SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4j4x NP PROTEIN
(Sandfly
fever
Naples
phlebovirus) 		5 / 11 ILE A 158
PHE A 155
ILE A 240
LEU A 224
THR A 120
 None
 1.20A 3qg2B-4j4xA:
undetectable		 3qg2B-4j4xA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4j4x NP PROTEIN
(Sandfly
fever
Naples
phlebovirus) 		5 / 11 THR A 120
ALA A 123
LEU A 127
SER A 113
VAL A  88
 None
 1.34A 4claA-4j4xA:
undetectable		 4claA-4j4xA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4j4x NP PROTEIN
(Sandfly
fever
Naples
phlebovirus) 		4 / 8 SER A 110
ASN A 101
GLU A  99
ASN A  66
 None
 0.96A 4d33A-4j4xA:
undetectable		 4d33A-4j4xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4j4x NP PROTEIN
(Sandfly
fever
Naples
phlebovirus) 		4 / 8 SER A 110
ASN A 101
GLU A  99
ASN A  66
 None
 0.84A 4d39A-4j4xA:
undetectable		 4d39A-4j4xA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4j4x NP PROTEIN
(Sandfly
fever
Naples
phlebovirus) 		6 / 11 GLY A  70
ASN A  71
LYS A  72
PRO A 132
PHE A 182
ILE A 186
 None
 1.10A 4j4vA-4j4xA:
31.4		 4j4vA-4j4xA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 4j4x NP PROTEIN
(Sandfly
fever
Naples
phlebovirus) 		5 / 10 GLY A  70
ASN A  71
LYS A  72
PRO A 132
PHE A 182
 None
 0.67A 4j4vB-4j4xA:
30.4		 4j4vB-4j4xA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 4j4x NP PROTEIN
(Sandfly
fever
Naples
phlebovirus) 		6 / 8 GLY A  70
ASN A  71
LYS A  72
PRO A 132
PHE A 182
ILE A 186
 None
 0.93A 4j4vC-4j4xA:
31.3		 4j4vC-4j4xA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4j4x NP PROTEIN
(Sandfly
fever
Naples
phlebovirus) 		5 / 11 GLY A  70
ASN A  71
PRO A 132
PHE A 182
ILE A 186
 None
 0.60A 4j4vD-4j4xA:
31.1
4j4vE-4j4xA:
30.9		 4j4vD-4j4xA:
36.22
4j4vE-4j4xA:
36.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4j4x NP PROTEIN
(Sandfly
fever
Naples
phlebovirus) 		4 / 5 ALA A  31
TYR A  32
HIS A 152
PRO A  37
 None
 1.38A 4ze2A-4j4xA:
undetectable		 4ze2A-4j4xA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4j4x NP PROTEIN
(Sandfly
fever
Naples
phlebovirus) 		5 / 12 LEU A 124
THR A 120
VAL A 117
SER A 113
THR A 185
 None
 1.44A 5v1tA-4j4xA:
undetectable		 5v1tA-4j4xA:
20.69