SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		4 / 6 LEU A 191
ASP A 196
LEU A 269
HIS A 235
 None
 0.76A 1errB-4j6eA:
undetectable		 1errB-4j6eA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		4 / 7 PHE A 115
LEU A  33
VAL A  49
GLY A  50
 None
 0.77A 1p2yA-4j6eA:
undetectable		 1p2yA-4j6eA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		4 / 8 ALA A 264
ALA A 237
ARG A 236
LEU A 212
 None
 0.91A 2bxmA-4j6eA:
undetectable		 2bxmA-4j6eA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		4 / 5 LEU A 191
ASP A 196
LEU A 269
HIS A 235
 None
 0.74A 2jfaA-4j6eA:
undetectable		 2jfaA-4j6eA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		4 / 5 LEU A 191
ASP A 196
LEU A 269
HIS A 235
 None
 0.73A 2qxsA-4j6eA:
undetectable		 2qxsA-4j6eA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		4 / 5 LEU A 191
ASP A 196
LEU A 269
HIS A 235
 None
 0.73A 2qxsB-4j6eA:
undetectable		 2qxsB-4j6eA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		3 / 3 ARG A 236
GLU A 182
ASP A 104
 None
UDG  A 301 (-3.9A)
UDG  A 301 (-3.0A)
 0.93A 3g2oA-4j6eA:
undetectable		 3g2oA-4j6eA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		5 / 10 PHE A 270
VAL A 142
GLY A 268
ILE A 234
GLY A 140
 None
 1.33A 3km6A-4j6eA:
undetectable		 3km6A-4j6eA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		4 / 5 GLN A 169
THR A 187
LEU A 134
LEU A 252
 UDG  A 301 (-3.8A)
UDG  A 301 (-3.8A)
None
None
 1.00A 4lvcB-4j6eA:
undetectable		 4lvcB-4j6eA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		4 / 7 ARG A  62
ILE A  57
PHE A 120
GLU A 114
 None
UDG  A 301 (-3.5A)
None
None
 1.15A 4nosC-4j6eA:
undetectable
4nosD-4j6eA:
undetectable		 4nosC-4j6eA:
21.97
4nosD-4j6eA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		5 / 10 ALA A 213
ALA A 215
ALA A 159
VAL A 211
GLY A 273
 None
 1.04A 4qvyK-4j6eA:
undetectable
4qvyL-4j6eA:
undetectable		 4qvyK-4j6eA:
23.05
4qvyL-4j6eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		5 / 10 ALA A 213
ALA A 215
ALA A 159
VAL A 211
GLY A 273
 None
 1.04A 4qvyY-4j6eA:
undetectable
4qvyZ-4j6eA:
undetectable		 4qvyY-4j6eA:
23.05
4qvyZ-4j6eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		4 / 4 GLN A 169
THR A 187
LEU A 134
LEU A 252
 UDG  A 301 (-3.8A)
UDG  A 301 (-3.8A)
None
None
 1.00A 5m5kB-4j6eA:
undetectable		 5m5kB-4j6eA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		4 / 6 PHE A  58
GLU A 116
ARG A  88
VAL A 111
 None
 1.50A 5unxA-4j6eA:
undetectable
5unxB-4j6eA:
undetectable		 5unxA-4j6eA:
19.81
5unxB-4j6eA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		3 / 3 ARG A 223
PHE A 115
LEU A 108
 None
None
UDG  A 301 (-4.4A)
 0.85A 5x1bC-4j6eA:
undetectable		 5x1bC-4j6eA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI
(Caulobacter
vibrioides) 		5 / 12 ALA A 213
LEU A 156
VAL A 158
VAL A 178
GLY A 176
 None
 1.17A 5x24A-4j6eA:
undetectable		 5x24A-4j6eA:
21.78