SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DHF_B_FOLB187_0 (DIHYDROFOLATE REDUCTASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 12	ILE A 253 ALA A 256 PHE A 375 ILE A 406 LEU A 133	None	1.20A	1dhfB-4j6cA: undetectable	1dhfB-4j6cA: 15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DLS_A_MTXA188_1 (DIHYDROFOLATE REDUCTASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 12	ILE A 253 ALA A 256 PHE A 375 ILE A 406 LEU A 133	None	1.17A	1dlsA-4j6cA: undetectable	1dlsA-4j6cA: 15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DRF_A_FOLA187_0 (DIHYDROFOLATE REDUCTASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 12	ILE A 253 ALA A 256 PHE A 375 ILE A 406 LEU A 133	None	1.03A	1drfA-4j6cA: undetectable	1drfA-4j6cA: 15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM9_A_9CRA201_2 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	3 / 3	GLN A 169 ILE A 235 HIS A 197	None	0.72A	1fm9A-4j6cA: undetectable	1fm9A-4j6cA: 20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GSE_A_EAAA224_1 (GLUTATHIONE TRANSFERASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 12	LEU A 60 LEU A 54 VAL A 45 MET A 296 ALA A 42	None	1.23A	1gseA-4j6cA: undetectable	1gseA-4j6cA: 19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HMY_A_SAMA328_0 (HAEIII METHYLTRANSFERASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	4 / 8	ASP A 338 ILE A 339 THR A 340 LEU A 269	None	0.87A	1hmyA-4j6cA: undetectable	1hmyA-4j6cA: 20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K74_A_9CRA463_2 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	3 / 3	GLN A 169 ILE A 235 HIS A 197	None	0.72A	1k74A-4j6cA: undetectable	1k74A-4j6cA: 20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DG4_A_RAPA501_1 (FK506-BINDING PROTEIN 1A)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 11	GLU A 247 VAL A 250 ILE A 253 ILE A 122 PHE A 149	None	1.26A	2dg4A-4j6cA: undetectable	2dg4A-4j6cA: 15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OKC_B_SAMB500_1 (TYPE I RESTRICTION ENZYME STYSJI M PROTEIN)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	4 / 6	THR A 23 THR A 46 ASP A 326 THR A 328	None	1.30A	2okcB-4j6cA: undetectable	2okcB-4j6cA: 23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD2_B_CHDB1_0 (FERROCHELATASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 10	LEU A 252 PRO A 372 VAL A 270 GLY A 276 TRP A 277	HEM A 502 ( 4.6A) None None None None	1.35A	2qd2B-4j6cA: undetectable	2qd2B-4j6cA: 21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YA7_A_ZMRA1776_2 (NEURAMINIDASE A)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	4 / 6	ASP A 302 ILE A 303 LEU A 305 GLU A 314	None	1.05A	2ya7A-4j6cA: undetectable	2ya7A-4j6cA: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YA7_B_ZMRB1776_2 (NEURAMINIDASE A)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	4 / 6	ASP A 302 ILE A 303 LEU A 305 GLU A 314	None	1.04A	2ya7B-4j6cA: undetectable	2ya7B-4j6cA: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YA7_D_ZMRD1776_2 (NEURAMINIDASE A)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	4 / 6	ASP A 302 ILE A 303 LEU A 305 GLU A 314	None	1.06A	2ya7D-4j6cA: undetectable	2ya7D-4j6cA: 24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3A50_D_VD3D2001_1 (VITAMIN D HYDROXYLASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 12	ILE A 12 LEU A 396 LEU A 294 ALA A 44 THR A 46	None FMT A 504 (-4.4A) HEM A 502 ( 4.0A) None None	1.04A	3a50D-4j6cA: 46.2	3a50D-4j6cA: 33.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E4E_A_4PZA501_1 (CYTOCHROME P450 2E1)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	3 / 3	ALA A 244 THR A 248 CYH A 357	HEM A 502 (-3.2A) HEM A 502 ( 3.4A) HEM A 502 (-2.2A)	0.43A	3e4eA-4j6cA: 30.7	3e4eA-4j6cA: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E4E_B_4PZB501_1 (CYTOCHROME P450 2E1)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	3 / 3	ALA A 244 THR A 248 CYH A 357	HEM A 502 (-3.2A) HEM A 502 ( 3.4A) HEM A 502 (-2.2A)	0.35A	3e4eB-4j6cA: 30.7	3e4eB-4j6cA: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FL9_D_TOPD200_1 (DIHYDROFOLATE REDUCTASE (DHFR))	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 9	ALA A 150 VAL A 257 ILE A 390 LEU A 387 PHE A 404	None	1.49A	3fl9D-4j6cA: undetectable	3fl9D-4j6cA: 16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IV6_B_SAMB301_0 (PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 12	GLY A 137 ILE A 406 ASP A 132 LEU A 133 ARG A 377	None	1.18A	3iv6B-4j6cA: undetectable	3iv6B-4j6cA: 23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IV6_D_SAMD301_0 (PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 12	GLY A 137 ILE A 406 ASP A 132 LEU A 133 ARG A 377	None	1.20A	3iv6D-4j6cA: undetectable	3iv6D-4j6cA: 23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KPB_D_SAMD1000_0 (UNCHARACTERIZED PROTEIN MJ0100)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 10	ILE A 220 ASP A 214 THR A 216 VAL A 234 ILE A 235	None	1.45A	3kpbD-4j6cA: undetectable	3kpbD-4j6cA: 17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MDT_B_VORB506_1 (CHOLESTEROL 24-HYDROXYLASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 11	LEU A 153 PHE A 149 ILE A 253 ALA A 373 ALA A 367	None	1.12A	3mdtB-4j6cA: 32.3	3mdtB-4j6cA: 24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N0H_A_TOPA187_1 (DIHYDROFOLATE REDUCTASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 11	ILE A 253 ALA A 256 PHE A 375 ILE A 406 LEU A 133	None	1.14A	3n0hA-4j6cA: undetectable	3n0hA-4j6cA: 15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU6_D_SAMD300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 12	TYR A 176 SER A 159 MET A 155 ASP A 214 LEU A 215	None	1.17A	3ou6D-4j6cA: undetectable	3ou6D-4j6cA: 20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU7_A_SAMA300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 12	TYR A 176 SER A 159 MET A 155 ASP A 214 LEU A 215	None	1.17A	3ou7A-4j6cA: undetectable	3ou7A-4j6cA: 20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_D_9PLD501_1 (CYTOCHROME P450 2E1)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	4 / 6	PHE A 375 LEU A 145 ALA A 259 LEU A 371	None	0.93A	3t3zD-4j6cA: 30.3	3t3zD-4j6cA: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VW7_A_VPXA2001_1 (PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 12	LEU A 254 LEU A 130 LEU A 133 ALA A 370 ALA A 373	None	1.17A	3vw7A-4j6cA: undetectable	3vw7A-4j6cA: 23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EAH_F_ACTF402_0 (ACTIN, ALPHA SKELETAL MUSCLE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	3 / 3	PHE A 337 ASP A 333 ARG A 341	None	0.82A	4eahF-4j6cA: undetectable	4eahF-4j6cA: 21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EAH_G_ACTG401_0 (ACTIN, ALPHA SKELETAL MUSCLE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	3 / 3	PHE A 337 ASP A 333 ARG A 341	None	0.81A	4eahG-4j6cA: undetectable	4eahG-4j6cA: 21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J6D_A_TESA503_1 (CYTOCHROME P450 MONOOXYGENASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	12 / 12	MET A 84 PHE A 92 PHE A 179 PHE A 180 GLN A 239 ALA A 240 ALA A 243 ALA A 244 THR A 248 VAL A 291 LEU A 294 GLN A 398	STR A 501 (-4.3A) STR A 501 (-4.0A) STR A 501 (-4.0A) None STR A 501 ( 4.5A) STR A 501 (-3.6A) STR A 501 ( 3.7A) HEM A 502 (-3.2A) HEM A 502 ( 3.4A) STR A 501 (-4.5A) HEM A 502 ( 4.0A) STR A 501 (-3.1A)	0.29A	4j6dA-4j6cA: 70.4	4j6dA-4j6cA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J6D_B_TESB502_1 (CYTOCHROME P450 MONOOXYGENASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	12 / 12	MET A 84 PHE A 92 PHE A 179 PHE A 180 GLN A 239 ALA A 240 ALA A 243 ALA A 244 THR A 248 VAL A 291 LEU A 294 GLN A 398	STR A 501 (-4.3A) STR A 501 (-4.0A) STR A 501 (-4.0A) None STR A 501 ( 4.5A) STR A 501 (-3.6A) STR A 501 ( 3.7A) HEM A 502 (-3.2A) HEM A 502 ( 3.4A) STR A 501 (-4.5A) HEM A 502 ( 4.0A) STR A 501 (-3.1A)	0.32A	4j6dB-4j6cA: 70.2	4j6dB-4j6cA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4JBT_A_ASDA501_1 (CYTOCHROME P450 MONOOXYGENASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	12 / 12	MET A 84 PHE A 92 PHE A 179 PHE A 180 GLN A 239 ALA A 240 ALA A 243 ALA A 244 THR A 248 VAL A 291 LEU A 294 GLN A 398	STR A 501 (-4.3A) STR A 501 (-4.0A) STR A 501 (-4.0A) None STR A 501 ( 4.5A) STR A 501 (-3.6A) STR A 501 ( 3.7A) HEM A 502 (-3.2A) HEM A 502 ( 3.4A) STR A 501 (-4.5A) HEM A 502 ( 4.0A) STR A 501 (-3.1A)	0.26A	4jbtA-4j6cA: 70.5	4jbtA-4j6cA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4JBT_B_ASDB502_1 (CYTOCHROME P450 MONOOXYGENASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	11 / 11	MET A 84 PHE A 92 PHE A 179 GLN A 239 ALA A 240 ALA A 243 ALA A 244 THR A 248 VAL A 291 LEU A 294 GLN A 398	STR A 501 (-4.3A) STR A 501 (-4.0A) STR A 501 (-4.0A) STR A 501 ( 4.5A) STR A 501 (-3.6A) STR A 501 ( 3.7A) HEM A 502 (-3.2A) HEM A 502 ( 3.4A) STR A 501 (-4.5A) HEM A 502 ( 4.0A) STR A 501 (-3.1A)	0.26A	4jbtB-4j6cA: 70.3	4jbtB-4j6cA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4JBT_B_ASDB502_1 (CYTOCHROME P450 MONOOXYGENASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	6 / 11	MET A 84 PHE A 92 PHE A 180 ALA A 240 ALA A 243 LEU A 294	STR A 501 (-4.3A) STR A 501 (-4.0A) None STR A 501 (-3.6A) STR A 501 ( 3.7A) HEM A 502 ( 4.0A)	1.47A	4jbtB-4j6cA: 70.3	4jbtB-4j6cA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WAN_C_ACTC303_0 (BRANCHPOINT-BRIDGING PROTEIN)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	3 / 3	ASP A 132 ARG A 156 PRO A 152	None	1.00A	4wanC-4j6cA: undetectable	4wanC-4j6cA: 14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DX3_A_ESTA601_1 (ESTROGEN RECEPTOR)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 10	LEU A 362 ALA A 363 GLU A 366 GLY A 289 LEU A 285	HEM A 502 ( 4.6A) HEM A 502 (-2.9A) None None None	1.31A	5dx3A-4j6cA: 2.4	5dx3A-4j6cA: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DXG_B_ESTB601_1 (ESTROGEN RECEPTOR)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 11	LEU A 362 ALA A 363 GLU A 366 GLY A 289 LEU A 285	HEM A 502 ( 4.6A) HEM A 502 (-2.9A) None None None	1.26A	5dxgB-4j6cA: undetectable	5dxgB-4j6cA: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GS4_A_ESTA603_2 (ESTROGEN RECEPTOR)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	4 / 6	LEU A 153 LEU A 145 LEU A 254 LEU A 371	None	1.02A	5gs4A-4j6cA: 2.6	5gs4A-4j6cA: 20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GTR_A_ESTA601_1 (ESTROGEN RECEPTOR)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 12	LEU A 362 ALA A 363 GLU A 366 GLY A 289 LEU A 285	HEM A 502 ( 4.6A) HEM A 502 (-2.9A) None None None	1.07A	5gtrA-4j6cA: undetectable	5gtrA-4j6cA: 20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GWX_A_SAMA301_1 (GLYCINE SARCOSINE N-METHYLTRANSFERASE)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	3 / 3	ARG A 258 ASN A 392 ASP A 18	None	0.80A	5gwxA-4j6cA: undetectable	5gwxA-4j6cA: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HW8_D_FK5D201_1 (FK506-BINDING PROTEIN 1)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 11	VAL A 250 ILE A 253 ILE A 122 ILE A 369 PHE A 149	None	1.16A	5hw8D-4j6cA: undetectable	5hw8D-4j6cA: 13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5K9D_A_ACTA407_0 (DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	4 / 5	ASP A 187 GLN A 186 ARG A 189 GLU A 188	None	1.37A	5k9dA-4j6cA: undetectable	5k9dA-4j6cA: 22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_A_ACTA305_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	3 / 3	THR A 46 MET A 318 HIS A 293	None	1.00A	5uunA-4j6cA: undetectable	5uunA-4j6cA: 21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_A_SAMA902_0 (MRNA CAPPING ENZYME P5)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	5 / 12	LEU A 26 ALA A 322 GLU A 247 THR A 397 VAL A 395	None None None FMT A 504 (-3.0A) FMT A 504 (-3.8A)	1.20A	5x6yA-4j6cA: undetectable	5x6yA-4j6cA: 19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6A7J_A_TESA502_0 (CYTOCHROME P450)	4j6c	CYTOCHROME P450 MONOOXYGENASE (Nocardia farcinica)	4 / 7	PHE A 179 ALA A 243 ALA A 244 THR A 248	STR A 501 (-4.0A) STR A 501 ( 3.7A) HEM A 502 (-3.2A) HEM A 502 ( 3.4A)	0.26A	6a7jA-4j6cA: 58.6	6a7jA-4j6cA: 50.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DHF_B_FOLB187_0","DIHYDROFOLATE REDUCTASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"ILE A 253;ALA A 256;PHE A 375;ILE A 406;LEU A 133","None","1.20A","1dhfB-4j6cA:undetectable","1dhfB-4j6cA:15.31"],["1DLS_A_MTXA188_1","DIHYDROFOLATE REDUCTASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"ILE A 253;ALA A 256;PHE A 375;ILE A 406;LEU A 133","None","1.17A","1dlsA-4j6cA:undetectable","1dlsA-4j6cA:15.75"],["1DRF_A_FOLA187_0","DIHYDROFOLATE REDUCTASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"ILE A 253;ALA A 256;PHE A 375;ILE A 406;LEU A 133","None","1.03A","1drfA-4j6cA:undetectable","1drfA-4j6cA:15.31"],["1FM9_A_9CRA201_2","RETINOIC ACID RECEPTOR RXR-ALPHA","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",3,"GLN A 169;ILE A 235;HIS A 197","None","0.72A","1fm9A-4j6cA:undetectable","1fm9A-4j6cA:20.53"],["1GSE_A_EAAA224_1","GLUTATHIONE TRANSFERASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"LEU A  60;LEU A  54;VAL A  45;MET A 296;ALA A  42","None","1.23A","1gseA-4j6cA:undetectable","1gseA-4j6cA:19.61"],["1HMY_A_SAMA328_0","HAEIII METHYLTRANSFERASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",4,"ASP A 338;ILE A 339;THR A 340;LEU A 269","None","0.87A","1hmyA-4j6cA:undetectable","1hmyA-4j6cA:20.76"],["1K74_A_9CRA463_2","RETINOIC ACID RECEPTOR RXR-ALPHA","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",3,"GLN A 169;ILE A 235;HIS A 197","None","0.72A","1k74A-4j6cA:undetectable","1k74A-4j6cA:20.53"],["2DG4_A_RAPA501_1","FK506-BINDING PROTEIN 1A","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"GLU A 247;VAL A 250;ILE A 253;ILE A 122;PHE A 149","None","1.26A","2dg4A-4j6cA:undetectable","2dg4A-4j6cA:15.04"],["2OKC_B_SAMB500_1","TYPE I RESTRICTION ENZYME STYSJI M PROTEIN","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",4,"THR A  23;THR A  46;ASP A 326;THR A 328","None","1.30A","2okcB-4j6cA:undetectable","2okcB-4j6cA:23.25"],["2QD2_B_CHDB1_0","FERROCHELATASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"LEU A 252;PRO A 372;VAL A 270;GLY A 276;TRP A 277","HEM A 502 ( 4.6A);None;None;None;None","1.35A","2qd2B-4j6cA:undetectable","2qd2B-4j6cA:21.74"],["2YA7_A_ZMRA1776_2","NEURAMINIDASE A","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",4,"ASP A 302;ILE A 303;LEU A 305;GLU A 314","None","1.05A","2ya7A-4j6cA:undetectable","2ya7A-4j6cA:24.14"],["2YA7_B_ZMRB1776_2","NEURAMINIDASE A","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",4,"ASP A 302;ILE A 303;LEU A 305;GLU A 314","None","1.04A","2ya7B-4j6cA:undetectable","2ya7B-4j6cA:24.14"],["2YA7_D_ZMRD1776_2","NEURAMINIDASE A","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",4,"ASP A 302;ILE A 303;LEU A 305;GLU A 314","None","1.06A","2ya7D-4j6cA:undetectable","2ya7D-4j6cA:24.14"],["3A50_D_VD3D2001_1","VITAMIN D HYDROXYLASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"ILE A  12;LEU A 396;LEU A 294;ALA A  44;THR A  46","None;FMT A 504 (-4.4A);HEM A 502 ( 4.0A);None;None","1.04A","3a50D-4j6cA:46.2","3a50D-4j6cA:33.72"],["3E4E_A_4PZA501_1","CYTOCHROME P450 2E1","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",3,"ALA A 244;THR A 248;CYH A 357","HEM A 502 (-3.2A);HEM A 502 ( 3.4A);HEM A 502 (-2.2A)","0.43A","3e4eA-4j6cA:30.7","3e4eA-4j6cA:22.81"],["3E4E_B_4PZB501_1","CYTOCHROME P450 2E1","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",3,"ALA A 244;THR A 248;CYH A 357","HEM A 502 (-3.2A);HEM A 502 ( 3.4A);HEM A 502 (-2.2A)","0.35A","3e4eB-4j6cA:30.7","3e4eB-4j6cA:22.81"],["3FL9_D_TOPD200_1","DIHYDROFOLATE REDUCTASE (DHFR)","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"ALA A 150;VAL A 257;ILE A 390;LEU A 387;PHE A 404","None","1.49A","3fl9D-4j6cA:undetectable","3fl9D-4j6cA:16.79"],["3IV6_B_SAMB301_0","PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"GLY A 137;ILE A 406;ASP A 132;LEU A 133;ARG A 377","None","1.18A","3iv6B-4j6cA:undetectable","3iv6B-4j6cA:23.80"],["3IV6_D_SAMD301_0","PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"GLY A 137;ILE A 406;ASP A 132;LEU A 133;ARG A 377","None","1.20A","3iv6D-4j6cA:undetectable","3iv6D-4j6cA:23.80"],["3KPB_D_SAMD1000_0","UNCHARACTERIZED PROTEIN MJ0100","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"ILE A 220;ASP A 214;THR A 216;VAL A 234;ILE A 235","None","1.45A","3kpbD-4j6cA:undetectable","3kpbD-4j6cA:17.58"],["3MDT_B_VORB506_1","CHOLESTEROL 24-HYDROXYLASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"LEU A 153;PHE A 149;ILE A 253;ALA A 373;ALA A 367","None","1.12A","3mdtB-4j6cA:32.3","3mdtB-4j6cA:24.59"],["3N0H_A_TOPA187_1","DIHYDROFOLATE REDUCTASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"ILE A 253;ALA A 256;PHE A 375;ILE A 406;LEU A 133","None","1.14A","3n0hA-4j6cA:undetectable","3n0hA-4j6cA:15.31"],["3OU6_D_SAMD300_0","SAM-DEPENDENT METHYLTRANSFERASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"TYR A 176;SER A 159;MET A 155;ASP A 214;LEU A 215","None","1.17A","3ou6D-4j6cA:undetectable","3ou6D-4j6cA:20.72"],["3OU7_A_SAMA300_0","SAM-DEPENDENT METHYLTRANSFERASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"TYR A 176;SER A 159;MET A 155;ASP A 214;LEU A 215","None","1.17A","3ou7A-4j6cA:undetectable","3ou7A-4j6cA:20.72"],["3T3Z_D_9PLD501_1","CYTOCHROME P450 2E1","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",4,"PHE A 375;LEU A 145;ALA A 259;LEU A 371","None","0.93A","3t3zD-4j6cA:30.3","3t3zD-4j6cA:22.81"],["3VW7_A_VPXA2001_1","PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"LEU A 254;LEU A 130;LEU A 133;ALA A 370;ALA A 373","None","1.17A","3vw7A-4j6cA:undetectable","3vw7A-4j6cA:23.12"],["4EAH_F_ACTF402_0","ACTIN, ALPHA SKELETAL MUSCLE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",3,"PHE A 337;ASP A 333;ARG A 341","None","0.82A","4eahF-4j6cA:undetectable","4eahF-4j6cA:21.50"],["4EAH_G_ACTG401_0","ACTIN, ALPHA SKELETAL MUSCLE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",3,"PHE A 337;ASP A 333;ARG A 341","None","0.81A","4eahG-4j6cA:undetectable","4eahG-4j6cA:21.50"],["4J6D_A_TESA503_1","CYTOCHROME P450 MONOOXYGENASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",12,"MET A  84;PHE A  92;PHE A 179;PHE A 180;GLN A 239;ALA A 240;ALA A 243;ALA A 244;THR A 248;VAL A 291;LEU A 294;GLN A 398","STR A 501 (-4.3A);STR A 501 (-4.0A);STR A 501 (-4.0A);None;STR A 501 ( 4.5A);STR A 501 (-3.6A);STR A 501 ( 3.7A);HEM A 502 (-3.2A);HEM A 502 ( 3.4A);STR A 501 (-4.5A);HEM A 502 ( 4.0A);STR A 501 (-3.1A)","0.29A","4j6dA-4j6cA:70.4","4j6dA-4j6cA:100.00"],["4J6D_B_TESB502_1","CYTOCHROME P450 MONOOXYGENASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",12,"MET A  84;PHE A  92;PHE A 179;PHE A 180;GLN A 239;ALA A 240;ALA A 243;ALA A 244;THR A 248;VAL A 291;LEU A 294;GLN A 398","STR A 501 (-4.3A);STR A 501 (-4.0A);STR A 501 (-4.0A);None;STR A 501 ( 4.5A);STR A 501 (-3.6A);STR A 501 ( 3.7A);HEM A 502 (-3.2A);HEM A 502 ( 3.4A);STR A 501 (-4.5A);HEM A 502 ( 4.0A);STR A 501 (-3.1A)","0.32A","4j6dB-4j6cA:70.2","4j6dB-4j6cA:100.00"],["4JBT_A_ASDA501_1","CYTOCHROME P450 MONOOXYGENASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",12,"MET A  84;PHE A  92;PHE A 179;PHE A 180;GLN A 239;ALA A 240;ALA A 243;ALA A 244;THR A 248;VAL A 291;LEU A 294;GLN A 398","STR A 501 (-4.3A);STR A 501 (-4.0A);STR A 501 (-4.0A);None;STR A 501 ( 4.5A);STR A 501 (-3.6A);STR A 501 ( 3.7A);HEM A 502 (-3.2A);HEM A 502 ( 3.4A);STR A 501 (-4.5A);HEM A 502 ( 4.0A);STR A 501 (-3.1A)","0.26A","4jbtA-4j6cA:70.5","4jbtA-4j6cA:100.00"],["4JBT_B_ASDB502_1","CYTOCHROME P450 MONOOXYGENASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",11,"MET A  84;PHE A  92;PHE A 179;GLN A 239;ALA A 240;ALA A 243;ALA A 244;THR A 248;VAL A 291;LEU A 294;GLN A 398","STR A 501 (-4.3A);STR A 501 (-4.0A);STR A 501 (-4.0A);STR A 501 ( 4.5A);STR A 501 (-3.6A);STR A 501 ( 3.7A);HEM A 502 (-3.2A);HEM A 502 ( 3.4A);STR A 501 (-4.5A);HEM A 502 ( 4.0A);STR A 501 (-3.1A)","0.26A","4jbtB-4j6cA:70.3","4jbtB-4j6cA:100.00"],["4JBT_B_ASDB502_1","CYTOCHROME P450 MONOOXYGENASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",6,"MET A  84;PHE A  92;PHE A 180;ALA A 240;ALA A 243;LEU A 294","STR A 501 (-4.3A);STR A 501 (-4.0A);None;STR A 501 (-3.6A);STR A 501 ( 3.7A);HEM A 502 ( 4.0A)","1.47A","4jbtB-4j6cA:70.3","4jbtB-4j6cA:100.00"],["4WAN_C_ACTC303_0","BRANCHPOINT-BRIDGING PROTEIN","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",3,"ASP A 132;ARG A 156;PRO A 152","None","1.00A","4wanC-4j6cA:undetectable","4wanC-4j6cA:14.15"],["5DX3_A_ESTA601_1","ESTROGEN RECEPTOR","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"LEU A 362;ALA A 363;GLU A 366;GLY A 289;LEU A 285","HEM A 502 ( 4.6A);HEM A 502 (-2.9A);None;None;None","1.31A","5dx3A-4j6cA:2.4","5dx3A-4j6cA:21.52"],["5DXG_B_ESTB601_1","ESTROGEN RECEPTOR","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"LEU A 362;ALA A 363;GLU A 366;GLY A 289;LEU A 285","HEM A 502 ( 4.6A);HEM A 502 (-2.9A);None;None;None","1.26A","5dxgB-4j6cA:undetectable","5dxgB-4j6cA:21.52"],["5GS4_A_ESTA603_2","ESTROGEN RECEPTOR","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",4,"LEU A 153;LEU A 145;LEU A 254;LEU A 371","None","1.02A","5gs4A-4j6cA:2.6","5gs4A-4j6cA:20.43"],["5GTR_A_ESTA601_1","ESTROGEN RECEPTOR","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"LEU A 362;ALA A 363;GLU A 366;GLY A 289;LEU A 285","HEM A 502 ( 4.6A);HEM A 502 (-2.9A);None;None;None","1.07A","5gtrA-4j6cA:undetectable","5gtrA-4j6cA:20.43"],["5GWX_A_SAMA301_1","GLYCINE SARCOSINE N-METHYLTRANSFERASE","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",3,"ARG A 258;ASN A 392;ASP A  18","None","0.80A","5gwxA-4j6cA:undetectable","5gwxA-4j6cA:21.53"],["5HW8_D_FK5D201_1","FK506-BINDING PROTEIN 1","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"VAL A 250;ILE A 253;ILE A 122;ILE A 369;PHE A 149","None","1.16A","5hw8D-4j6cA:undetectable","5hw8D-4j6cA:13.41"],["5K9D_A_ACTA407_0","DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",4,"ASP A 187;GLN A 186;ARG A 189;GLU A 188","None","1.37A","5k9dA-4j6cA:undetectable","5k9dA-4j6cA:22.20"],["5UUN_A_ACTA305_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",3,"THR A  46;MET A 318;HIS A 293","None","1.00A","5uunA-4j6cA:undetectable","5uunA-4j6cA:21.87"],["5X6Y_A_SAMA902_0","MRNA CAPPING ENZYME P5","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",5,"LEU A  26;ALA A 322;GLU A 247;THR A 397;VAL A 395","None;None;None;FMT A 504 (-3.0A);FMT A 504 (-3.8A)","1.20A","5x6yA-4j6cA:undetectable","5x6yA-4j6cA:19.63"],["6A7J_A_TESA502_0","CYTOCHROME P450","4j6c","CYTOCHROME P450 MONOOXYGENASE","Nocardia farcinica",4,"PHE A 179;ALA A 243;ALA A 244;THR A 248","STR A 501 (-4.0A);STR A 501 ( 3.7A);HEM A 502 (-3.2A);HEM A 502 ( 3.4A)","0.26A","6a7jA-4j6cA:58.6","6a7jA-4j6cA:50.00"]]