SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A  61
VAL A  57
TRP A  74
 None
None
GOL  A 501 (-3.4A)
 0.93A 1c4dC-4j6fA:
undetectable
1c4dD-4j6fA:
undetectable		 1c4dC-4j6fA:
5.29
1c4dD-4j6fA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 4 GLY A  21
LEU A  22
GLY A  20
ARG A  58
 None
 1.25A 1j7kA-4j6fA:
undetectable		 1j7kA-4j6fA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 ASP A 114
ASP A  90
ASP A 312
 GOL  A 500 (-3.6A)
None
None
 0.69A 2igtA-4j6fA:
7.7		 2igtA-4j6fA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 ASP A 114
ASP A  90
ASP A 312
 GOL  A 500 (-3.6A)
None
None
 0.71A 2igtB-4j6fA:
7.3		 2igtB-4j6fA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 7 VAL A 232
ALA A 242
PRO A 211
THR A 186
 None
 0.81A 2q6oA-4j6fA:
undetectable		 2q6oA-4j6fA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 9 PHE A 350
LEU A 203
ILE A 320
GLY A 352
LEU A 328
 None
 1.18A 2v0mB-4j6fA:
undetectable		 2v0mB-4j6fA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 ILE A 325
LEU A 181
ARG A 207
GLY A 208
ALA A 209
 None
 1.22A 2xf3A-4j6fA:
undetectable		 2xf3A-4j6fA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 9 ILE A 325
LEU A 181
ARG A 207
GLY A 208
ALA A 209
 None
 1.21A 2xf3B-4j6fA:
undetectable		 2xf3B-4j6fA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 9 ILE A 325
LEU A 181
ARG A 207
GLY A 208
ALA A 209
 None
 1.19A 2xfsB-4j6fA:
undetectable		 2xfsB-4j6fA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 9 ILE A 325
LEU A 181
ARG A 207
GLY A 208
ALA A 209
 None
 1.23A 2xh9B-4j6fA:
undetectable		 2xh9B-4j6fA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 200
GLY A 191
GLY A 194
ALA A 199
VAL A 259
 None
 0.98A 2yvlB-4j6fA:
9.6		 2yvlB-4j6fA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 200
GLY A 191
GLY A 194
ALA A 199
VAL A 259
 None
 0.93A 2yvlD-4j6fA:
9.1		 2yvlD-4j6fA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 PRO A   8
ILE A  86
VAL A 356
PRO A 358
LEU A 335
 None
 1.21A 3a51B-4j6fA:
undetectable		 3a51B-4j6fA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 195
GLY A 352
LEU A 354
ALA A 168
ASN A  51
 None
 1.16A 3kkzA-4j6fA:
6.7		 3kkzA-4j6fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 132
GLY A 137
LEU A 145
VAL A  57
GLY A 134
 None
 1.04A 3sglA-4j6fA:
3.8		 3sglA-4j6fA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 8 ASP A  90
VAL A 153
PHE A 313
LEU A 316
 None
 1.00A 4f8hA-4j6fA:
undetectable
4f8hB-4j6fA:
undetectable		 4f8hA-4j6fA:
22.43
4f8hB-4j6fA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 8 ASP A  90
VAL A 153
PHE A 313
LEU A 316
 None
 1.06A 4f8hB-4j6fA:
undetectable
4f8hC-4j6fA:
undetectable		 4f8hB-4j6fA:
22.43
4f8hC-4j6fA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 8 ASP A  90
VAL A 153
PHE A 313
LEU A 316
 None
 1.01A 4f8hC-4j6fA:
undetectable
4f8hD-4j6fA:
undetectable		 4f8hC-4j6fA:
22.43
4f8hD-4j6fA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 8 ASP A  90
VAL A 153
PHE A 313
LEU A 316
 None
 1.01A 4f8hD-4j6fA:
undetectable
4f8hE-4j6fA:
undetectable		 4f8hD-4j6fA:
22.43
4f8hE-4j6fA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 8 VAL A 153
PHE A 313
LEU A 316
ASP A  90
 None
 1.02A 4f8hA-4j6fA:
undetectable
4f8hE-4j6fA:
undetectable		 4f8hA-4j6fA:
22.43
4f8hE-4j6fA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 ARG A 310
ASP A  90
GLY A 137
PRO A 146
 GOL  A 500 (-4.6A)
None
None
None
 0.85A 4l1aB-4j6fA:
undetectable		 4l1aB-4j6fA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A 113
THR A  53
ASP A  54
VAL A  55
TYR A 139
 None
GOL  A 501 ( 4.0A)
None
None
None
 1.47A 6h7lA-4j6fA:
undetectable		 6h7lA-4j6fA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A 113
THR A  53
ASP A  54
VAL A  55
TYR A 139
 None
GOL  A 501 ( 4.0A)
None
None
None
 1.45A 6h7lB-4j6fA:
undetectable		 6h7lB-4j6fA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4j6f PUTATIVE ALCOHOL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 7 ARG A 315
TYR A 319
GLU A 173
ASP A 312
 None
 1.16A 6mn5B-4j6fA:
3.1		 6mn5B-4j6fA:
12.57