SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A  72
VAL A  70
GLY A  76
GLY A  77
 None
 0.85A 1ekjE-4j5tA:
undetectable
1ekjF-4j5tA:
undetectable		 1ekjE-4j5tA:
14.91
1ekjF-4j5tA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 791
ASP A 404
ILE A 400
ILE A 411
 None
 0.81A 1p7lD-4j5tA:
undetectable		 1p7lD-4j5tA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 791
ASP A 404
ILE A 400
ILE A 411
 None
 0.83A 1p7lC-4j5tA:
undetectable		 1p7lC-4j5tA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 771
ASN A 772
TRP A 710
 None
 1.05A 1r15C-4j5tA:
undetectable		 1r15C-4j5tA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 771
ASN A 772
TRP A 710
 None
 1.03A 1r15D-4j5tA:
undetectable		 1r15D-4j5tA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 771
ASN A 772
TRP A 710
 None
 1.04A 1r15E-4j5tA:
undetectable		 1r15E-4j5tA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 771
ASN A 772
TRP A 710
 None
 1.01A 1r15F-4j5tA:
undetectable		 1r15F-4j5tA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 791
ASP A 404
ILE A 400
ILE A 411
 None
 0.79A 1rg9B-4j5tA:
undetectable		 1rg9B-4j5tA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 791
ASP A 404
ILE A 400
ILE A 411
 None
 0.81A 1rg9A-4j5tA:
undetectable		 1rg9A-4j5tA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 791
ASP A 404
ILE A 400
ILE A 411
 None
 0.80A 1rg9D-4j5tA:
undetectable		 1rg9D-4j5tA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 791
ASP A 404
ILE A 400
ILE A 411
 None
 0.82A 1rg9C-4j5tA:
undetectable		 1rg9C-4j5tA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 247
ASP A 218
SER A 214
TYR A 256
 None
 1.30A 2bteA-4j5tA:
3.2		 2bteA-4j5tA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 627
ASN A 582
ILE A 638
ALA A 585
TYR A 533
 None
 1.30A 2gl0B-4j5tA:
undetectable
2gl0C-4j5tA:
undetectable		 2gl0B-4j5tA:
11.93
2gl0C-4j5tA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 408
LEU A 336
ILE A 339
SER A  11
PHE A 376
 None
 1.04A 2w9sD-4j5tA:
undetectable		 2w9sD-4j5tA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 408
LEU A 336
ILE A 339
SER A  11
PHE A 376
 None
 1.06A 2w9sF-4j5tA:
undetectable		 2w9sF-4j5tA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A  52
GLN A  47
GLN A 213
SER A  46
 None
 1.07A 2xz5B-4j5tA:
undetectable
2xz5E-4j5tA:
undetectable		 2xz5B-4j5tA:
14.19
2xz5E-4j5tA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 GLN A  47
GLN A 213
SER A  46
SER A  52
 None
 1.14A 2xz5C-4j5tA:
undetectable
2xz5D-4j5tA:
undetectable		 2xz5C-4j5tA:
14.19
2xz5D-4j5tA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		5 / 11 MET A   1
LEU A 497
PHE A 409
ILE A 511
VAL A 602
 None
 1.48A 3aqiA-4j5tA:
undetectable		 3aqiA-4j5tA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  12
GLU A 410
SER A  11
PHE A   7
 None
 1.26A 3i9jB-4j5tA:
undetectable		 3i9jB-4j5tA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  75
PHE A 376
SER A 414
ALA A 408
LEU A 407
 None
 1.33A 3lw5B-4j5tA:
undetectable		 3lw5B-4j5tA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 216
VAL A 123
SER A 121
 None
 0.71A 3n8xB-4j5tA:
undetectable		 3n8xB-4j5tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 447
GLU A 393
GLU A 429
PRO A 380
 None
 1.35A 3ql6A-4j5tA:
undetectable		 3ql6A-4j5tA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 522
ILE A 615
GLU A 550
TYR A 552
 None
 1.05A 3rqwI-4j5tA:
1.2
3rqwJ-4j5tA:
1.5		 3rqwI-4j5tA:
17.52
3rqwJ-4j5tA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A   8
ASN A   9
GLU A 410
 None
NAG  A1001 (-2.3A)
None
 0.80A 3v4tA-4j5tA:
undetectable
3v4tC-4j5tA:
undetectable		 3v4tA-4j5tA:
20.21
3v4tC-4j5tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 247
ASP A 218
SER A 214
TYR A 256
 None
 1.30A 4arcA-4j5tA:
undetectable		 4arcA-4j5tA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 PRO A  73
TYR A  17
GLY A 337
 None
 0.74A 4g2zA-4j5tA:
undetectable		 4g2zA-4j5tA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 755
MET A 716
ASP A 683
 None
 0.82A 4j7xB-4j5tA:
undetectable		 4j7xB-4j5tA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 4 PHE A 475
HIS A 601
GLY A 473
ILE A 469
 None
 1.35A 4k50E-4j5tA:
1.6		 4k50E-4j5tA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 4 PHE A 475
HIS A 601
GLY A 473
ILE A 469
 None
 1.34A 4k50M-4j5tA:
1.9		 4k50M-4j5tA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 791
ASP A 404
ILE A 400
ILE A 411
 None
 0.89A 4kttD-4j5tA:
undetectable		 4kttD-4j5tA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 791
ASP A 404
ILE A 400
ILE A 411
 None
 0.95A 4ndnD-4j5tA:
undetectable		 4ndnD-4j5tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 530
ILE A 615
ILE A 546
LEU A 581
 None
 0.73A 4o8fB-4j5tA:
undetectable		 4o8fB-4j5tA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 196
MET A 141
TYR A 125
 None
 0.89A 4p6xG-4j5tA:
undetectable		 4p6xG-4j5tA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 664
LEU A 693
PHE A 662
ALA A 725
ASP A 724
 None
 1.23A 4wnuC-4j5tA:
undetectable		 4wnuC-4j5tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  54
ASP A  83
TRP A  41
 None
 1.14A 4xdqA-4j5tA:
undetectable		 4xdqA-4j5tA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 393
ILE A 430
ILE A 426
MET A 418
 None
 0.72A 4xumA-4j5tA:
undetectable		 4xumA-4j5tA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 638
ARG A 572
ALA A 587
ASN A 582
PHE A 650
 None
 1.37A 4zo1X-4j5tA:
undetectable		 4zo1X-4j5tA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 269
ASP A 168
PHE A 271
VAL A 122
 None
 1.16A 5a1rA-4j5tA:
undetectable		 5a1rA-4j5tA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 589
THR A 593
ARG A 523
 None
 0.68A 5b2sB-4j5tA:
2.0		 5b2sB-4j5tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 589
THR A 593
ARG A 523
 None
 0.72A 5b2tB-4j5tA:
undetectable		 5b2tB-4j5tA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 383
PRO A  59
ALA A 783
PHE A 786
ASN A  20
 None
 1.38A 5c8tB-4j5tA:
undetectable		 5c8tB-4j5tA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 336
GLY A 337
ARG A 382
TYR A 403
LEU A 407
 None
 1.34A 5czyA-4j5tA:
undetectable		 5czyA-4j5tA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 155
LYS A 157
LYS A 136
 None
 0.79A 5dbyA-4j5tA:
undetectable		 5dbyA-4j5tA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 628
ILE A 667
SER A 671
 None
 0.83A 5gqbA-4j5tA:
undetectable		 5gqbA-4j5tA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 791
ASP A 404
ILE A 400
ILE A 411
 None
 0.91A 5t8sA-4j5tA:
undetectable		 5t8sA-4j5tA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 698
PRO A 684
TYR A 691
 None
 0.96A 5tzoB-4j5tA:
undetectable		 5tzoB-4j5tA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 195
ASN A 250
LEU A 139
GLN A 199
 None
 1.46A 5xdhA-4j5tA:
undetectable
5xdhC-4j5tA:
undetectable		 5xdhA-4j5tA:
7.16
5xdhC-4j5tA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 337
ARG A 382
VAL A 379
PHE A 342
GLY A 338
 None
 1.07A 5yjsA-4j5tA:
1.8		 5yjsA-4j5tA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A  46
ARG A 209
ARG A  54
ASP A  48
 None
 1.18A 5zw4A-4j5tA:
undetectable		 5zw4A-4j5tA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A  46
ARG A 209
ARG A  54
ASP A 210
 None
 1.27A 5zw4A-4j5tA:
undetectable		 5zw4A-4j5tA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 5 GLN A   5
ASN A   9
THR A   8
LEU A  12
 NAG  A1001 (-4.7A)
NAG  A1001 (-2.3A)
None
None
 1.14A 6d8pA-4j5tA:
undetectable		 6d8pA-4j5tA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 664
ILE A 451
MET A 592
GLY A 590
 None
 1.00A 6hd6A-4j5tA:
undetectable		 6hd6A-4j5tA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 469
ILE A 599
PHE A 405
PHE A 409
MET A 401
 None
 1.35A 6j21A-4j5tA:
undetectable		 6j21A-4j5tA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 805
HIS A 601
GLU A 470
GLU A 463
 None
 1.37A 6mn4F-4j5tA:
undetectable		 6mn4F-4j5tA:
16.21