SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		3 / 3 THR A 113
THR A 115
PRO A 112
 None
 0.75A 1dscC-4j4sA:
undetectable		 1dscC-4j4sA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		4 / 6 LYS A 184
MET A 185
ALA A 188
GLU A 192
 None
None
None
NA  A 303 ( 3.5A)
 1.18A 1qhyA-4j4sA:
undetectable		 1qhyA-4j4sA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		4 / 6 PRO A 130
LYS A 123
ALA A 119
GLU A 143
 None
 1.17A 1qhyA-4j4sA:
undetectable		 1qhyA-4j4sA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		3 / 3 THR A 115
PRO A 112
THR A 113
 None
 0.87A 1unjR-4j4sA:
undetectable		 1unjR-4j4sA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		4 / 6 SER A 189
ALA A 188
THR A 191
ASN A 195
 None
 1.07A 1yvpB-4j4sA:
undetectable		 1yvpB-4j4sA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		4 / 6 THR A  54
PHE A  56
LEU A  92
LEU A  86
 None
 1.15A 3bgdA-4j4sA:
undetectable		 3bgdA-4j4sA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		4 / 8 ILE A 224
LEU A 166
ALA A 238
ALA A 239
 None
 0.75A 3r9tA-4j4sA:
undetectable		 3r9tA-4j4sA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		4 / 7 ILE A 224
LEU A 166
ALA A 238
ALA A 239
 None
 0.74A 3r9tB-4j4sA:
undetectable		 3r9tB-4j4sA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		3 / 3 THR A 115
PRO A 112
THR A 113
 None
 0.88A 4hivD-4j4sA:
undetectable		 4hivD-4j4sA:
4.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		9 / 11 GLY A  65
ASN A  66
ALA A  96
VAL A 105
GLN A 109
PRO A 127
MET A 147
PHE A 177
ILE A 181
 None
 0.81A 4j4vA-4j4sA:
36.9		 4j4vA-4j4sA:
98.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		9 / 10 GLY A  65
ASN A  66
ARG A  95
ALA A  96
VAL A 105
GLN A 109
PRO A 127
MET A 147
PHE A 177
 None
 0.76A 4j4vB-4j4sA:
35.8		 4j4vB-4j4sA:
98.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		5 / 8 ASN A  66
PRO A 127
MET A 147
PHE A 177
ILE A 181
 None
 0.92A 4j4vC-4j4sA:
36.5		 4j4vC-4j4sA:
98.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		5 / 8 GLY A  65
ASN A  66
ARG A  95
PRO A 127
PHE A 177
 None
 0.71A 4j4vC-4j4sA:
36.5		 4j4vC-4j4sA:
98.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		5 / 8 GLY A  65
ASN A  66
PRO A 127
MET A 147
PHE A 177
 None
 0.78A 4j4vC-4j4sA:
36.5		 4j4vC-4j4sA:
98.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		8 / 11 GLY A  65
ALA A  96
VAL A 105
GLN A 109
PRO A 127
MET A 147
PHE A 177
ILE A 181
 None
 0.89A 4j4vD-4j4sA:
36.8
4j4vE-4j4sA:
36.2		 4j4vD-4j4sA:
98.79
4j4vE-4j4sA:
98.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		8 / 11 GLY A  65
ASN A  66
ALA A  96
VAL A 105
GLN A 109
PRO A 127
MET A 147
PHE A 177
 None
 0.70A 4j4vD-4j4sA:
36.8
4j4vE-4j4sA:
36.2		 4j4vD-4j4sA:
98.79
4j4vE-4j4sA:
98.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		7 / 11 GLY A  65
ASN A  66
ARG A  95
ALA A  96
VAL A 105
GLN A 109
PRO A 127
 None
 0.93A 4j4vD-4j4sA:
36.8
4j4vE-4j4sA:
36.2		 4j4vD-4j4sA:
98.79
4j4vE-4j4sA:
98.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		8 / 10 GLY A  65
ASN A  66
ALA A  96
VAL A 105
GLN A 109
PRO A 127
MET A 147
PHE A 177
 None
 0.72A 4j4vA-4j4sA:
36.9
4j4vE-4j4sA:
36.2		 4j4vA-4j4sA:
98.79
4j4vE-4j4sA:
98.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		3 / 3 ALA A 131
ASN A 134
LEU A 135
 None
 0.16A 5i1nB-4j4sA:
undetectable		 5i1nB-4j4sA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		3 / 3 ALA A 131
ASN A 134
LEU A 135
 None
 0.31A 5i1oC-4j4sA:
undetectable		 5i1oC-4j4sA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		3 / 3 ALA A 131
ASN A 134
LEU A 135
 None
 0.31A 5i1pA-4j4sA:
undetectable		 5i1pA-4j4sA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		3 / 3 VAL A 205
SER A 171
MET A 145
 None
 0.78A 5ikqA-4j4sA:
undetectable		 5ikqA-4j4sA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4j4s NUCLEOCAPSID PROTEIN
(SFTS
phlebovirus) 		3 / 3 GLN A 174
TRP A 173
VAL A 128
 None
 1.12A 6auuA-4j4sA:
undetectable		 6auuA-4j4sA:
18.59