 316
ALA A 319
 None
 1.25A 4fqsA-4j3zA:
undetectable		 4fqsA-4j3zA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		5 / 12 ASP A 104
LEU A  38
GLY A  37
VAL A 316
ALA A 319
 None
 1.25A 4fqsB-4j3zA:
undetectable		 4fqsB-4j3zA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		5 / 12 ALA A 320
GLY A 285
GLY A 289
ILE A  55
THR A  52
 None
 1.12A 4n48B-4j3zA:
undetectable		 4n48B-4j3zA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		5 / 12 GLY A 209
ALA A 170
ALA A 190
LEU A 232
ALA A 258
 None
 0.88A 5bw4B-4j3zA:
undetectable		 5bw4B-4j3zA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		3 / 3 GLU A 335
HIS A 310
ASP A 168
 None
 0.84A 5c0oG-4j3zA:
undetectable		 5c0oG-4j3zA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		4 / 5 THR A 210
GLU A 335
HIS A 310
ASP A 168
 None
 1.21A 5c0oH-4j3zA:
2.1		 5c0oH-4j3zA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		4 / 6 GLU A 261
ARG A 262
LEU A 263
ARG A 286
 None
 1.27A 5l6eA-4j3zA:
undetectable
5l6eB-4j3zA:
undetectable		 5l6eA-4j3zA:
19.45
5l6eB-4j3zA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		5 / 12 PRO A 216
GLY A 178
GLY A 260
ASP A 241
LEU A 263
 None
 1.13A 5wwsA-4j3zA:
undetectable		 5wwsA-4j3zA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		4 / 4 GLY A  39
LEU A  26
VAL A 316
GLU A  40
 None
 1.39A 5yw0A-4j3zA:
undetectable		 5yw0A-4j3zA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		3 / 3 TRP A 233
GLU A 236
GLU A 335
 None
 0.99A 6fhwA-4j3zA:
undetectable		 6fhwA-4j3zA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Jannaschia
sp.
CCS1) 		4 / 6 PRO A  14
TRP A  24
ILE A 337
GLY A  18
 None
 0.92A 6gqiA-4j3zA:
undetectable		 6gqiA-4j3zA:
24.69