SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j4b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 4j4b PYLD
(Methanosarcina
barkeri) 		6 / 12 ALA A 119
ALA A 252
LEU A 255
SER A 257
LEU A  67
ILE A  70
 None
 1.38A 2h79A-4j4bA:
undetectable		 2h79A-4j4bA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4j4b PYLD
(Methanosarcina
barkeri) 		5 / 12 ILE A  99
ILE A  31
ILE A  70
THR A  71
LEU A  67
 None
 1.14A 2qo5A-4j4bA:
undetectable		 2qo5A-4j4bA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC201_1
(PROTEIN S100-A4)		 4j4b PYLD
(Methanosarcina
barkeri) 		5 / 9 PHE A  74
PHE A  76
CYH A 124
ILE A 128
CYH A  35
 None
 1.36A 3ko0A-4j4bA:
undetectable
3ko0C-4j4bA:
undetectable		 3ko0A-4j4bA:
16.92
3ko0C-4j4bA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4j4b PYLD
(Methanosarcina
barkeri) 		5 / 10 ILE A 132
THR A  27
VAL A  23
ILE A  31
SER A 253
 None
 1.39A 3kpbD-4j4bA:
undetectable		 3kpbD-4j4bA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 4j4b PYLD
(Methanosarcina
barkeri) 		4 / 7 ASN A 208
ALA A 229
THR A 223
LEU A 242
 None
NA  A 902 ( 4.1A)
None
None
 0.97A 3t3sC-4j4bA:
undetectable		 3t3sC-4j4bA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4j4b PYLD
(Methanosarcina
barkeri) 		4 / 5 LEU A 101
ALA A 103
THR A 251
PHE A  63
 None
0TF  A 904 (-4.0A)
None
0TF  A 904 (-3.8A)
 1.32A 3vasB-4j4bA:
2.9		 3vasB-4j4bA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 4j4b PYLD
(Methanosarcina
barkeri) 		4 / 5 THR A  71
ILE A  70
GLU A 245
PHE A  63
 None
None
MG  A 903 ( 3.9A)
0TF  A 904 (-3.8A)
 1.48A 4ac9C-4j4bA:
undetectable		 4ac9C-4j4bA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4j4b PYLD
(Methanosarcina
barkeri) 		4 / 5 THR A  71
ILE A  70
GLU A 245
PHE A  63
 None
None
MG  A 903 ( 3.9A)
0TF  A 904 (-3.8A)
 1.49A 4acaC-4j4bA:
undetectable		 4acaC-4j4bA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4j4b PYLD
(Methanosarcina
barkeri) 		4 / 6 SER A  66
THR A  71
ILE A  70
PHE A  63
 None
None
None
0TF  A 904 (-3.8A)
 1.05A 4acbC-4j4bA:
undetectable		 4acbC-4j4bA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4j4b PYLD
(Methanosarcina
barkeri) 		4 / 5 THR A  71
ILE A  70
GLU A 245
PHE A  63
 None
None
MG  A 903 ( 3.9A)
0TF  A 904 (-3.8A)
 1.34A 4acbC-4j4bA:
undetectable		 4acbC-4j4bA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 4j4b PYLD
(Methanosarcina
barkeri) 		4 / 6 ASN A 208
ALA A 229
THR A 223
LEU A 242
 None
NA  A 902 ( 4.1A)
None
None
 1.02A 4ejgD-4j4bA:
undetectable		 4ejgD-4j4bA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4j4b PYLD
(Methanosarcina
barkeri) 		6 / 12 ALA A 119
ALA A 252
LEU A 255
SER A 257
LEU A  67
ILE A  70
 None
 1.37A 4lnxA-4j4bA:
undetectable		 4lnxA-4j4bA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4j4b PYLD
(Methanosarcina
barkeri) 		4 / 5 TYR A  39
GLY A 250
GLU A 131
VAL A  26
 None
MG  A 903 (-4.0A)
None
None
 1.01A 4nkvD-4j4bA:
undetectable		 4nkvD-4j4bA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4j4b PYLD
(Methanosarcina
barkeri) 		4 / 6 PHE A  74
GLY A  75
ILE A  50
LEU A 259
 None
 0.76A 4o8fB-4j4bA:
undetectable		 4o8fB-4j4bA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4j4b PYLD
(Methanosarcina
barkeri) 		5 / 12 LEU A 101
PHE A  63
PHE A 108
THR A 125
PHE A  76
 None
0TF  A 904 (-3.8A)
None
NAI  A 901 (-3.4A)
None
 1.18A 5eskA-4j4bA:
undetectable		 5eskA-4j4bA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 4j4b PYLD
(Methanosarcina
barkeri) 		5 / 12 LEU A 101
PHE A  63
PHE A 108
THR A 125
PHE A  76
 None
0TF  A 904 (-3.8A)
None
NAI  A 901 (-3.4A)
None
 1.18A 5fsaB-4j4bA:
undetectable		 5fsaB-4j4bA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4j4b PYLD
(Methanosarcina
barkeri) 		4 / 5 ILE A  59
LEU A 247
HIS A  68
VAL A  80
 0TF  A 904 (-4.3A)
0TF  A 904 ( 4.5A)
None
None
 0.82A 5jmnB-4j4bA:
undetectable		 5jmnB-4j4bA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4j4b PYLD
(Methanosarcina
barkeri) 		5 / 12 PHE A 108
GLY A 248
ASN A  13
ASP A  20
ILE A  31
 None
MG  A 903 ( 4.8A)
None
None
None
 1.01A 6b3aA-4j4bA:
3.7		 6b3aA-4j4bA:
17.00