SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 ALA A 250
VAL A 242
TRP A 277
 None
 0.78A 1av2A-4j4jA:
undetectable
1av2B-4j4jA:
undetectable		 1av2A-4j4jA:
5.67
1av2B-4j4jA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 TRP A 277
ALA A 250
VAL A 242
 None
 0.86A 1av2C-4j4jA:
undetectable
1av2D-4j4jA:
undetectable		 1av2C-4j4jA:
5.67
1av2D-4j4jA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 THR A -19
THR A -17
PRO A -20
 None
 0.80A 1dscC-4j4jA:
undetectable		 1dscC-4j4jA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 THR A -19
THR A -17
PRO A -20
 None
 0.86A 1unjL-4j4jA:
undetectable		 1unjL-4j4jA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 THR A -19
THR A -17
PRO A -20
 None
 0.82A 1unjW-4j4jA:
undetectable		 1unjW-4j4jA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 THR A -17
PRO A -20
THR A -19
 None
 0.86A 1unjX-4j4jA:
undetectable		 1unjX-4j4jA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 THR A -17
PRO A -20
THR A -19
 None
 0.84A 1unmE-4j4jA:
undetectable		 1unmE-4j4jA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 THR A -19
THR A -17
PRO A -20
 None
 0.83A 1unmE-4j4jA:
undetectable		 1unmE-4j4jA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 ALA A 250
VAL A 242
TRP A 277
 None
 0.78A 1w5uA-4j4jA:
undetectable
1w5uB-4j4jA:
undetectable		 1w5uA-4j4jA:
5.67
1w5uB-4j4jA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 TRP A 277
ALA A 250
VAL A 242
 None
 0.83A 1w5uA-4j4jA:
undetectable
1w5uB-4j4jA:
undetectable		 1w5uA-4j4jA:
5.67
1w5uB-4j4jA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 THR A -19
PRO A -21
THR A -17
 None
 0.72A 209dC-4j4jA:
undetectable		 209dC-4j4jA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 ALA A 250
VAL A 242
TRP A 277
 None
 0.89A 2izqA-4j4jA:
undetectable
2izqB-4j4jA:
undetectable		 2izqA-4j4jA:
5.67
2izqB-4j4jA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 TRP A 277
ALA A 250
VAL A 242
 None
 0.81A 2izqC-4j4jA:
undetectable
2izqD-4j4jA:
undetectable		 2izqC-4j4jA:
5.67
2izqD-4j4jA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 TRP A 277
ALA A 250
VAL A 242
 None
 0.99A 3l8lA-4j4jA:
undetectable
3l8lB-4j4jA:
undetectable		 3l8lA-4j4jA:
5.67
3l8lB-4j4jA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4j4j DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 TRP A 277
ALA A 250
VAL A 242
 None
 0.85A 3l8lC-4j4jA:
undetectable
3l8lD-4j4jA:
undetectable		 3l8lC-4j4jA:
5.67
3l8lD-4j4jA:
5.67