SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j73'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4j73 COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 136
GLY A 171
SER A 154
THR A 155
 None
 1.26A 1icuC-4j73A:
undetectable
1icuD-4j73A:
undetectable		 1icuC-4j73A:
20.92
1icuD-4j73A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4j73 COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 136
GLY A 171
SER A 154
THR A 155
 None
 1.18A 1icvA-4j73A:
undetectable
1icvB-4j73A:
undetectable		 1icvA-4j73A:
20.92
1icvB-4j73A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 4j73 COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  71
TRP A 124
LEU A 123
TRP A 130
 None
 1.34A 1q0yH-4j73A:
undetectable
1q0yL-4j73A:
undetectable		 1q0yH-4j73A:
20.26
1q0yL-4j73A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4j73 COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 115
ILE A 100
TRP A 124
VAL A 112
 None
 1.19A 1rs7A-4j73A:
undetectable		 1rs7A-4j73A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 4j73 COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		5 / 9 VAL A  58
GLY A  18
ILE A  19
ILE A  39
ILE A  70
 None
 0.80A 3s43A-4j73A:
undetectable		 3s43A-4j73A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4j73 COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 269
ARG A  12
SER A 245
VAL A 231
HIS A 227
 None
 1.44A 4ffwA-4j73A:
5.0		 4ffwA-4j73A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4j73 COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 183
THR A 209
ASP A 207
 None
 0.70A 5k9dA-4j73A:
undetectable		 5k9dA-4j73A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4j73 COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 159
SER A 205
THR A 203
VAL A 165
 None
 1.18A 5ysiA-4j73A:
undetectable		 5ysiA-4j73A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4j73 COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 292
ASN A 267
LEU A 252
PHE A 233
 None
 0.99A 6ekuA-4j73A:
5.6		 6ekuA-4j73A:
19.48